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公开(公告)号:US4988730A
公开(公告)日:1991-01-29
申请号:US385539
申请日:1989-07-21
申请人: Dezso Korbonits , Pal Kiss , Laszlo Szekeres , Gyula Papp , Gabor Kovacs , Andrea Santane Csutor , Sandor Virag , Eva Udvari , Imre Bata , Katalin Marmarosi nee Kellner , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Zoltan Vargai
发明人: Dezso Korbonits , Pal Kiss , Laszlo Szekeres , Gyula Papp , Gabor Kovacs , Andrea Santane Csutor , Sandor Virag , Eva Udvari , Imre Bata , Katalin Marmarosi nee Kellner , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Zoltan Vargai
IPC分类号: C07C215/50 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/335 , A61K31/36 , A61P3/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07C20060101 , C07C27/00 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/24 , C07C209/26 , C07C209/62 , C07C209/68 , C07C211/00 , C07C211/03 , C07C211/16 , C07C211/26 , C07C211/27 , C07C211/29 , C07C211/43 , C07C213/00 , C07C217/10 , C07C217/54 , C07C217/56 , C07C217/58 , C07C227/10 , C07C227/16 , C07C229/34 , C07C229/38 , C07C231/00 , C07C231/12 , C07C233/42 , C07C233/43 , C07C233/67 , C07D311/48 , C07D317/00 , C07D317/48 , C07D317/58
CPC分类号: C07D317/58 , C07C211/27 , C07C211/29 , C07C217/58 , C07C233/43
摘要: The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group;Z means a phenyl group substituted by R.sup.3, R.sup.4 and R.sup.5, whereinR.sup.3 means hydrogen, fluorine, chlorine or bromine, or a nitro, C.sub.1-12 alkyl, C.sub.1-4 alkoxy, phenoxy or benzyloxy group;R.sup.4 and R.sup.5 represent hydrogen, chlorine or a hydroxy, alkoxy, benzyloxy, acetamino or carboxy group; orR.sup.4 and R.sup.5 together form a methylendioxy group; orZ may stand for a 4-methoxynaphtyl or 4-ethoxy-naphthyl group; andR.sup.6 stands for hydrogen or fluorine, with the proviso that each of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 cannot simultaneously stand for hydrogen, as well as their physiologically acceptable acid addition salts.The invention also relates to a process for the preparation of these compounds and to the pharmaceutical compositions containing these compounds.The compounds of the general formula (I) can preferably be used for the treatment of cardiovascular diseases.
摘要翻译: 本发明涉及通式(I)的新型二苯基丙胺衍生物。 (I)R1代表氢或甲基; R2代表氢,甲基或正癸基; Z表示被R 3,R 4和R 5取代的苯基,其中R 3表示氢,氟,氯或溴,或硝基,C 1-12烷基,C 1-4烷氧基,苯氧基或苄氧基; R4和R5代表氢,氯或羟基,烷氧基,苄氧基,乙酰氨基或羧基; 或R4和R5一起形成甲基二氧基; 或Z可以代表4-甲氧基萘基或4-乙氧基 - 萘基; 并且R6代表氢或氟,条件是R1,R2,R3,R4和R6各自不能同时代表氢,以及它们的生理上可接受的酸加成盐。 本发明还涉及制备这些化合物的方法和含有这些化合物的药物组合物。 通式(I)的化合物可优选用于治疗心血管疾病。
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2.
公开(公告)号:US4840949A
公开(公告)日:1989-06-20
申请号:US107693
申请日:1987-10-09
申请人: Dezso Korbonits , Emil Minker , Zoltan Vargai , Gergely Heja , Gabor Kovacs , Agnes Gottsegen , Sandor Antus , Sandor Virag , Andrea Bolehovszky , Jeno Marton , Katalin Marmarosi nee Kellner , Lorand Debreczeni , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Gabor Horvath
发明人: Dezso Korbonits , Emil Minker , Zoltan Vargai , Gergely Heja , Gabor Kovacs , Agnes Gottsegen , Sandor Antus , Sandor Virag , Andrea Bolehovszky , Jeno Marton , Katalin Marmarosi nee Kellner , Lorand Debreczeni , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Gabor Horvath
IPC分类号: C07D473/04 , A61K31/52 , A61K31/522 , A61P11/04 , A61P11/14 , C07D271/06 , C07D273/02 , C07D473/06
CPC分类号: C07D473/06
摘要: The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene andR.sup.1 represents C.sub.1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C.sub.5-6 cycloalkyl or aminoalkyl of the Formula --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 in which group n is an integer 1-3; R.sup.2 and R.sup.3 each stand for hydrogen or C.sub.1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; orR.sup.1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzylThe compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.
摘要翻译: 本发明涉及式I的新型氧化噻唑烷基嘌呤衍生物及其药学上可接受的盐,其中A代表C1-4亚烷基,R1代表C1-6烷基,羟基烷基,卤代烷基,羧基烷基,C5-6环烷基 或其中基团n为整数1-3的式 - (CH 2)n -NR 2 R 3的氨基烷基; R 2和R 3各自代表氢或C 1-4烷基或与它们相连的相邻氮原子一起形成5-或6-元含氮杂环,其可以任选地包含另外的氮原子或氧原子作为杂原子; 或R 1代表苯基,羟基苯基,羧基苯基,苄基或二甲氧基苄基。式I化合物可以通过本身已知的方法制备,并且可用于作为止咳剂的治疗。
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