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公开(公告)号：US20170037442A1
公开(公告)日：2017-02-09
申请号：US14876413
申请日：2015-10-06
Applicant: Dick Fitzgerald , Dara O'Sullivan
Inventor： Dick Fitzgerald , Dara O'Sullivan
CPC classification number: C12P21/06 , A23J3/344 , A23L33/18 , A23L33/40 , A23V2002/00 , C07K14/4732 , A23V2200/03 , A23V2200/304 , A23V2250/54246 , A23V2300/28
Abstract: A casein hydrolysate formed by controlled hydrolysis of a casein substrate by an aspergillus-derived (fugal) proteolytic preparation is described. The controlled hydrolysis employs a FlavorPro-Whey™ formulation and a degree of hydrolysis (% DH) of from 5% DH to 15% DH. The Hydrolysate has at least a 98% reduction in antigenicity compared to intact sodium caseinate and a mean bitterness score of less than 30%. The invention also provides a low molecular weight fraction of casein hydrolysate of the invention which is substantially free of peptides having a molecular weight greater than 5 kDa.
Abstract translation: 描述了通过曲霉衍生（矮化）蛋白水解制剂对酪蛋白底物的可控水解形成的酪蛋白水解产物。 受控的水解使用FlavorPro-Whey TM制剂和5％DH至15％DH的水解度（％DH）。 与完整的酪蛋白酸钠相比，水解产物的抗原性降低至少98％，平均苦味评分低于30％。 本发明还提供本发明的酪蛋白水解产物的低分子量级分，其基本上不含分子量大于5kDa的肽。
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公开(公告)号：US20140213762A1
公开(公告)日：2014-07-31
申请号：US13985321
申请日：2012-02-17
Applicant: Dick Fitzgerald , Dara O'Sullivan
Inventor： Dick Fitzgerald , Dara O'Sullivan
IPC: C07K14/47
CPC classification number: C12P21/06 , A23J3/344 , A23L33/18 , A23L33/40 , A23V2002/00 , C07K14/4732 , A23V2200/03 , A23V2200/304 , A23V2250/54246 , A23V2300/28
Abstract: A casein hydrolysate formed by controlled hydrolysis of a casein substrate by an aspergillus-derived (fugal) proteolytic preparation is described. The controlled hydrolysis employs a FlavorPro-Whey™ formulation and a degree of hydrolysis (% DH) of from 5% DH to 15% DH. The hydrolysate has at least a 98% reduction in antigenicity compared to intact sodium caseinate and a mean bitterness score of less than 30%. The invention also provides a low molecular weight fraction of a casein hydrolysate of the invention which is substantially free of peptides having a molecular weight greater than 5 kDa
Abstract translation: 描述了通过曲霉衍生（矮化）蛋白水解制剂对酪蛋白底物的可控水解形成的酪蛋白水解产物。 受控的水解使用FlavorPro-Whey TM制剂和5％DH至15％DH的水解度（％DH）。 与完整的酪蛋白酸钠相比，水解产物的抗原性降低至少98％，平均苦味评分小于30％。 本发明还提供了本发明的酪蛋白水解产物的低分子量级分，其基本上不含分子量大于5kDa的肽
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公开(公告)号：US20100305050A1
公开(公告)日：2010-12-02
申请号：US12792133
申请日：2010-06-02
Applicant: Dick Fitzgerald , Ebenezer Rajarathnam , Dara O'Sullivan
Inventor： Dick Fitzgerald , Ebenezer Rajarathnam , Dara O'Sullivan
CPC classification number: C08L89/005 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K8/64 , A61K35/20 , A61Q19/00 , A23V2250/54246 , A23V2200/304
Abstract: A bovine casein protein hydrolysate prepared using an enzyme having broad spectrum endopeptidase activity has low residual antigenicity properties in mammals compared to intact casein protein, The composition is useful as an ingredient in foods, beverages, pharmaceutical and cosmetic products. A hydrolysate prepared using Alcalase™ with a degree of hydrolysis of 19.88% has very desirably low antigenicity characteristics.
Abstract translation: 使用具有广谱肽链内切酶活性的酶制备的牛酪蛋白水解产物与完整酪蛋白相比在哺乳动物中具有较低的残留抗原性。该组合物可用作食品，饮料，药物和化妆品中的成分。 使用水解度为19.88％的Alcalase TM制备的水解产物具有非常理想的低抗原性特征。
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公开(公告)号：US20110130637A1
公开(公告)日：2011-06-02
申请号：US12933533
申请日：2009-03-19
Applicant: Dick Fitzgerald , Allan Struthers
Inventor： Dick Fitzgerald , Allan Struthers
CPC classification number: A61K38/018
Abstract: A composition for use in the treatment or prophylaxis of conditions mediated by endothelial function in mammals is provided. The composition includes a milk protein hydrolysate generated by treating milk or milk whey protein with a proteolytic enzyme having subtilisin or subtilisin-like activity and/or glutamyl endopeptidase or glutamyl endopeptidase-like activity. The composition is useful in the management of vascular conditions.
Abstract translation: 提供了用于治疗或预防哺乳动物内皮功能介导的病症的组合物。 该组合物包括通过用具有枯草杆菌蛋白酶或枯草杆菌蛋白酶样活性的蛋白水解酶和/或谷氨酰内肽酶或谷氨酰肽内肽酶活性来处理乳或乳清蛋白产生的乳蛋白水解产物。 该组合物可用于管理血管病症。
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