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公开(公告)号:US20050107364A1
公开(公告)日:2005-05-19
申请号:US10925072
申请日:2004-08-24
申请人: Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
发明人: Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
IPC分类号: A61K31/549 , C07D285/26
CPC分类号: C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译: 具有下式的化合物是丙型肝炎(HCV)聚合酶抑制剂。 还公开了用于抑制丙型肝炎(HCV)聚合酶,制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号:US20070197558A1
公开(公告)日:2007-08-23
申请号:US11613825
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , C07D498/02 , C07D487/02
CPC分类号: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US20070232627A1
公开(公告)日:2007-10-04
申请号:US11613810
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20070232645A1
公开(公告)日:2007-10-04
申请号:US11613836
申请日:2006-12-20
申请人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
发明人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
IPC分类号: A61K31/4375 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20060264476A1
公开(公告)日:2006-11-23
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/4439 , C07D403/02
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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