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1.发明申请Compositions Comprising Cationic Microparticles And Hcv B1e2 Dna And Methods Of Use Thereof 审中-公开包含阳离子微粒和Hcv B1e2 Dna的组合物及其使用方法公开(公告)号：US20070264285A1
公开(公告)日：2007-11-15
申请号：US10554625
申请日：2004-04-23
申请人： Derek O'Hagan , Michael Houghton , Manmohan Singh
发明人： Derek O'Hagan , Michael Houghton , Manmohan Singh
CPC分类号： A61K31/7088 , A61K9/0019 , A61K9/1617 , A61K9/1647 , A61K39/12 , A61K39/29 , A61K39/39 , A61K47/6927 , A61K48/00 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要： Immunogenic HCV E1E2809 DNA compositions and methods of using the same are described. The compositions comprise HCV EIE2809 DNA adsorbed to cationic microparticles, such as poly(lactide-co-glycolide) (PLG) microparticles.
摘要翻译： 描述了免疫原性HCV E1E2 809 DNA组合物及其使用方法。 组合物包含吸附在阳离子微粒（如聚（丙交酯 - 共 - 乙交酯）（PLG））微粒上的HCV EIE2 809NN。
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公开(公告)号：US20110159039A1
公开(公告)日：2011-06-30
申请号：US12871035
申请日：2010-08-30
CPC分类号： C07K14/005 , A61K9/167 , A61K31/7088 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.
摘要翻译： 本文描述的是使用HCV E2或HCV E1E2多肽和/或HCV E2或E1E2多核苷酸引发抗体并中和针对丙型肝炎病毒（HCV）E1E2或E2抗原的结合抗体的方法。 可以使用抗E2抗体和抗E2 NOB抗体的引发，以提供模型系统来优化抗E2抗体应答和/或抗HCV NOB抗体对HCV的反应，并提供针对HCV的预防或治疗性治疗 感染。
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公开(公告)号：US20080095800A1
公开(公告)日：2008-04-24
申请号：US12001920
申请日：2007-12-13
CPC分类号： C07K14/005 , A61K9/167 , A61K31/7088 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.
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公开(公告)号：US07329408B2
公开(公告)日：2008-02-12
申请号：US09728423
申请日：2000-12-01
IPC分类号： A61K39/29
CPC分类号： C07K14/005 , A61K9/167 , A61K31/7088 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.
摘要翻译： 本文描述的是使用HCV E2或HCV E1E2多肽和/或HCV E2或E1E2多核苷酸引发抗体并中和针对丙型肝炎病毒（HCV）E1E2或E2抗原的结合抗体的方法。 可以使用抗E2抗体和抗E2 NOB抗体的引发，以提供模型系统来优化抗E2抗体应答和/或抗HCV NOB抗体对HCV的反应，并提供针对HCV的预防或治疗性治疗 感染。
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公开(公告)号：US20120141529A1
公开(公告)日：2012-06-07
申请号：US13355192
申请日：2012-01-20
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US08142793B2
公开(公告)日：2012-03-27
申请号：US12383425
申请日：2009-03-24
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US20110014652A1
公开(公告)日：2011-01-20
申请号：US12383419
申请日：2009-03-24
IPC分类号： C12P21/02
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US20100291129A1
公开(公告)日：2010-11-18
申请号：US12383420
申请日：2009-03-24
IPC分类号： A61K39/125 , A61K39/295 , A61P31/14 , A61P31/00 , A61K39/12
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US20100262178A1
公开(公告)日：2010-10-14
申请号：US12824343
申请日：2010-06-28
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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公开(公告)号：US07785290B2
公开(公告)日：2010-08-31
申请号：US11501190
申请日：2006-08-07
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译： 本发明提供一种实现直径大于6mm的气囊，用于固定到导管。 气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。
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