公开(公告)号：US5453378A

公开(公告)日：1995-09-26

申请号：US201372

申请日：1994-02-24

申请人： Douglas E. Bell ,  Amy H. Chu ,  Karen L. Marfurt

发明人： Douglas E. Bell ,  Amy H. Chu ,  Karen L. Marfurt

IPC分类号： G01N33/50 ,  G01N33/66 ,  G01N33/96 ,  G01N31/00

CPC分类号： G01N33/96 ,  G01N33/66 ,  Y10T436/10 ,  Y10T436/103332 ,  Y10T436/104165 ,  Y10T436/104998 ,  Y10T436/105831 ,  Y10T436/106664

摘要： Disclosed is a serum free control reagent formulation useful for the determination of a pre-selected analyte. The formulation involves an aqueous solution of a predetermined amount of the analyte together with a polymerized quaternary salt of di- or mono- allyl, di- or tri- alkyl ammonium characterized by the formulae: ##STR1## where R is straight or branched chain alkyl of 1 to 4 carbon atoms, n is a number of at least 9 and .theta. represents a counteranion. The formulation typically contains a buffer to maintain its pH at a level of about 7.5 and a preservative.

摘要翻译： 公开了一种无血清对照试剂制剂，可用于测定预先选择的分析物。 该制剂包含预定量的分析物的水溶液以及二烯丙基，二或三烷基铵的聚合季盐，其特征为下列结构式：其中R为直链 或1至4个碳原子的支链烷基，n是至少9的数，θ表示抗衡阴离子。 该制剂通常含有缓冲液以将其pH保持在约7.5的水平和防腐剂。

公开(公告)号：US5360595A

公开(公告)日：1994-11-01

申请号：US108295

申请日：1993-08-19

申请人： Douglas E. Bell ,  Amy H. Chu

发明人： Douglas E. Bell ,  Amy H. Chu

IPC分类号： C12Q1/00 ,  C12Q1/32 ,  C12Q1/48 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66 ,  G01N21/00

CPC分类号： G01N33/521

摘要： Disclosed is an improved procedure for the manufacture of a diagnostic test device comprising a matrix having uniformly dispersed a tetrazolium salt and a reagent system designed to convert the tetrazolium to its colored formazan upon contacting the matrix with a fluid containing an analyte whose presence and/or concentration is being sought. The procedure involves applying the tetrazolium salt to the matrix from its solution in an organic solvent and, after drying, applying the reagent system to the matrix from its aqueous solution to which has been added hexanesulfonate as wetting agent.

摘要翻译： 公开了一种用于制造诊断测试装置的改进方法，所述方法包括具有均匀分散的四唑盐的基质和设计用于在将基质与含有分析物的流体接触时将四唑鎓转化为其着色甲a的试剂系统，所述分析物的存在和/ 正在寻求集中。 该方法包括将四唑鎓盐从其在有机溶剂中的溶液中施加到基质中，并且在干燥之后，将其从已经加入己烷磺酸盐的水溶液作为润湿剂施加到基质中。

公开(公告)号：US07678250B2

公开(公告)日：2010-03-16

申请号：US12017496

申请日：2008-01-22

申请人： Douglas E. Bell ,  Michele Albino

发明人： Douglas E. Bell ,  Michele Albino

IPC分类号： G01N27/327 ,  G01N21/00

CPC分类号： C12Q1/006 ,  Y10T29/53204

摘要： Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at least one coordination complex.

摘要翻译： 对患者样品中血糖浓度的敏感性提高的生物试剂组合物用于测量系统和方法。 试剂组合物包含葡萄糖氧化还原酶，黄素核苷辅酶和介体制剂。 介体制剂包含至少一种电活性有机分子和至少一种配位络合物。

公开(公告)号：US07160251B2

公开(公告)日：2007-01-09

申请号：US10706634

申请日：2003-11-12

申请人： Gary T. Neel ,  Douglas E. Bell ,  T. Philip Wong

发明人： Gary T. Neel ,  Douglas E. Bell ,  T. Philip Wong

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： C12Q1/006 ,  G01N27/3272 ,  Y10T29/49002 ,  Y10T156/12 ,  Y10T436/104998 ,  Y10T436/144444

摘要： A system for measuring a glucose level in a blood sample includes a test strip and a meter. The test strip includes a sample chamber, a working electrode, a counter electrode, fill-detect electrodes, and an auto-on conductor. A reagent layer is disposed in the sample chamber. The auto-on conductor causes the meter to wake up and perform a test strip sequence when the test strip is inserted in the meter. The meter uses the working and counter electrodes to initially detect the blood sample in the sample chamber and uses the fill-detect electrodes to check that the blood sample has mixed with the reagent layer. The meter applies an assay voltage between the working and counter electrodes and measures the resulting current. The meter calculates the glucose level based on the measured current and calibration data saved in memory from a removable data storage device associated with the test strip.

公开(公告)号：US07049130B2

公开(公告)日：2006-05-23

申请号：US11084007

申请日：2005-03-21

申请人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

发明人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

IPC分类号： C12M3/00

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/827

摘要： An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing. The improved test strip comprises no more than two operative layers and: (a) a reaction membrane containing a reagent capable of reacting with the analyte of interest to produce a measurable change in said membrane; (b) an upper support layer defining a sample receiving port for receiving the fluid sample thereat; (c) one or more structures for directing the sample containing the analyte of interest through at least a portion of said reaction membrane; and (d) a lower support layer having a reaction viewing port in vertical alignment with said membrane for displaying said measurable change, said lower support being associated with said upper support to secure said reaction membrane in said test strip.

公开(公告)号：US20100227355A1

公开(公告)日：2010-09-09

申请号：US12724280

申请日：2010-03-15

申请人： Douglas E. Bell ,  Michele Albino

发明人： Douglas E. Bell ,  Michele Albino

IPC分类号： C12Q1/26 ,  C12Q1/32

CPC分类号： C12Q1/006 ,  Y10T29/53204

摘要： Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at least one coordination complex.

摘要翻译： 对患者样品中血糖浓度的敏感性提高的生物试剂组合物用于测量系统和方法。 试剂组合物包含葡萄糖氧化还原酶，黄素核苷辅酶和介体制剂。 介体制剂包含至少一种电活性有机分子和至少一种配位络合物。

公开(公告)号：US20090170188A1

公开(公告)日：2009-07-02

申请号：US12398749

申请日：2009-03-05

申请人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

发明人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

IPC分类号： G01N31/22 ,  C12M1/00

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/827

摘要： An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing. The improved test strip comprises no more than two operative layers and: (a) a reaction membrane containing a reagent capable of reacting with the analyte of interest to produce a measurable change in said membrane; (b) an upper support layer defining a sample receiving port for receiving the fluid sample thereat; (c) one or more structures for directing the sample containing the analyte of interest through at least a portion of said reaction membrane; and (d) a lower support layer having a reaction viewing port in vertical alignment with said membrane for displaying said measurable change, said lower support being associated with said upper support to secure said reaction membrane in said test strip.

摘要翻译： 一种用于接收诸如全血的异质流体的改进的多层诊断卫生测试条，用于通过促进对应于分析物的量的条带中的颜色变化来测试流体中可疑分析物的存在和/或量的存在和/或量 在流体中，其中测试条包括流体体积控制坝，以防止来自条带的流体溢出，以及促进终点测试的化学试剂溶液。 改进的测试条包含不超过两个操作层，并且：（a）含有能够与感兴趣的分析物反应以产生所述膜中可测量的变化的试剂的反应膜; （b）限定用于在其上接收流体样品的样品接收端口的上支撑层; （c）用于通过所述反应膜的至少一部分引导含有目标分析物的样品的一种或多种结构; 和（d）下支撑层，其具有与所述膜垂直对准的反应观察端口，用于显示所述可测量的变化，所述下支撑件与所述上支撑件相关联，以将所述反应膜固定在所述测试条中。

公开(公告)号：US20080112852A1

公开(公告)日：2008-05-15

申请号：US11930906

申请日：2007-10-31

申请人： Gary T. Neel ,  Douglas E. Bell

发明人： Gary T. Neel ,  Douglas E. Bell

IPC分类号： G01N27/00

CPC分类号： G01N33/48771

摘要： A test strip for measuring an analyte level in a fluid sample includes a sample chamber configured to receive the fluid sample; a plurality of electrodes configured to produce at least one current measurement related to the analyte level in the fluid sample; and at least one information-providing connector having an intrinsic electrical property representative of at least one test strip calibration parameter specific to the test strip. A system for measuring an analyte level in a fluid sample may include such a test strip along with a data acquisition system controlled by a processor and configured to measure an intrinsic electrical property of the information-providing connector and to obtain at least one test strip calibration parameter corresponding to the test strip from at least one predetermined location in a memory based on the intrinsic electrical property.

摘要翻译： 用于测量流体样品中的分析物水平的测试条包括被配置为接收流体样品的样品室; 多个电极，被配置为产生与流体样品中的分析物水平相关的至少一个电流测量; 以及至少一个信息提供连接器，其具有代表测试条特有的至少一个测试条校准参数的本征电特性。 用于测量流体样品中的分析物水平的系统可以包括这样的测试条以及由处理器控制并被配置为测量信息提供连接器的本征电特性并且获得至少一个测试条校准的数据采集系统 参数对应于来自存储器中的至少一个预定位置的测试条。

公开(公告)号：US06991940B2

公开(公告)日：2006-01-31

申请号：US09984948

申请日：2001-10-31

申请人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

发明人： Patrick Carroll ,  Jon Schneider ,  Douglas E. Bell

IPC分类号： G01N33/558

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/827

摘要： An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing. The improved test strip comprises no more than two operative layers and: (a) a reaction membrane containing a reagent capable of reacting with the analyte of interest to produce a measurable change in said membrane; (b) an upper support layer defining a sample receiving port for receiving the fluid sample thereat; (c) one or more structures for directing the sample containing the analyte of interest through at least a portion of said reaction membrane; and (d) a lower support layer having a reaction viewing port in vertical alignment with said membrane for displaying said measurable change, said lower support being associated with said upper support to secure said reaction membrane in said test strip.

公开(公告)号：US06964871B2

公开(公告)日：2005-11-15

申请号：US10764972

申请日：2004-01-26

申请人： Douglas E. Bell ,  Gary T. Neel ,  T. Philip Wong

发明人： Douglas E. Bell ,  Gary T. Neel ,  T. Philip Wong

IPC分类号： A61K20060101 ,  C12Q1/00 ,  G01N27/00 ,  G01N27/26 ,  G01N33/00 ,  G01N33/487 ,  G01N33/543 ,  G01N33/66

CPC分类号： C12Q1/006 ,  G01N27/3272 ,  G01N33/54373 ,  G01N33/66 ,  Y10T29/49002 ,  Y10T436/104998 ,  Y10T436/144444

摘要： A system for measuring a glucose level in a blood sample includes a test strip and a meter. The test strip includes a sample chamber or other testing zone, a working electrode, a counter electrode, fill-detect electrodes, and an auto-on conductor. A reagent layer is disposed in the testing zone. The auto-on conductor causes the meter to wake up and perform a test strip sequence when the test strip is inserted in the meter. The meter uses the working and counter electrodes to initially detect the blood sample in the sample chamber and uses the fill-detect electrodes to check that the blood sample has mixed with the reagent layer. The meter applies an assay voltage between the working and counter electrodes and measures the resulting current. The meter calculates the glucose level based on the measured current and calibration data saved in memory from a removable data storage device associated with the test strip.

摘要翻译： 用于测量血液样品中的葡萄糖水平的系统包括测试条和米。 测试条包括样品室或其他测试区，工作电极，对电极，填充检测电极和自动导体。 试剂层设置在测试区域中。 当测试条插入仪表时，自动导体导致仪表醒来并执行测试条序列。 仪表使用工作电极和对电极初始检测样品室中的血液样品，并使用填充检测电极检查血液样品是否与试剂层混合。 仪表在工作电极和对电极之间施加测定电压并测量所得电流。 仪表根据与测试条相关联的可移动数据存储设备中保存在存储器中的测量电流和校准数据计算葡萄糖水平。