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    Disodium pamidronate formulation
    1.
    发明申请
    Disodium pamidronate formulation 审中-公开
    帕米膦酸二钠制剂

    公开(公告)号：US20060217350A1

    公开(公告)日：2006-09-28

    申请号：US11245389

    申请日：2005-10-06

    申请人： Dhiraj Khattar ,  Manish Grover ,  Mukesh Kumar ,  Prasanna Kumar Srinivasa Jonnala ,  Shobhit Singh ,  Rama Mukherjee ,  Anand Burman

    发明人： Dhiraj Khattar ,  Manish Grover ,  Mukesh Kumar ,  Prasanna Kumar Srinivasa Jonnala ,  Shobhit Singh ,  Rama Mukherjee ,  Anand Burman

    IPC分类号： A61K31/66

    CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/663 ,  A61K47/26

    摘要： A stable pharmaceutical composition comprising a solution of disodium pamidronate in an aqueous solvent and a process for the preparation thereof. The solution of disodium pamidronate is free of particulate matter and has an alkaline pH. The process for preparation of the stable pharmaceutical composition comprises adding disodium pamidronate and optionally a sugar into an aqueous solvent; heating the said mixture at a temperature in the range of 50° C. to 90° C. to obtain a clear solution. It is cooled to ambient temperature, filtered, filled and stored in a conventional and untreated glass container and sealed with normal elastomeric closure. The sealed container is sterilized by steam sterilization.

    摘要翻译： 一种稳定的药物组合物，其包含在水性溶剂中的帕米膦酸二钠溶液及其制备方法。 帕米膦酸二钠的溶液不含颗粒物质，具有碱性pH。 制备稳定的药物组合物的方法包括将帕米膦酸二钠和任选的糖加入到含水溶剂中; 在50℃至90℃的温度下加热所述混合物以获得澄清溶液。 将其冷却至环境温度，过滤，填充并储存在常规和未处理的玻璃容器中并用正常弹性封闭物密封。 密封容器通过蒸汽灭菌灭菌。

    Stable pharmaceutical compositions of platinum (II) antitumour agents
    7.
    发明申请
    Stable pharmaceutical compositions of platinum (II) antitumour agents 审中-公开
    稳定的铂（II）抗肿瘤药物组合物

    公开(公告)号：US20060216360A1

    公开(公告)日：2006-09-28

    申请号：US11245141

    申请日：2005-10-06

    申请人： Satish Upadhyay ,  Manoj Pananchukunnath ,  Dinesh Kumar ,  Ajeet Singh ,  Rama Mukherjee ,  Anand Burman

    发明人： Satish Upadhyay ,  Manoj Pananchukunnath ,  Dinesh Kumar ,  Ajeet Singh ,  Rama Mukherjee ,  Anand Burman

    IPC分类号： A61K33/24 ,  A61K31/282

    CPC分类号： A61K33/24 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/282 ,  A61K31/555

    摘要： A pharmaceutical composition comprising a platinum (II) complex compound in n aqueous solvent. The pharmaceutical composition is prepared by the essential steps of: (i) adding a platinum (II) complex compound to an oxygen enriched aqueous solvent to obtain a solution; (ii) Sterilizing the solution (iii) Filling the sterilizedsolution of step (ii) into suitable containers; and (iv) Sealing the containers. The oxygen enriched aqueous solvent is obtained by purging or bubbling of a gas into an aqueous solvent for 30 to 150 minutes. A device for preparing the pharmaceutical composition is illustrated in FIG. 1. The composition is used for treatment of a human or an animal cancerous disease by the administration of pharmaceutical compositions of platinum (II) complex compounds as per the claim 1, to the human or animal in need of said treatment.

    摘要翻译： 一种包含在n水溶液中的铂（II）络合物化合物的药物组合物。 药物组合物通过以下步骤制备：（i）向富氧水溶剂中加入铂（II）络合物，得到溶液; （ii）灭菌溶液（iii）将步骤（ii）的无菌溶液装入合适的容器中; 和（iv）密封容器。 通过将气体吹扫或鼓泡到含水溶剂中30至150分钟来获得富氧水溶剂。 用于制备药物组合物的装置在图1中示出。 1.通过将权利要求1的铂（II）配合物化合物的药物组合物给予需要所述治疗的人或动物，该组合物用于治疗人或动物癌性疾病。