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公开(公告)号:US20110313003A1
公开(公告)日:2011-12-22
申请号:US12817116
申请日:2010-06-16
申请人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
发明人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
IPC分类号: A61K31/44 , A61K31/343 , A61P3/10 , C12N5/00 , C07D311/58 , A61K31/352 , C07D319/08 , A61K31/357 , C07D405/10 , A61K31/41 , C07D333/54 , A61K31/381 , C07D307/94 , C07D211/76 , C07D231/56 , A61K31/416 , C07D307/79
CPC分类号: C07D209/08 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/41 , A61K31/416 , A61K31/44 , C07B59/002 , C07D211/76 , C07D231/56 , C07D307/79 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D405/10
摘要: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要翻译: 提供GPR120激动剂。 这些化合物可用于治疗代谢疾病,包括II型糖尿病和与血糖控制不良相关的疾病。
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公开(公告)号:US20100190831A1
公开(公告)日:2010-07-29
申请号:US12641263
申请日:2009-12-17
申请人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
发明人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
IPC分类号: A61K31/44 , C07D307/79 , A61K31/343 , A61P3/10 , C07D311/58 , A61K31/352 , C07D319/08 , A61K31/357 , C07D307/83 , C07D405/10 , A61K31/41 , C07D333/60 , A61K31/381 , C07D307/94 , C07D213/643
CPC分类号: C07D405/04 , C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D333/60 , C07D405/10 , C07D407/04 , C07D407/12
摘要: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要翻译: 提供GPR120激动剂。 这些化合物可用于治疗代谢疾病,包括II型糖尿病和与血糖控制不良相关的疾病。
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公开(公告)号:US08309600B2
公开(公告)日:2012-11-13
申请号:US12641263
申请日:2009-12-17
申请人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
发明人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
IPC分类号: A61K31/343 , C07D307/83
CPC分类号: C07D405/04 , C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D333/60 , C07D405/10 , C07D407/04 , C07D407/12
摘要: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
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公开(公告)号:US08299117B2
公开(公告)日:2012-10-30
申请号:US12817116
申请日:2010-06-16
申请人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
发明人: Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
IPC分类号: A61K31/343 , C07D307/83
CPC分类号: C07D209/08 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/41 , A61K31/416 , A61K31/44 , C07B59/002 , C07D211/76 , C07D231/56 , C07D307/79 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D405/10
摘要: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要翻译: 提供GPR120激动剂。 这些化合物可用于治疗代谢疾病,包括II型糖尿病和与血糖控制不良相关的疾病。
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公开(公告)号:US20100216827A1
公开(公告)日:2010-08-26
申请号:US12582610
申请日:2009-10-20
申请人: Jingyuan Ma , Aaron Novack , Imad Nashashibi , Phuongly Pham , Christopher J. Rabbat , Jiangao Song , Dong Fang Shi , Zuchun Zhao , Yun-Jung Choi , Xin Chen
发明人: Jingyuan Ma , Aaron Novack , Imad Nashashibi , Phuongly Pham , Christopher J. Rabbat , Jiangao Song , Dong Fang Shi , Zuchun Zhao , Yun-Jung Choi , Xin Chen
IPC分类号: A61K31/506 , C07D231/12 , A61K31/415 , C07D285/06 , A61K31/433 , C07D233/54 , A61K31/4164 , C07D403/04 , A61P3/10
CPC分类号: C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D263/32 , C07D277/24 , C07D285/06 , C07D307/42 , C07D333/16 , C07D409/04
摘要: Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要翻译: 提供Aryl GPR120激动剂。 这些化合物可用于治疗代谢疾病,包括II型糖尿病和与血糖控制不良相关的疾病。
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6.N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译: 用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂公开(公告)号:US08183381B2
公开(公告)日:2012-05-22
申请号:US12171209
申请日:2008-07-10
申请人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号: C07D401/00
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译: 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。
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7.N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译: 用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂公开(公告)号:US08846675B2
公开(公告)日:2014-09-30
申请号:US13463617
申请日:2012-05-03
申请人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号: A61K31/535 , C07D401/14 , C07D413/14 , C07D401/04 , C07D417/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译: 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。
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8.N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译: 用于治疗糖尿病和代谢障碍的N-连锁异位受体激动剂公开(公告)号:US20120322804A1
公开(公告)日:2012-12-20
申请号:US13463617
申请日:2012-05-03
申请人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号: A61K31/454 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/4545 , C12N5/0783 , A61K31/5377 , A61K31/4709 , C07D451/02 , A61K31/46 , A61P3/10 , C12N5/071 , C07D401/04 , C07D417/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译: 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。
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9.N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译: 用于治疗糖尿病和代谢障碍的N-连锁异位受体激动剂公开(公告)号:US20090137590A1
公开(公告)日:2009-05-28
申请号:US12171209
申请日:2008-07-10
申请人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人: Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号: A61K31/5377 , C07D401/04 , A61K31/454 , A61K31/506 , C12N5/06 , C07D401/14 , C07D413/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译: 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。
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公开(公告)号:US20130059856A1
公开(公告)日:2013-03-07
申请号:US13495878
申请日:2012-06-13
申请人: Aaron Robert Novack , Dong-Fang Shi , Jingyuan Ma , Imad Nashashibi , Phuongly Pham , Jiangao Song , David W. G. Wone , Xueyan Wang , Jeffrey D. Johnson , Brian Edward Lavan , Charles A. McWherter , Xin Chen
发明人: Aaron Robert Novack , Dong-Fang Shi , Jingyuan Ma , Imad Nashashibi , Phuongly Pham , Jiangao Song , David W. G. Wone , Xueyan Wang , Jeffrey D. Johnson , Brian Edward Lavan , Charles A. McWherter , Xin Chen
IPC分类号: A61K31/4164 , C07D403/12 , A61K31/4178 , C07D401/12 , A61K31/4439 , A61P3/10 , C07D401/14 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/4985 , C07D233/90 , A61K31/454
CPC分类号: C07D233/90 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
摘要翻译: 公开了作为GPR131的激动剂或其它调节活性的化合物。 还描述了相关的组合物,制剂和使用方法。
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