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公开(公告)号：US06479635B1
公开(公告)日：2002-11-12
申请号：US09577800
申请日：2000-05-24
IPC分类号： C07K100
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：US06528482B1
公开(公告)日：2003-03-04
申请号：US09466496
申请日：1999-12-17
IPC分类号： A61K3816
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：US06537763B2
公开(公告)日：2003-03-25
申请号：US09871856
申请日：2001-05-31
IPC分类号： G01N3353
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：US08569456B2
公开(公告)日：2013-10-29
申请号：US13424179
申请日：2012-03-19
IPC分类号： C07K14/71 , C07K14/435 , C07K19/00
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：US6017729A
公开(公告)日：2000-01-25
申请号：US996139
申请日：1997-12-22
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P29/00 , A61P37/02 , C07K14/52 , C07K14/525 , C07K14/705 , C07K14/715 , C07K16/24 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N5/20 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/19 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/566 , C07H21/04 , C12N15/63
CPC分类号： C07K16/241 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C12Q1/6876 , A61K38/00 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
摘要翻译： 公开了分离的受体，编码这些受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。 受体也可用于筛选其抑制剂。
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6.发明申请IMMUNOTHERAPEUTIC METHOD INVOLVING CD123 (IL-3Ra) ANTIBODIES AND IMMUNOSTIMULATING COMPLEX 有权涉及CD123（IL-3Ra）抗体和免疫组化复合物的免疫疗法公开(公告)号：US20130149303A1
公开(公告)日：2013-06-13
申请号：US13704583
申请日：2011-06-15
IPC分类号： A61K39/395
CPC分类号： A61K39/39533 , A61K39/39558 , A61K2039/505 , A61K2039/55577 , C07K16/2866 , A61K2300/00
摘要： A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
摘要翻译： 用于治疗患者中CD123表达细胞特征的病症的方法包括向患者施用（i）选择性结合IL-3Rα（CD123）的抗体或抗体片段，和（ii） 包含皂苷，固醇和磷脂的免疫刺激复合物。
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7.发明申请METHOD FOR MODIFYING CELLUAR IMMUNE RESONSE BY MODULATING ACTIVIN ACTIVITY 审中-公开通过调节活性活性来修饰细胞免疫调节的方法公开(公告)号：US20100279409A1
公开(公告)日：2010-11-04
申请号：US12733670
申请日：2008-09-11
IPC分类号： C12N5/0783
CPC分类号： C12N5/0639 , A61K39/39 , C12N2501/16
摘要： The invention relates to methods for modifying a cellular response, such as a CD8+ T cell or NK cell response, by adding an activin modulator in an amount sufficient to modulate activin production. By modulating this production, the cellular response is itself modulated.
摘要翻译： 本发明涉及通过加入足以调节激活素产生量的激活素调节剂来修饰细胞应答如CD8 + T细胞或NK细胞应答的方法。 通过调节这种生产，细胞反应本身被调节。
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公开(公告)号：US20130084282A1
公开(公告)日：2013-04-04
申请号：US13579886
申请日：2011-02-17
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/202 , A61K39/3955 , A61K51/1021 , A61K51/1033 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
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9.发明授权公开(公告)号：US06497876B1
公开(公告)日：2002-12-24
申请号：US09430448
申请日：1999-10-29
IPC分类号： A61K3512
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N5/0639 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/26 , C12N2501/52 , Y10S514/885
摘要： Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols. Other cytokines can be used in separate, sequential or simultaneous combination with the activated, antigen-pulsed dendritic cells. Also disclosed are methods for stimulating an immune response using the antigen-expressing, activated dendritic cells.
摘要翻译： 公开了表达抗原的活化树突状细胞。 这种树突状细胞用于向T细胞提供肿瘤，病毒或细菌抗原，并且可用于疫苗接种方案。 其他细胞因子可以与活化的抗原脉冲的树突状细胞分开，顺序或同时组合使用。 还公开了使用表达抗原的活化树突状细胞刺激免疫应答的方法。
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10.发明授权Immunotherapeutic method involving CD123 (IL-3Rα) antibodies and immunostimulating complex 有权涉及CD123（IL-3Rα）抗体和免疫刺激复合物的免疫治疗方法公开(公告)号：US08920803B2
公开(公告)日：2014-12-30
申请号：US13704583
申请日：2011-06-15
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39533 , A61K39/39558 , A61K2039/505 , A61K2039/55577 , C07K16/2866 , A61K2300/00
摘要： A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
摘要翻译： 用于治疗患者中CD123表达细胞特征的病症的方法包括向患者施用（i）选择性结合IL-3Rα（CD123）的抗体或抗体片段，和（ii） 包含皂苷，固醇和磷脂的免疫刺激复合物。
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