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    Process for the synthesis of highly pure cationic surfactant products
    2.
    发明授权
    Process for the synthesis of highly pure cationic surfactant products 有权

    公开(公告)号：US10287242B2

    公开(公告)日：2019-05-14

    申请号：US14369410

    申请日：2012-05-04

    申请人： Dilip S. Mehta ,  Mayank Shastri

    发明人： Dilip S. Mehta ,  Mayank Shastri

    IPC分类号： C07C229/00 ,  C07C277/08

    摘要： The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

    PROCESS FOR THE SYNTHESIS OF HIGHLY PURE CATIONIC SURFACTANT PRODUCTS
    4.
    发明申请
    PROCESS FOR THE SYNTHESIS OF HIGHLY PURE CATIONIC SURFACTANT PRODUCTS 审中-公开
    合成高纯度阳离子表面活性剂产品的方法

    公开(公告)号：US20140323756A1

    公开(公告)日：2014-10-30

    申请号：US14369410

    申请日：2012-05-04

    申请人： Dilip S. Mehta ,  Mayank Shastri

    发明人： Dilip S. Mehta ,  Mayank Shastri

    IPC分类号： C07C277/08

    CPC分类号： C07C277/08 ,  C07C279/14

    摘要： The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

    摘要翻译： 本发明涉及通过消除或减少现有技术中杂质产生来合成高纯度阳离子表面活性剂产品。 这是通过氨基酸及其无机盐或其有机盐（例如氨基酸或氨基酸的硫酸盐或氨基酸的乙酸盐的氨基酸或盐酸盐）的N-酰化在非水解或几乎不 水解反应条件涉及单或双相反应体系与脂肪酰卤（C4至C20），在中等均匀碱性条件下，产生高纯度N-酰基取代的氨基酸酯，特别是精氨酸月桂酸乙酯。 本方法通过过程策略而不是测量和控制步骤实现pH控制。 这种环境温度过程通过一系列温度变化而稳定，消除了刚性低温控制。

    Process for improved recovery of fermentation products from intracellular and extracellular presence
    5.
    发明申请
    Process for improved recovery of fermentation products from intracellular and extracellular presence 审中-公开
    从细胞内和细胞外存在改善发酵产物的回收方法

    公开(公告)号：US20110201054A1

    公开(公告)日：2011-08-18

    申请号：US12661547

    申请日：2010-03-18

    申请人： Dilip S. Mehta ,  Anselm de Souza

    发明人： Dilip S. Mehta ,  Anselm de Souza

    IPC分类号： C12P7/26 ,  C12N9/00 ,  C12P19/42 ,  C12P7/62 ,  C12P17/06

    CPC分类号： C12P7/66 ,  B01D1/18 ,  C12P17/06 ,  C12P19/42 ,  C12P21/02

    摘要： The present invention increases yield of the target fermented molecules by spray drying the fermentation broth and reducing the process volume to nearly one tenth the original. Thus, none of the target molecules are lost and requirements of the solvent and the other conventional method process equipments and processing materials are reduced considerably. Product recovery is improved. A major saving in the waste water treatment offsets spray drying and offers better process economics.

    摘要翻译： 本发明通过喷雾干燥发酵液并将处理量减少到原来的十分之一来提高目标发酵分子的产量。 因此，没有一个目标分子丢失，溶剂和其他常规方法的处理设备和加工材料的要求大大降低。 产品回收率提高。 主要节省废水处理抵消了喷雾干燥，并提供了更好的工艺经济性。

    TREATMENT OF HUMAN DISEASE CONDITIONS AND DISORDERS USING VITAMIN K ANALOGUES AND DERIVATIVES
    6.
    发明申请
    TREATMENT OF HUMAN DISEASE CONDITIONS AND DISORDERS USING VITAMIN K ANALOGUES AND DERIVATIVES 审中-公开
    使用维生素K类似物和衍生物治疗人类疾病状况和疾病

    公开(公告)号：US20100130618A1

    公开(公告)日：2010-05-27

    申请号：US12452803

    申请日：2008-07-21

    申请人： Ashok B Vaidya ,  Dilip S. Mehta ,  Anselm de Souza ,  Rama A. Vaidya

    发明人： Ashok B Vaidya ,  Dilip S. Mehta ,  Anselm de Souza ,  Rama A. Vaidya

    IPC分类号： A61K31/122 ,  A61P17/00

    CPC分类号： A61K31/122

    摘要： The present invention is related to the therapeutic uses of vitamin K, its analogues and derivatives in a diverse array of disease conditions. Vitamin K improves blood perfusion and ameliorates hypoxia in prevention and treatment of conditions such as chronic venous insufficiency manifestations, post thrombotic syndrome, skin conditions related to melanization, hyperpigmentation, Paresthesiae, oedema, varicose veins, VTE and cramps. The invention also provides pharmaceutical compositions comprising vitamin K, its analogues, derivatives or vitamin K-like compounds either alone or in combination with one or more therapeutically effective active agents for the diseases/conditions of venous, nerves and lymph, that are encompassed by this invention.

    摘要翻译： 本发明涉及维生素K，其类似物和衍生物在多种疾病状况中的治疗用途。 维生素K改善血液灌注并改善预防和治疗诸如慢性静脉功能不全症，血栓形成后综合征，与黑化，色素沉着过度，感觉异常，浮肿，静脉曲张，VTE和痉挛有关的皮肤病症等缺氧症。 本发明还提供包含维生素K，其类似物，衍生物或维生素K样化合物的药物组合物，其单独或与用于静脉，神经和淋巴的疾病/病症的一种或多种治疗有效的活性剂组合 发明。