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公开(公告)号:US20050107364A1
公开(公告)日:2005-05-19
申请号:US10925072
申请日:2004-08-24
申请人: Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
发明人: Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
IPC分类号: A61K31/549 , C07D285/26
CPC分类号: C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译: 具有下式的化合物是丙型肝炎(HCV)聚合酶抑制剂。 还公开了用于抑制丙型肝炎(HCV)聚合酶,制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号:US20050131042A1
公开(公告)日:2005-06-16
申请号:US10733915
申请日:2003-12-11
申请人: Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
发明人: Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
IPC分类号: A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
CPC分类号: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号:US20060287300A1
公开(公告)日:2006-12-21
申请号:US11363377
申请日:2006-02-27
申请人: Larry Klein , Peggy Huang , John Randolph , Douglas Hutchinson , Ming Yeung , Charles Flentge
发明人: Larry Klein , Peggy Huang , John Randolph , Douglas Hutchinson , Ming Yeung , Charles Flentge
IPC分类号: A61K31/549 , C07D285/22
CPC分类号: C07D471/04 , C07D285/24 , C07D285/30 , C07D417/12
摘要: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
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公开(公告)号:US20050159469A1
公开(公告)日:2005-07-21
申请号:US11010177
申请日:2004-12-10
申请人: John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
发明人: John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
IPC分类号: A61K31/4166 , A61K31/4178 , C07C243/24 , C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D43/02
CPC分类号: C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号:US20050148623A1
公开(公告)日:2005-07-07
申请号:US11008713
申请日:2004-12-09
申请人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein , Ming Yeung , John Randolph , Xiu Wang , Su Yu
发明人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein , Ming Yeung , John Randolph , Xiu Wang , Su Yu
IPC分类号: A61K31/4439 , A61K31/4745 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07D498/02 , C07F9/58 , C07F9/655 , C07F9/6558 , C07K5/02 , C07D43/02
CPC分类号: C07D213/56 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/444 , A61K45/06 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07F9/58 , C07F9/65515 , C07F9/65583 , C07K5/0207
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号:US20120172291A1
公开(公告)日:2012-07-05
申请号:US13339440
申请日:2011-12-29
申请人: Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
发明人: Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
CPC分类号: C07K5/02 , A61K38/00 , C07K5/0804 , C07K5/0827
摘要: The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译: 本发明涉及新的氟化大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐,酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号:US08937041B2
公开(公告)日:2015-01-20
申请号:US13339440
申请日:2011-12-29
申请人: Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
发明人: Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
CPC分类号: C07K5/02 , A61K38/00 , C07K5/0804 , C07K5/0827
摘要: The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译: 本发明涉及新的氟化大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐,酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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