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公开(公告)号：US06632646B1
公开(公告)日：2003-10-14
申请号：US09678867
申请日：2000-10-02
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
IPC分类号： C12N950
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 提出了通过突变多个枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因产生的酶。与其野生型亲本酶相比，酶显示改善的洗涤性能。酶是良好的 - 用于洗涤剂组合物。
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公开(公告)号：US06197567B1
公开(公告)日：2001-03-06
申请号：US08815775
申请日：1997-03-12
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
IPC分类号： C12N954
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzyme exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 提出了通过突变多个枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因产生的酶。与其野生型亲本酶相比，酶显示出改进的洗涤性能。酶非常适合用于洗涤剂组合物中。
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公开(公告)号：US5665587A
公开(公告)日：1997-09-09
申请号：US484190
申请日：1995-06-07
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif N.o slashed.rskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif N.o slashed.rskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： The present invention relates to modified subtilisins comprising a mutation in an amino acid sequence of a subtilisin at a position selected from the group consisting of 1, 2, 3, 4, 6, 9, 10, 12, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 27, 36, 37, 38, 40, 41, 43, 44, 45, 46, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 75, 76, 77, 78, 79, 87, 89, 91, 94, 97, 98, 99, 100, 101, 103, 104, 105, 106, 107, 108, 109, 112, 113, 115, 116, 117, 118, 120, 126, 128, 129, 130, 131, 133, 134, 136, 137, 140, 141, 143, 144, 145, 146, 155, 156, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 170, 171, 172, 173, 181, 182, 183, 184, 185, 186, 188, 189, 191, 192, 194, 195, 197, 204, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 265, 269, 271, 272 and 275. The present invention also relates to detergent compositions comprising a modified subtilisin of the present invention.
摘要翻译： 本发明涉及包含在选自1,2,3,4,6,9,10,12,14,15,17,18中的位置的枯草杆菌蛋白酶的氨基酸序列突变的修饰的枯草杆菌蛋白酶 ，19，20，21，22，24，25，27，36，37，38，40，41，43，44，45，46，49，50，51，52，53，54，55，56，57 ，58，59，60，61，62，75，76，77，78，79，87，89，91，94，97，98，99，100，101，103，104，105，106，107，108 ，109,112,113,115,116,117,118,120,126,128,129,130,131,133,134,136,137,140,141,143,144,145,146,155,156 ，158,159,160,161,162,163,164,165,166,167,170,171,172,173,181,182,183,184,185,186,188,189,191,192,194 ，195,197,204,206,29,210,211,212,213,214,215,216,217,218,235,236,237,238,239,240,241,242,243,244,245 ，247,248,249,251,252,253,254,255,256,257,259,260,261,262,263,265,269,271,272和275.本发明还涉及洗涤剂组合物，其包含 p的修饰的枯草杆菌蛋白酶 重申发明。
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公开(公告)号：US07189553B2
公开(公告)日：2007-03-13
申请号：US10314191
申请日：2002-12-06
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Norskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Castelijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Norskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Castelijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 本发明涉及通过突变多种枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因而产生的酶。 与其野生型亲本酶相比，酶显示改善的洗涤性能。 酶非常适合用于洗涤剂组合物中。
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公开(公告)号：US5631217A
公开(公告)日：1997-05-20
申请号：US527734
申请日：1995-09-13
申请人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
发明人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
摘要： This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.
摘要翻译： 本发明涉及酶，适用于例如其生产的rDNA技术，可用于其生产的突变基因，载体和突变和转化的微生物以及其用途，包括例如含有它们的酶洗涤剂和清洁组合物。
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公开(公告)号：US5482849A
公开(公告)日：1996-01-09
申请号：US811502
申请日：1991-12-20
申请人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
发明人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
摘要： This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.
摘要翻译： 本发明涉及酶，适用于例如其生产的rDNA技术，可用于其生产的突变基因，载体和突变和转化的微生物以及其用途，包括例如含有它们的酶洗涤剂和清洁组合物。
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公开(公告)号：US06835821B2
公开(公告)日：2004-12-28
申请号：US10310730
申请日：2002-12-05
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
IPC分类号： C12N1557
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.
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公开(公告)号：US20050003986A1
公开(公告)日：2005-01-06
申请号：US10896177
申请日：2004-07-21
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Petersen , Leif Norskov-Lauridsen , Villy Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Petersen , Leif Norskov-Lauridsen , Villy Jensen , Dorrit Aaslyng
IPC分类号： C12N15/09 , C11D3/386 , C11D7/42 , C12N1/21 , C12N9/50 , C12N9/54 , C12N9/56 , C12N15/00 , C12N15/57 , C12P21/02 , C12R1/07 , C12R1/125 , C07H21/04 , C12N15/74 , C12Q1/68
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.
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公开(公告)号：US06908991B2
公开(公告)日：2005-06-21
申请号：US10313853
申请日：2002-12-06
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Norskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Norskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
IPC分类号： C12N15/09 , C11D3/386 , C11D7/42 , C12N1/21 , C12N9/50 , C12N9/54 , C12N9/56 , C12N15/00 , C12N15/57 , C12P21/02 , C12R1/07 , C12R1/125 , C12N15/75
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.
摘要翻译： 本发明涉及导致枯草杆菌蛋白酶的化学特性变化的枯草杆菌蛋白酶基因的突变。 枯草杆菌蛋白酶基因的特异性核酸的突变导致氨基酸取代，从而导致酶功能的改变。 这些突变体酶中的一些显示出对于工业应用有利的物理性质，特别是在洗涤剂工业中，提供对氧化更稳定的枯草杆菌蛋白酶，具有更大的蛋白酶活性，并且表现出改进的可洗性。
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公开(公告)号：US06808913B2
公开(公告)日：2004-10-26
申请号：US10306089
申请日：2002-11-27
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjørn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjørn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
IPC分类号： C12N954
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.
摘要翻译： 本发明涉及导致枯草杆菌蛋白酶的化学特性变化的枯草杆菌蛋白酶基因的突变。 枯草杆菌蛋白酶基因的特异性核酸的突变导致氨基酸取代，从而导致酶功能的改变。 这些突变体酶中的一些显示出对于工业应用有利的物理性质，特别是在洗涤剂工业中，提供对氧化更稳定的枯草杆菌蛋白酶，具有更大的蛋白酶活性，并且表现出改进的可洗性。
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