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公开(公告)号：US20190083018A1
公开(公告)日：2019-03-21
申请号：US16185957
申请日：2018-11-09
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/1486 , B05D5/00 , B05D3/00 , A61B5/1473 , A61B5/145 , C12Q1/00 , B01D71/80 , B01D71/54 , B01D69/14 , A61L31/12
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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2.发明授权公开(公告)号：US09179869B2
公开(公告)日：2015-11-10
申请号：US14482458
申请日：2014-09-10
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61F5/44 , B05D3/00 , C12Q1/54 , G01N27/28 , A61B5/1473 , A61B5/1486 , C12Q1/00 , A61L31/12 , B01D69/14 , B01D71/54 , B01D71/80 , A61B5/145 , B05D5/00
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
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公开(公告)号：US09801574B2
公开(公告)日：2017-10-31
申请号：US14875539
申请日：2015-10-05
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/05 , A61B5/1486 , C12Q1/00 , A61L31/12 , B01D69/14 , B01D71/54 , B01D71/80 , A61B5/145 , A61B5/1473 , B05D3/00 , B05D5/00
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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4.发明授权公开(公告)号：US08865249B2
公开(公告)日：2014-10-21
申请号：US13631780
申请日：2012-09-28
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
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Patent Agency Ranking
公开(公告)号：US10154807B2
公开(公告)日：2018-12-18
申请号：US15716998
申请日：2017-09-27
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/05 , A61B5/1486 , C12Q1/00 , A61L31/12 , B01D69/14 , B01D71/54 , B01D71/80 , A61B5/145 , A61B5/1473 , B05D3/00 , B05D5/00
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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公开(公告)号：US20180014765A1
公开(公告)日：2018-01-18
申请号：US15716998
申请日：2017-09-27
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/1486 , B05D5/00 , B05D3/00 , A61L31/12 , B01D71/54 , B01D69/14 , A61B5/145 , A61B5/1473 , C12Q1/00 , B01D71/80
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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7.发明申请公开(公告)号：US20140378798A1
公开(公告)日：2014-12-25
申请号：US14482458
申请日：2014-09-10
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/1473 , B05D5/00 , B05D3/00 , A61B5/145
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
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公开(公告)号：US20160022186A1
公开(公告)日：2016-01-28
申请号：US14875539
申请日：2015-10-05
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/1486 , A61B5/145
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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9.发明申请公开(公告)号：US20130030273A1
公开(公告)日：2013-01-31
申请号：US13631780
申请日：2012-09-28
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
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