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公开(公告)号：US20050089840A1
公开(公告)日：2005-04-28
申请号：US10667966
申请日：2003-09-23
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的gp41肽衍生物。 特别地，本发明涉及具有抑制人体免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）的活性的gp41衍生物，其具有用于治疗各自病毒感染的作用持续时间。
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公开(公告)号：US20110003735A1
公开(公告)日：2011-01-06
申请号：US12567250
申请日：2009-09-25
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的gp41肽衍生物。 特别地，本发明涉及具有抑制人体免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）的活性的gp41衍生物，其具有用于治疗各自病毒感染的作用持续时间。
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3.发明授权Human immunodeficiency virus (HIV) gp41 peptide derivatives with enhanced solubility and antiviral activity 有权人类免疫缺陷病毒（HIV）gp41肽衍生物具有增强的溶解度和抗病毒活性公开(公告)号：US07575750B2
公开(公告)日：2009-08-18
申请号：US10667966
申请日：2003-09-23
IPC分类号： A61K39/385 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的gp41肽衍生物。 特别地，本发明涉及具有抑制人体免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）的活性的gp41衍生物，其具有用于治疗各自病毒感染的作用持续时间。
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4.发明授权Method of inhibiting HIV-1 replication by administering modified GP41 C34 peptide derivatives with enhanced pharmacological properties 有权通过施用具有增强的药理学性质的修饰的GP41 C34肽衍生物来抑制HIV-1复制的方法公开(公告)号：US08470527B2
公开(公告)日：2013-06-25
申请号：US12567250
申请日：2009-09-25
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1.
摘要翻译： 所要求保护的发明涉及修饰的HIV-1 gp41 C-末端七重复重组融合抑制剂。 特别地，制备C-34的肽衍生物（例如FB006M）并用3-马来酰亚胺酸（MPA）修饰，其允许以1:1摩尔比快速和不可逆地与血清白蛋白缀合。 这些多肽在体内具有延长的半衰期，并显示针对HIV-1的有效的抗病毒活性。
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5.发明授权Fuel injector regulator having combined initial injection and peak injection pressure regulation 有权燃油喷射调节器具有组合的初始喷射和峰值喷射压力调节公开(公告)号：US07097115B2
公开(公告)日：2006-08-29
申请号：US11003629
申请日：2004-12-03
申请人： He Jiang , Gerald Gaydek
发明人： He Jiang , Gerald Gaydek
CPC分类号： F02M45/12 , F02M45/02 , F02M45/08 , F02M57/02 , F02M63/0049
摘要： A fuel injector regulator having combined initial injection and peak injection pressure regulation. The fuel injector regulator includes a rate shaping valve movably supported within a valve bore between a closed position and an open position to regulate a rate of injected fuel. The regulator further includes a waste gate valve having a body movably supported within a bore of the rate shaping valve and between a closed position and an open position to regulate the pressure of injected fuel.
摘要翻译： 具有组合的初始注入和峰值注入压力调节的燃料喷射器调节器。 燃料喷射器调节器包括速率成形阀，其可移动地支撑在关闭位置和打开位置之间的阀孔内，以调节喷射燃料的速率。 该调节器还包括一个废物闸阀，其具有可移动地支撑在速率整形阀的孔内且在关闭位置和打开位置之间的主体，以调节喷射的燃料的压力。
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公开(公告)号：US06390069B1
公开(公告)日：2002-05-21
申请号：US09769969
申请日：2001-01-26
申请人： He Jiang , Xiaobin Li
发明人： He Jiang , Xiaobin Li
IPC分类号： F02M3704
CPC分类号： F02M45/06 , F02M45/12 , F02M57/023 , F02M59/366 , F02M59/468 , F02M2200/502
摘要： A fuel injector assembly is provided which includes a control valve actuated by a piezoelectric actuator acting through a hydraulic amplifier to facilitate pressurization of fluid fuel within the fuel injector assembly for dispersing the fuel into a combustion chamber. The piezoelectric actuator is excited by a variable voltage source to control the degree of displacement of the hydraulic amplifier to control the degree of fluid fuel dispersement by controlling the degree of displacement of the control valve. The configuration of the control valve may be such as to provide multi-step fluid fuel dispersing thereby providing a low fuel injection pressure and rate followed by a higher fuel injection pressure and rate. Multi-step fluid fuel dispersing may also be accomplished by varying the level of excitation voltage to the piezoelectric actuator. A pressure check valve is provided to prime the hydraulic amplifier cavity, to expel trapped air therefrom, to compensate for fuel leakages from the cavity and to circulate fuel through the cavity. An internal combustion engine including such a fuel injector assembly is also provided.
摘要翻译： 提供了一种燃料喷射器组件，其包括由通过液压放大器起作用的压电致动器致动的控制阀，以便于燃料喷射器组件内的流体燃料的加压，以将燃料分散到燃烧室中。 压电致动器被可变电压源激励以通过控制控制阀的位移程度来控制液压放大器的位移程度以控制流体燃料分散的程度。 控制阀的结构可以是提供多级流体燃料分散，从而提供低燃料喷射压力和速率，随后更高的燃料喷射压力和速率。 也可以通过改变对压电致动器的激励电压的水平来实现多级流体燃料分散。 提供一个压力止回阀，用于引导液压放大器腔，以从中排出被捕获的空气，以补偿来自空腔的燃料泄漏并使燃料循环通过空腔。 还提供了包括这种燃料喷射器组件的内燃机。
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公开(公告)号：US07628139B2
公开(公告)日：2009-12-08
申请号：US11484415
申请日：2006-07-11
申请人： Kayhan Halil Göney , He Jiang , Yury Kalish
发明人： Kayhan Halil Göney , He Jiang , Yury Kalish
IPC分类号： F02M59/46
CPC分类号： F02M57/023 , F02M47/027 , F02M63/0026
摘要： A fuel injector 10 for a Diesel engine has a plunger 12 and two control valves 20 and 30 for controlling the injection of fuel from the main supply cavity to the discharge port 52. Each control valve 20 and 30 are actuated through piezo-electric stacks 34 and 74 connected to a electronic variable voltage supply 33.
摘要翻译： 用于柴油发动机的燃料喷射器10具有柱塞12和用于控制从主供应腔向排出口52喷射燃料的两个控制阀20和30.每个控制阀20和30通过压电堆34 74连接到电子可变电压源33。
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公开(公告)号：US06247450B1
公开(公告)日：2001-06-19
申请号：US09472284
申请日：1999-12-27
申请人： He Jiang
发明人： He Jiang
IPC分类号： F02M3704
CPC分类号： F02M63/0225 , F02M57/023 , F02M63/0007
摘要： A fuel injection system, comprising a low pressure fuel delivery pump with constant output in fluid communication with a low pressure fuel line; said fuel line connected to an electronic controlled fuel pressure regulator and fuel pressure sensor; an electronic control module to monitor and adjust fuel pressure in said low pressure fuel line to a desired fuel delivery pressure and supply fuel to an injector at a feed-back controlled pressure; and at least one injector in fluid communication with a cylinder in an internal combustion engine; said injector having an injector body equipped with a fuel metering orifice to supply fuel from the fuel line to a fuel cumulative chamber within the injector, a reciprocating plunger within said injector; said plunger equipped with a plunger; said plunger passage opening at one end to said fuel cumulative chamber, and, upon reciprocation of the plunger within the injector, opening at its other end to said metering orifice; said injector further equipped with an electronically controlled solenoid control valve to operate a fuel needle within said injector to inflict fuel into said engine cylinder; and a camshaft at least one cam lobe to drive said injector plungers; said cam lobe having a base circle section to meter fuel for injection; a rising section for pressurizing fuel in the cumulative chamber; a zero velocity section of sufficient length to accommodate a variety of fuel injection timing sequences, and a falling section; said camshaft interactive with a rocker arm to drive said plunger and inject fuel into said engine cylinder.
摘要翻译： 一种燃料喷射系统，包括具有与低压燃料管线流体连通的恒定输出的低压燃料输送泵; 所述燃料管线连接到电子控制的燃料压力调节器和燃料压力传感器;电子控制模块，用于监测和调节所述低压燃料管线中的燃料压力至期望的燃料输送压力，并在反馈控制下向喷射器供应燃料 压力; 以及与内燃机中的气缸流体连通的至少一个喷射器; 所述注射器具有装备有燃料计量孔口的喷射器主体，用于将来自燃料管线的燃料供应到喷射器内的燃料累积室，所述喷射器内的往复式柱塞; 所述柱塞装有柱塞; 所述柱塞通道在一端打开到所述燃料累积室，并且当所述柱塞在所述喷射器内往复运动时，其另一端在所述计量孔口处开口; 所述喷射器还配备有电子控制的电磁控制阀，以在所述喷射器内操作燃料针以将燃料引入所述发动机气缸; 和凸轮轴至少一个凸轮凸角以驱动所述喷射器柱塞; 所述凸轮凸角具有用于计量喷射燃料的基圆部分; 用于对累积室中的燃料加压的上升段; 具有足够长度以适应各种燃料喷射正时序列的零速度部分和下降部分; 所述凸轮轴与摇臂相互作用以驱动所述柱塞并将燃料喷射到所述发动机气缸中。
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公开(公告)号：US20080011274A1
公开(公告)日：2008-01-17
申请号：US11484415
申请日：2006-07-11
申请人： Kayhan Halil Goney , He Jiang , Yury Kalish
发明人： Kayhan Halil Goney , He Jiang , Yury Kalish
CPC分类号： F02M57/023 , F02M47/027 , F02M63/0026
摘要： A fuel injector 10 for a Diesel engine has a plunger 12 and two control valves 20 and 30 for controlling the injection of fuel from the main supply cavity to the discharge port 52. Each control valve 20 and 30 are actuated through piezo-electric stacks 34 and 74 connected to a electronic variable voltage supply 33.
摘要翻译： 用于柴油发动机的燃料喷射器10具有柱塞12和用于控制从主供应腔向排出口52喷射燃料的两个控制阀20和30.每个控制阀20和30通过压电堆34 74连接到电子可变电压源33。
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10.发明申请公开(公告)号：US20060118659A1
公开(公告)日：2006-06-08
申请号：US11003629
申请日：2004-12-03
申请人： He Jiang , Gerald Gaydek
发明人： He Jiang , Gerald Gaydek
IPC分类号： F02M63/00
CPC分类号： F02M45/12 , F02M45/02 , F02M45/08 , F02M57/02 , F02M63/0049
摘要： A fuel injector regulator having combined initial injection and peak injection pressure regulation. The fuel injector regulator includes a rate shaping valve movably supported within a valve bore between a closed position and an open position to regulate a rate of injected fuel. The regulator further includes a waste gate valve having a body movably supported within a bore of the rate shaping valve and between a closed position and an open position to regulate the pressure of injected fuel.
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