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公开(公告)号：US20100041683A1
公开(公告)日：2010-02-18
申请号：US12485799
申请日：2009-06-16
申请人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
发明人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
IPC分类号： A61K31/505 , C07D239/02 , A61P43/00
CPC分类号： C07D213/73 , C07D213/74 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/52 , C07D471/04 , C07F9/58 , C07F9/6512 , C07F9/6561 , C09K15/30
摘要： Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.
摘要翻译： 化合物，优选5-嘧啶醇和3-吡啶醇衍生物，其作为脂质和水溶性品种（类似于天然维生素E和C）的有效链断裂抗氧化剂，其中许多对过氧自由基反应性高于 维生素E最有效的形式。这些化合物可能表现出与自由基介导的细胞损伤或破坏牵连的情况相关的许多化学预防作用，维生素E和C显示具有保护作用。 此外，这些化合物应是优异的氧化抑制剂，作为燃料，润滑剂，橡胶，聚合物，化学品，溶剂和食品的添加剂。
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公开(公告)号：US07547709B2
公开(公告)日：2009-06-16
申请号：US10980664
申请日：2004-11-02
申请人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
发明人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
IPC分类号： A61K31/44 , C07D471/02 , C07D515/02 , C07D211/68
CPC分类号： C07D213/73 , C07D213/74 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/52 , C07D471/04 , C07F9/58 , C07F9/6512 , C07F9/6561 , C09K15/30
摘要： Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.
摘要翻译： 化合物，优选5-嘧啶醇和3-吡啶醇衍生物，其作为脂质和水溶性品种（类似于天然维生素E和C）的有效链断裂抗氧化剂，其中许多对过氧自由基反应性高于 维生素E最有效的形式。这些化合物可能表现出与自由基介导的细胞损伤或破坏牵连的情况相关的许多化学预防作用，维生素E和C显示具有保护作用。 此外，这些化合物应是优异的氧化抑制剂，作为燃料，润滑剂，橡胶，聚合物，化学品，溶剂和食品的添加剂。
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公开(公告)号：US06835216B2
公开(公告)日：2004-12-28
申请号：US09891671
申请日：2001-06-26
申请人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
发明人： Derek A. Pratt , Luca Valgimigli , Gino A. DiLabio
IPC分类号： C07D23947
CPC分类号： C07D213/73 , C07D213/74 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/52 , C07D471/04 , C07F9/58 , C07F9/6512 , C07F9/6561 , C09K15/30
摘要： Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.
摘要翻译： 化合物，优选5-嘧啶醇和3-吡啶醇衍生物，其作为脂质和水溶性品种（类似于天然维生素E和C）的有效链断裂抗氧化剂，其中许多对过氧自由基反应性高于 维生素E最有效的形式。这些化合物可能表现出与自由基介导的细胞损伤或破坏牵连的情况相关的许多化学预防作用，维生素E和C显示具有保护作用。 此外，这些化合物应是优异的氧化抑制剂，作为燃料，润滑剂，橡胶，聚合物，化学品，溶剂和食品的添加剂。
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公开(公告)号：US09738606B2
公开(公告)日：2017-08-22
申请号：US14123452
申请日：2012-06-04
IPC分类号： C07D213/74 , C07D239/48 , C07D401/12 , C07C7/20 , C07C67/62 , C08K5/3462 , C08K5/3432 , C09K15/30 , C07D239/42 , C07D239/47 , C10M169/04
CPC分类号： C07D213/74 , C07C7/20 , C07C67/62 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/12 , C08K5/3432 , C08K5/3462 , C09K15/30 , C10M169/04
摘要： A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants.In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.
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公开(公告)号：US20140206585A1
公开(公告)日：2014-07-24
申请号：US14123452
申请日：2012-06-04
IPC分类号： C07D213/74 , C07D239/48 , C07D401/12 , C07D239/47 , C07C67/62 , C10M169/04 , C08K5/3432 , C07D239/42 , C07C7/20
CPC分类号： C07D213/74 , C07C7/20 , C07C67/62 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/12 , C08K5/3432 , C08K5/3462 , C09K15/30 , C10M169/04
摘要： A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants.In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.
摘要翻译： 式I，式IA，式IB或式II的化合物或其酸或碱加成盐，以及这些化合物作为抗氧化剂的用途。 在一个实施方案中，式II化合物，其中X，Y和Z各自独立地为碳或氮原子; R 1和R 2各自独立地为氢或给电子基团，但不同时为氢，并且其中R 1和R 2各自与其各自的芳环中的碳原子键合。
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