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    G-protein coupled receptor HUVCT36
    1.
    发明授权
    G-protein coupled receptor HUVCT36 失效
    G蛋白偶联受体HUVCT36

    公开(公告)号：US5912335A

    公开(公告)日：1999-06-15

    申请号：US724974

    申请日：1996-10-03

    申请人： Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/26 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07K14/705 ,  C12N5/00 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Human HUVCT36 polypeptides and DNA (RNA) encoding such HUVCT36 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HUVCT36 for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HUVCT36 and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人HUVCT36多肽和编码这种HUVCT36的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种HUVCT36来治疗感染的方法，例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 过敏 良性前列腺肥大; 还公开了精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett's等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HUVCT36的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Human 7-transmembrane receptor and DNA
    2.
    发明授权
    Human 7-transmembrane receptor and DNA 失效
    人类7-跨膜受体和DNA

    公开(公告)号：US5824504A

    公开(公告)日：1998-10-20

    申请号：US742011

    申请日：1996-10-31

    申请人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/7158 ,  A61K38/00

    摘要： Human HBMBU14 polypeptides and DNA (RNA) encoding such HBMBU14 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HBMBU14 for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 and HIV-2, pain, cancers, anorexia, bulimia, asthma, Parkinson's disease, acute heart failure, atherosclerosis, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourette's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HBMBU14 and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人HBMBU14多肽和编码这种HBMBU14的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HBMBU14来治疗感染例如细菌，真菌，原生动物和病毒感染的方法，特别是HIV-1和HIV-2引起的感染，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病，急性 心力衰竭，动脉粥样硬化，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗塞，溃疡，哮喘，过敏，良性前列腺肥大和精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝 ，以及运动障碍，如亨廷顿病或吉列斯·杜拉图雷特综合征等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HBMBU14的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Isolated nucleic acid encoding G-protein coupled receptor (HTADX50)
    3.
    发明授权
    Isolated nucleic acid encoding G-protein coupled receptor (HTADX50) 失效
    分离的编码G蛋白偶联受体的核酸（HTADX50）

    公开(公告)号：US5910430A

    公开(公告)日：1999-06-08

    申请号：US788750

    申请日：1997-01-24

    申请人： Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/08 ,  C07K14/705 ,  C12N5/00 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/62

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HTADX50 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTADX50 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HTADX50多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HTADX50多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
    6.
    发明授权
    cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor 失效
    编码新型人7-跨膜受体的cDNA克隆HMTMF81

    公开(公告)号：US06200775B1

    公开(公告)日：2001-03-13

    申请号：US09044404

    申请日：1998-03-19

    申请人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    发明人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    IPC分类号： C12N1512

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HMTMF81 polypeptides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris, myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HMTMF81多肽和通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HMTMF81多肽和多核苷酸的方法; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛，心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    HMTF81 human 7-transmembrane receptor
    7.
    发明授权
    HMTF81 human 7-transmembrane receptor 失效
    HMTF81人7-跨膜受体

    公开(公告)号：US06506878B1

    公开(公告)日：2003-01-14

    申请号：US09586924

    申请日：2000-06-05

    申请人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    发明人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    IPC分类号： C07K14705

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HMTMF81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HMTMF81多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HMTMF81多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    11 cby genomic sequence
    8.
    发明授权
    11 cby genomic sequence 失效
    11 cby基因组序列

    公开(公告)号：US06362326B1

    公开(公告)日：2002-03-26

    申请号：US09218467

    申请日：1998-12-22

    申请人： Ganesh Sathe ,  Catherine E. Ellis ,  Wendy Halsey ,  Derk Bergsma

    发明人： Ganesh Sathe ,  Catherine E. Ellis ,  Wendy Halsey ,  Derk Bergsma

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K48/00

    摘要： The present invention relates to 11cby, in particular 11cby polypeptides and 11cby polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, hereinafter referred to as “the Diseases”, among others. In a still further aspect, the invention relates to diagnostic and prognostic assays for detecting diseases associated with inappropriate 11cby activity or levels. A method of performing genetic association studies for searching a disease susceptibility and/or drug response genes comprising using polymorphic markers in 11cby polynucleotides.

    摘要翻译： 本发明涉及11cby，特别是11cby多肽和11cby多核苷酸，重组材料及其生产方法。 另一方面，本发明涉及使用这些多肽和多核苷酸的方法，包括治疗细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染; 疼痛; 癌症; 糖尿病; 肥胖; 饮食异常，如厌食和贪食; 哮喘; 帕金森病 急性和充血性心力衰竭; 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 过敏 良性前列腺肥大和精神病性和神经系统疾病，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝，以及运动障碍，如亨廷顿舞蹈病或Gilles dela Tourett综合征，以下简称“疾病”等。 在另一方面，本发明涉及用于检测与不适当的11cby活性或水平相关的疾病的诊断和预后测定。 用于搜索疾病易感性和/或药物应答基因的遗传关联研究的方法包括在11cby多核苷酸中使用多态性标记。