专利检索 ap:("Dominic King-Smith" OR "Bradley S. Galer" OR "John M. Newsam" OR "Nadir Buyuktimkin" OR "Edward T. Kisak" OR "Jagat Singh") AND inv:"Jagat Singh" 第 1 页

1.

发明申请
TOPICAL IBUPROFEN FORMULATIONS 失效
标题翻译：主题IBUPROFEN配方

公开(公告)号：US20120232152A1

公开(公告)日：2012-09-13

申请号：US13511287

申请日：2010-11-26

申请人： Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Edward T. Kisak , Jagat Singh

发明人： Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Edward T. Kisak , Jagat Singh

IPC分类号： A61K31/192 , A61P29/00

CPC分类号： A61K31/192 , A61K9/0014 , A61K47/10 , A61K47/14

摘要： The present application relates to a topical formulation comprising ibuprofen, a hydroalcoholic based solvent system, a C1-4alcohol ester of citric acid, and a surfactant. The formulation shows physical stability over more than one month at ambient temperature and is colourless, essentially odorless, and has a pH value of about 6.5. The formulation of the application shows two to four times improved ibuprofen flux compared to a standard composition.

摘要翻译： 本申请涉及包含布洛芬，基于水醇的溶剂体系，柠檬酸的C 1-4醇酯和表面活性剂的局部制剂。该配方在环境温度下显示超过一个月的物理稳定性，为无色，基本上无臭，pH值约为6.5。与标准组合物相比，该应用的配方显示了改善的布洛芬通量的2-4倍。

2.

发明授权
Topical ibuprofen formulations 失效
标题翻译：外用布洛芬配方

公开(公告)号：US08470886B2

公开(公告)日：2013-06-25

申请号：US13511287

申请日：2010-11-26

申请人： Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Servet Buyuktimkin , Edward T. Kisak , Jagat Singh

发明人： Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Servet Buyuktimkin , Edward T. Kisak , Jagat Singh

IPC分类号： A61K31/192

CPC分类号： A61K31/192 , A61K9/0014 , A61K47/10 , A61K47/14

摘要： The present application relates to a topical formulation comprising ibuprofen, a hydroalcoholic based solvent system, a C1-4alcohol ester of citric acid, and a surfactant. The formulation shows physical stability over more than one month at ambient temperature and is colorless, essentially odorless, and has a pH value of about 6.5. The formulation of the application shows two to four times improved ibuprofen flux compared to a standard composition.

摘要翻译： 本申请涉及包含布洛芬，基于水醇的溶剂体系，柠檬酸的C 1-4醇酯和表面活性剂的局部制剂。该配方在环境温度下显示超过一个月的物理稳定性，为无色，基本上无臭，pH值约为6.5。与标准组合物相比，该应用的配方显示了改善的布洛芬通量的2-4倍。

3.

发明申请
FORMULATIONS FOR THE TREATMENT OF ACUTE HERPES ZOSTER PAIN 审中-公开
标题翻译：治疗急性肝炎闭塞性疼痛的配方

公开(公告)号：US20110288123A1

公开(公告)日：2011-11-24

申请号：US13127470

申请日：2009-11-05

申请人： Edward T. Kisak , R. Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Servet Buyuktimkin , Jagat Singh

发明人： Edward T. Kisak , R. Dominic King-Smith , Bradley S. Galer , John M. Newsam , Nadir Buyuktimkin , Servet Buyuktimkin , Jagat Singh

IPC分类号： A61K31/47 , A61K31/167 , A61P29/00 , A61K31/24 , A61P23/00 , A61K31/245 , A61K31/445

CPC分类号： A61K31/167 , A61K9/0014 , A61K47/10 , A61K47/26

摘要： The present invention provides compositions and methods that are useful for treatment of pain associated with acute herpes zoster. The aqueous compositions are non-stinging and non-irritating.

摘要翻译： 本发明提供了可用于治疗与急性带状疱疹相关的疼痛的组合物和方法。含水组合物是非刺激性且无刺激性的。

4.

发明授权
Foamable formulation 有权
标题翻译：可发泡制剂

公开(公告)号：US09107823B2

公开(公告)日：2015-08-18

申请号：US13605734

申请日：2012-09-06

申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward Kisak , Jagat Singh , John M. Newsam , Dominic King-Smith , Bradley S. Galer

发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward Kisak , Jagat Singh , John M. Newsam , Dominic King-Smith , Bradley S. Galer

IPC分类号： A61K9/12 , A61K31/10 , A61K31/56 , A61K9/00 , A61K31/192 , A61K31/196 , A61K47/10 , A61K47/20

CPC分类号： A61K9/122 , A61K9/0014 , A61K31/10 , A61K31/192 , A61K31/196 , A61K31/56 , A61K47/10 , A61K47/20

摘要： The present invention provides DMSO-containing foamable formulations, methods for preparation, and methods of treatment. The formulations can provide good permeability and bioavailability at the target site. Preferably, the formulations are useful for treating osteoarthritis. In one embodiment, the invention provides a foamable formulation for topical use, said formulation comprising DMSO, polyalkylene glycol alkyl ether, an active agent, a monohydric lower alcohol, a diol, and water. Preferably, the active agent is a non-steroidal anti-inflammatory drug, such as diclofenac sodium or ibuprofen.

摘要翻译： 本发明提供含DMSO的可发泡制剂，制备方法和治疗方法。制剂可以在目标部位提供良好的渗透性和生物利用度。优选地，该制剂可用于治疗骨关节炎。在一个实施方案中，本发明提供了用于局部使用的可发泡制剂，所述制剂包含DMSO，聚亚烷基二醇烷基醚，活性剂，一元低级醇，二醇和水。优选地，活性剂是非甾体抗炎药，例如双氯芬酸钠或布洛芬。

5.

发明申请
PHARMACEUTICAL FORMULATIONS AND METHODS OF USE 审中-公开
标题翻译：药物制剂及其使用方法

公开(公告)号：US20120214874A1

公开(公告)日：2012-08-23

申请号：US13392498

申请日：2010-08-26

申请人： Nadir Buyuktimkin , Servet Buyuktimkin , Jagat Singh , John M. Newsam , Dominic King-Smith , Edward Kisak , Bradley S. Galer , Tejas Desai , Christopher Riley

发明人： Nadir Buyuktimkin , Servet Buyuktimkin , Jagat Singh , John M. Newsam , Dominic King-Smith , Edward Kisak , Bradley S. Galer , Tejas Desai , Christopher Riley

IPC分类号： A61K31/167 , A61K47/22 , A61P23/00 , A61K47/14

CPC分类号： A61K31/167 , A61K9/0014 , A61K9/107 , A61K47/14 , A61K47/26

摘要： In one embodiment, the present invention provides a topical composition including a topically acting anesthetic active ingredient; an ester; a non-ionic surfactant; a polar solvent; water, and optionally a buffer, a pH adjusting agent or an anti-oxidant. The compositions are useful for alleviating pain especially associated with acute herpes zoster.

摘要翻译： 在一个实施方案中，本发明提供了包含局部作用的麻醉活性成分的局部组合物; 酯; 非离子表面活性剂; 极性溶剂; 水和任选的缓冲剂，pH调节剂或抗氧化剂。该组合物可用于缓解特别与急性带状疱疹相关的疼痛。

6.

发明申请
FOAMABLE FORMULATION 有权

公开(公告)号：US20130243701A1

公开(公告)日：2013-09-19

申请号：US13605734

申请日：2012-09-06

申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward Kisak , Jagat Singh , John M. Newsam , Dominic King-Smith , Bradley S. Galer

发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward Kisak , Jagat Singh , John M. Newsam , Dominic King-Smith , Bradley S. Galer

IPC分类号： A61K9/12

CPC分类号： A61K9/122 , A61K9/0014 , A61K31/10 , A61K31/192 , A61K31/196 , A61K31/56 , A61K47/10 , A61K47/20

摘要： The present invention provides DMSO-containing foamable formulations, methods for preparation, and methods of treatment. The formulations can provide good permeability and bioavailability at the target site. Preferably, the formulations are useful for treating osteoarthritis. In one embodiment, the invention provides a foamable formulation for topical use, said formulation comprising DMSO, polyalkylene glycol alkyl ether, an active agent, a monohydric lower alcohol, a diol, and water. Preferably, the active agent is a non-steroidal anti-inflammatory drug, such as diclofenac sodium or ibuprofen.

7.

发明申请
FOAMABLE COMPOSITIONS OF STABILIZED CHLORITE 审中-公开
标题翻译：稳定化氯化物的可燃组合物

公开(公告)号：US20130136805A1

公开(公告)日：2013-05-30

申请号：US13816056

申请日：2011-08-12

申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin

发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin

IPC分类号： A61K9/12

CPC分类号： A61K9/122 , A61K9/0014 , A61K33/00 , A61K47/02 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38

摘要： The present application relates to foamable compositions and foams comprising stabilized chlorite, including stabilized chlorite solutions such as Oxovasin™, and to medical uses thereof, in particular for wound healing. The foamable compositions comprise at least one foaming agent, stabilized chlorite, water and optionally, a buffering agent.

摘要翻译： 本发明涉及可发泡组合物和包含稳定的亚氯酸盐的泡沫，包括稳定的亚氯酸盐溶液，例如Oxovasin TM，以及其医疗用途，特别是用于伤口愈合。可发泡组合物包含至少一种发泡剂，稳定的亚氯酸盐，水和任选的缓冲剂。

8.

发明申请
WOUND DRESSINGS COMPRISING CHLORITE 审中-公开
标题翻译：包括氯化物的连衣裙

公开(公告)号：US20130316020A1

公开(公告)日：2013-11-28

申请号：US13984443

申请日：2012-02-09

申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , Dominic King-Smith , John M. Newsam , Jagat Singh

发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , Dominic King-Smith , John M. Newsam , Jagat Singh

IPC分类号： A61L15/44

CPC分类号： A61L15/44 , A61L15/26 , A61L15/425 , A61L15/46 , A61L2300/106 , A61L2300/404 , C08L75/04

摘要： This application described a wound dressing comprising an absorbent material, an effective amount of chlorite and an amount of a base to provide a pH of the dressing material greater than or equal to about (10). Advantageously, the wound dressings of the present application provide a convenient source of chlorite that is stable and easy to use.

摘要翻译： 本申请描述了包含吸收材料，有效量的亚氯酸盐和一定量的基底的伤口敷料，以提供大于或等于约（10）的敷料材料的pH。有利地，本申请的伤口敷料提供了稳定且易于使用的方便的绿泥石源。