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    Remedy/preventive for vascular disorders and hypertension and method of screening the same
    4.
    发明申请
    Remedy/preventive for vascular disorders and hypertension and method of screening the same 有权
    补救/预防血管疾病和高血压及筛查方法相同

    公开(公告)号：US20090312415A1

    公开(公告)日：2009-12-17

    申请号：US10579173

    申请日：2004-11-11

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai ,  Richard J. Johnson ,  Karen Leigh Price

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai ,  Richard J. Johnson ,  Karen Leigh Price

    IPC分类号： A61K31/343 ,  C12Q1/62 ,  C12Q1/02 ,  C12Q1/68 ,  A61K31/18

    CPC分类号： G01N33/5061 ,  A61K31/00 ,  G01N33/5008 ,  G01N2500/00 ,  Y10T436/103332

    摘要： It is intended to clarify a transportation system participating in the uric acid uptake in vascular smooth muscle cells (VSMCs) and provide a novel remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of a drug participating in this transportation system. It is also intended to provide a novel screening system for a remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of such a transportation system. Namely, a medicinal composition for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises a drug having an effect of inhibiting the uric acid uptake by a uric acid transporter URAT1 and a pharmaceutically acceptable carrier; and a method of screening a substance efficacious for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises using a cell line expressing URAT1 in the presence or absence of a test compound and assaying the uric acid uptake level, cell proliferation ability or the amount of a monocyte chemotactic factor produced by the cells.

    摘要翻译： 旨在澄清参与血管平滑肌细胞（VSMC）中尿酸摄取的运输系统，并提供新的治疗方法，血管疾病，高血压和肾脏疾病的预防或治疗剂，使用药物参与 这个运输系统。 还旨在提供一种用于治疗的新型筛选系统，用于血管疾病，高血压和肾脏疾病的预防或治疗剂，其使用这种运输系统。 即，用于治疗，预防或治疗血管疾病，高血压和肾脏疾病的药物组合物，其包含具有抑制尿酸转运蛋白URAT1和药学上可接受的载体的尿酸摄取的作用的药物; 以及筛选对于治疗，预防或治疗血管疾病，高血压和肾脏疾病有效的物质的方法，其包括在存在或不存在测试化合物的情况下使用表达URAT1的细胞系，并测定尿酸摄取水平，细胞增殖能力或 由细胞产生的单核细胞趋化因子的量。

    Quality control material for reagentless measurement of analytes
    5.
    发明申请
    Quality control material for reagentless measurement of analytes 有权
    用于试剂分析物测量的质量控制材料

    公开(公告)号：US20040121476A1

    公开(公告)日：2004-06-24

    申请号：US10721253

    申请日：2003-11-26

    发明人： James Samsoondar

    IPC分类号： G01N033/20

    CPC分类号： G01N33/72 ,  G01N33/96 ,  G01N2496/15 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/103332 ,  Y10T436/105831 ,  Y10T436/106664

    摘要： The present invention provides a method of monitoring calibration of a spectrophotometric apparatus that comprises one or more calibration algorithms for one or more analytes. This method comprises measuring absorbance of a quality control material with the apparatus to obtain a measurement, where the quality control material exhibits an absorbance spectra characterized as having a negative slope for a continuous spectral segment from about 5 nm to about 200 nm in length, and where the spectral segment includes a principal calibration wavelength for the one or more analytes. The method then involves calculating one or more concentration values from the measurement using the one or more calibration algorithms, followed by comparing the one or more concentration values with an assigned value given to the quality control material for each of the one or more analytes, and determining if there is a violation of a pre-established quality control rule. In this way one or more calibration algorithms of the apparatus may be monitored. A reagentless method for determining the concentration of one or more analytes in a sample in a spectrophotometric apparatus comprising at least one primary calibration algorithm is also disclosed. The present invention also provides to a method for selecting one or more substances as a quality control material for monitoring at least one primary calibration algorithm on a spectrophotometric apparatus. The present invention includes a quality control material for mimicking two or more analytes comprising, one or more substances having a combined absorption spectrum exhibiting a negative slope for a continuous spectral segment from about 5 nm to 200 nm in length, in a portion of an absorption spectrum, including one or more principal calibration wavelengths, for the two or more analytes.

    摘要翻译： 本发明提供了一种监测分光光度仪器的校准方法，该方法包括一种或多种用于一种或多种分析物的校准算法。 该方法包括用所述装置测量质量控制材料的吸光度以获得测量，其中质量控制材料表现出对于长度为约5nm至约200nm的连续光谱段具有负斜率的吸收光谱，以及 其中光谱段包括一个或多个分析物的主校准波长。 该方法然后包括使用一个或多个校准算法从测量中计算一个或多个浓度值，然后将一个或多个浓度值与为一种或多种分析物中的每一种给予质量控制材料的指定值进行比较，以及 确定是否违反了预先确定的质量控制规则。 以这种方式，可以监视装置的一个或多个校准算法。 还公开了一种用于在包括至少一个主要校准算法的分光光度计装置中测定样品中一种或多种分析物的浓度的无试剂方法。 本发明还提供了一种用于选择一种或多种物质作为质量控制材料的方法，用于在分光光度计装置上监测至少一种主要校准算法。 本发明包括用于模拟两种或更多种分析物的质量控制材料，所述质量控制材料包含一种或多种物质，所述物质具有在吸收的一部分中长度为约5nm至200nm的连续光谱段呈现负斜率的组合吸收光谱 包括一个或多个主要校准波长，用于两种或多种分析物。

    Micromachined fluid analysis device and method
    6.
    发明申请
    Micromachined fluid analysis device and method 有权
    微加工液分析装置及方法

    公开(公告)号：US20030121313A1

    公开(公告)日：2003-07-03

    申请号：US10065578

    申请日：2002-10-31

    发明人： Douglas Ray Sparks

    IPC分类号： G01N015/08

    CPC分类号： G01N15/0656 ,  Y10T436/103332 ,  Y10T436/104998 ,  Y10T436/105831 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A method and device for performing fluid analysis by separating cells and/or particles from a fluid, such as a biological, vehicular or industrial fluid. The device is a micromachined filtering device comprising a substrate with through-thickness vias having approximately equal diameters that prevent passage through the substrate of a first material while permitting passage through the substrate of other materials having diametrical dimensions less than the diameter of the vias. Electrodes are located on a surface of the substrate between vias so that as the first material collects at the surface of the substrate, the electrodes become electrically connected to produce an output signal in some proportion to the amount of the first material collected. The device can incorporate multiple micromachined substrates, yielding an analysis system that produces an electrical output for each of a number of properties or parameters.

    摘要翻译： 一种用于通过从诸如生物，车辆或工业流体的流体分离细胞和/或颗粒来进行流体分析的方法和装置。 该装置是一种微加工过滤装置，其包括具有大致相同直径的贯穿厚度通孔的基板，该通孔防止通过第一材料的基板，同时允许通过具有小于通孔直径的直径尺寸的其他材料的基板。 电极位于通孔之间的基板的表面上，使得当第一材料收集在基板的表面时，电极电连接以产生与所收集的第一材料的量成比例的输出信号。 该装置可以并入多个微加工基板，产生分析系统，其为多个特性或参数中的每一个产生电输出。

    Assay method for biological components
    8.
    发明授权
    Assay method for biological components 失效
    生物成分的测定方法

    公开(公告)号：US5559003A

    公开(公告)日：1996-09-24

    申请号：US348870

    申请日：1994-11-29

    申请人： Sumi Kawahara ,  Toshikatsu Abe ,  Kenji Hosoi

    发明人： Sumi Kawahara ,  Toshikatsu Abe ,  Kenji Hosoi

    IPC分类号： C12Q1/28 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/48

    CPC分类号： C12Q1/28 ,  C12Q2326/96 ,  Y10T436/103332 ,  Y10T436/104165 ,  Y10T436/104998

    摘要： The method is directed to assaying for biological components in a sample comprising step (A) generating an oxidase substrate in the presence of an amphoteric surfactant and in the absence of ferrocyanide; (B) initially generating hydrogen peroxide through said oxidase reaction on said substrate of oxidase with subsequent detection of the generated hydrogen peroxide using peroxidase and a color developer capable of being oxidized in the presence of amphoteric surfactant and ferrocyanide; and (C) correlating the amount of color developed to the amount of biological components in the biological sample. Even when the biological component to be detected is present in a very small amount, the interference of bilirubin can be eliminated in assays of biological components in which peroxidase generated from an enzymatic reaction is detected using peroxidase and a color developer capable of being oxidized.

    摘要翻译： 该方法用于测定包含在两性表面活性剂存在下和在不存在亚铁氰化物的情况下产生氧化酶底物的步骤（A）的样品中的生物组分; （B）最初通过所述氧化酶反应在所述氧化酶底物上产生过氧化氢，随后使用过氧化物酶检测所产生的过氧化氢和能够在两性表面活性剂和亚铁氰化物存在下被氧化的显色剂; 和（C）将生成的生物成分的颜色量与生物样品的生成成分的量相关联。 即使要检测的生物成分以非常小的量存在，也可以在使用过氧化物酶和能够被氧化的彩色显影剂检测由酶反应产生的过氧化物酶的生物成分的测定中，可以消除胆红素的干扰。