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1.发明授权公开(公告)号：US06497876B1
公开(公告)日：2002-12-24
申请号：US09430448
申请日：1999-10-29
IPC分类号： A61K3512
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N5/0639 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/26 , C12N2501/52 , Y10S514/885
摘要： Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols. Other cytokines can be used in separate, sequential or simultaneous combination with the activated, antigen-pulsed dendritic cells. Also disclosed are methods for stimulating an immune response using the antigen-expressing, activated dendritic cells.
摘要翻译： 公开了表达抗原的活化树突状细胞。 这种树突状细胞用于向T细胞提供肿瘤，病毒或细菌抗原，并且可用于疫苗接种方案。 其他细胞因子可以与活化的抗原脉冲的树突状细胞分开，顺序或同时组合使用。 还公开了使用表达抗原的活化树突状细胞刺激免疫应答的方法。
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公开(公告)号：US07150992B1
公开(公告)日：2006-12-19
申请号：US09699923
申请日：2000-10-30
申请人： David H. Lynch , Kenneth A. Brasel , Hilary J. McKenna , Luis G. Borges , Charles R. Maliszewski , Eugene Maraskovsky
发明人： David H. Lynch , Kenneth A. Brasel , Hilary J. McKenna , Luis G. Borges , Charles R. Maliszewski , Eugene Maraskovsky
CPC分类号： C12N5/0639 , A61K39/39541 , A61K2039/5154 , C12N2501/26 , A61K2300/00
摘要： Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic cells ex vivo. Such dendritic cells can then be used to present tumor, viral or other antigens to naive T cells, can be useful as vaccine adjuvants. When flt3-L is used and/or administered in combination with other reactive agents, e.g. CD40 binding proteins and 4-1BBL or antibodies reactive with 4-1BB, the combination further enhances immune responses and the effectiveness of vaccine adjuvants.
摘要翻译： Flt3-配体可用于从造血祖细胞和干细胞产生大量的树突状细胞。 Flt3-配体可用于增加体内的免疫应答，并离体扩展树突状细胞。 然后可以使用这种树突状细胞将肿瘤，病毒或其他抗原呈递给初始T细胞，可用作疫苗佐剂。 当使用flt3-L和/或与其它反应剂组合施用时， CD40结合蛋白和4-1BBL或与4-1BB反应的抗体，该组合进一步增强免疫应答和疫苗佐剂的有效性。
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公开(公告)号：US06479635B1
公开(公告)日：2002-11-12
申请号：US09577800
申请日：2000-05-24
IPC分类号： C07K100
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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4.发明申请IMMUNOTHERAPEUTIC METHOD INVOLVING CD123 (IL-3Ra) ANTIBODIES AND IMMUNOSTIMULATING COMPLEX 有权涉及CD123（IL-3Ra）抗体和免疫组化复合物的免疫疗法公开(公告)号：US20130149303A1
公开(公告)日：2013-06-13
申请号：US13704583
申请日：2011-06-15
IPC分类号： A61K39/395
CPC分类号： A61K39/39533 , A61K39/39558 , A61K2039/505 , A61K2039/55577 , C07K16/2866 , A61K2300/00
摘要： A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
摘要翻译： 用于治疗患者中CD123表达细胞特征的病症的方法包括向患者施用（i）选择性结合IL-3Rα（CD123）的抗体或抗体片段，和（ii） 包含皂苷，固醇和磷脂的免疫刺激复合物。
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5.发明申请METHOD FOR MODIFYING CELLUAR IMMUNE RESONSE BY MODULATING ACTIVIN ACTIVITY 审中-公开通过调节活性活性来修饰细胞免疫调节的方法公开(公告)号：US20100279409A1
公开(公告)日：2010-11-04
申请号：US12733670
申请日：2008-09-11
IPC分类号： C12N5/0783
CPC分类号： C12N5/0639 , A61K39/39 , C12N2501/16
摘要： The invention relates to methods for modifying a cellular response, such as a CD8+ T cell or NK cell response, by adding an activin modulator in an amount sufficient to modulate activin production. By modulating this production, the cellular response is itself modulated.
摘要翻译： 本发明涉及通过加入足以调节激活素产生量的激活素调节剂来修饰细胞应答如CD8 + T细胞或NK细胞应答的方法。 通过调节这种生产，细胞反应本身被调节。
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公开(公告)号：US20130084282A1
公开(公告)日：2013-04-04
申请号：US13579886
申请日：2011-02-17
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/202 , A61K39/3955 , A61K51/1021 , A61K51/1033 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
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公开(公告)号：US06528482B1
公开(公告)日：2003-03-04
申请号：US09466496
申请日：1999-12-17
IPC分类号： A61K3816
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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8.发明授权Immunotherapeutic method involving CD123 (IL-3Rα) antibodies and immunostimulating complex 有权涉及CD123（IL-3Rα）抗体和免疫刺激复合物的免疫治疗方法公开(公告)号：US08920803B2
公开(公告)日：2014-12-30
申请号：US13704583
申请日：2011-06-15
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39533 , A61K39/39558 , A61K2039/505 , A61K2039/55577 , C07K16/2866 , A61K2300/00
摘要： A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
摘要翻译： 用于治疗患者中CD123表达细胞特征的病症的方法包括向患者施用（i）选择性结合IL-3Rα（CD123）的抗体或抗体片段，和（ii） 包含皂苷，固醇和磷脂的免疫刺激复合物。
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公开(公告)号：US08569456B2
公开(公告)日：2013-10-29
申请号：US13424179
申请日：2012-03-19
IPC分类号： C07K14/71 , C07K14/435 , C07K19/00
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：US6017527A
公开(公告)日：2000-01-25
申请号：US763995
申请日：1996-12-12
IPC分类号： A61K38/00 , C07K14/705 , C12N5/0784 , A01N63/00 , C12N5/10
CPC分类号： C12N5/0639 , C07K14/70575 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K38/00 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/26 , C12N2501/52
摘要： Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols. Other cytokines can be used in separate, sequential or simultaneous combination with the activated, antigen-pulsed dendritic cells. Also disclosed are methods for stimulating an immune response using the antigen-expressing, activated dendritic cells.
摘要翻译： 公开了表达抗原的活化树突状细胞。 这种树突状细胞用于向T细胞提供肿瘤，病毒或细菌抗原，并且可用于疫苗接种方案。 其他细胞因子可以与活化的抗原脉冲的树突状细胞分开，顺序或同时组合使用。 还公开了使用表达抗原的活化树突状细胞刺激免疫应答的方法。
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