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公开(公告)号：US20070087047A1
公开(公告)日：2007-04-19
申请号：US11633129
申请日：2006-12-01
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
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公开(公告)号：US20060159736A1
公开(公告)日：2006-07-20
申请号：US11267076
申请日：2005-11-04
申请人： Samuel Zalipsky , Francis Martin
发明人： Samuel Zalipsky , Francis Martin
IPC分类号： A61K31/7024 , A61K31/69 , A61K9/127
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K31/69 , A61K31/7024 , A61K47/10
摘要： A liposome composition comprised of liposomes having the peptide boronic acid proteasome inhibitor compound bortezomib entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.
摘要翻译： 描述了脂质体组合物，其包含被脂质体包埋的具有肽硼酸蛋白酶体抑制剂化合物硼替佐米的脂质体。 在与脂质体包被的多元醇相互作用后，硼酸化合物以硼酸酯的形式包埋在脂质体中。 在一个实施方案中，脂质体具有亲水性聚合物链的外涂层，并且用于治疗受试者中的实体瘤。
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公开(公告)号：US20050136064A1
公开(公告)日：2005-06-23
申请号：US11049848
申请日：2005-02-02
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K51/12 , A61K39/395 , C07K16/46 , C12N9/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
摘要翻译： 描述了用于制备对目标细胞敏化的治疗性脂质体组合物的试剂。 试剂包括由预先形成的脂质体组成的脂质体组合物，其具有包埋的治疗剂和由脂质，亲水性聚合物和靶向配体组成的多种靶向缀合物。 通过将脂质体组合物与所选择的缀合物孵育来形成治疗性靶细胞致敏脂质体组合物。
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公开(公告)号：US20060153907A1
公开(公告)日：2006-07-13
申请号：US11267794
申请日：2005-11-04
申请人： Samuel Zalipsky , Francis Martin
发明人： Samuel Zalipsky , Francis Martin
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K31/69 , A61K31/7024 , A61K47/10
摘要： A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.
摘要翻译： 描述了包含脂质体中包含肽硼酸蛋白酶体抑制剂化合物的脂质体的脂质体组合物。 在与脂质体包被的多元醇相互作用后，硼酸化合物以硼酸酯的形式包埋在脂质体中。 在一个实施方案中，脂质体具有亲水性聚合物链的外涂层，并且用于治疗受试者的恶性肿瘤。
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公开(公告)号：US20060246126A1
公开(公告)日：2006-11-02
申请号：US11479437
申请日：2006-06-30
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K39/395 , A61K9/127 , C07K16/46
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US20050169980A1
公开(公告)日：2005-08-04
申请号：US11050012
申请日：2005-02-02
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K51/12 , A61K39/395
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US20050261175A1
公开(公告)日：2005-11-24
申请号：US10353783
申请日：2003-01-28
CPC分类号： C07K16/22
摘要： Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
摘要翻译： 公开了新型干细胞因子，编码它们的寡核苷酸和生产方法。 还公开了治疗涉及血细胞的疾病的药物组合物和方法。
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8.发明申请Apparatus and method for electron beam irradiation having improved dose uniformity ratio 失效具有改善的剂量均匀性比的电子束照射的装置和方法公开(公告)号：US20050098740A1
公开(公告)日：2005-05-12
申请号：US10902394
申请日：2004-07-28
CPC分类号： A61L2/087 , A61L2202/23 , B65B55/08 , B65B55/16
摘要： The present invention is related to an apparatus and method for irradiating a product package, comprising a radiation source directing a radiation beam along a beam direction towards said product package, conveying means for transporting said product package past said radiation source along a transport path, and reflecting means located on at least one side of the plane formed by said beam direction and said transport path. By adjusting the distance and angle of the reflecting means to the conveyor and beam, and improved dose uniformity ratio is obtained.
摘要翻译： 本发明涉及用于照射产品包装的装置和方法，该装置和方法包括将辐射束沿着波束方向引向所述产品包装的辐射源，用于沿着传送路径传送所述产品包装经过所述辐射源的传送装置，以及 反射装置位于由所述光束方向和所述输送路径形成的平面的至少一侧上。 通过调整反射装置与传送带和光束的距离和角度，并获得改进的剂量均匀性比。
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9.发明申请Molecular Method for the Identification of Mating Type Genes of Truffles Species 审中-公开用于鉴定松露种交配型基因的分子方法公开(公告)号：US20130224741A1
公开(公告)日：2013-08-29
申请号：US13820718
申请日：2011-09-07
申请人： Francis Martin , Claude Murat-Furminieux , Francesco Paolocci , Andrea Rubini , Claudia Riccioni , Beatrice Belfiori , Sergio Arcioni
发明人： Francis Martin , Claude Murat-Furminieux , Francesco Paolocci , Andrea Rubini , Claudia Riccioni , Beatrice Belfiori , Sergio Arcioni
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6879 , C12Q1/6895 , C12Q2600/16
摘要： The invention concerns a method for determining the Tuber species and fertility of a truffle sample, said method comprising: - identifying whether said truffle sample comprises a first nucleotide sequence associated with a first mating type idiomorph (MAT1-2); and - identifying whether said truffle sample comprises a second nucleotide sequence associated with a second mating type idiomorph (MAT1-1); the fertility of said truffle sample requiring the presence of both the first and the second nucleotide sequences.
摘要翻译： 本发明涉及一种用于确定松露样品的块茎种类和生育力的方法，所述方法包括： - 鉴定所述松露样品是否包含与第一交配型成熟物（MAT1-2）相关的第一核苷酸序列; 以及 - 鉴定所述松露样品是否包含与第二交配型成熟物（MAT1-1）相关联的第二核苷酸序列; 所述松露样品的生育力需要存在第一和第二核苷酸序列。
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公开(公告)号：US20070071714A1
公开(公告)日：2007-03-29
申请号：US11517619
申请日：2006-09-07
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/475 , C12N5/08
CPC分类号： C07K16/22
摘要： Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
摘要翻译： 公开了新型干细胞因子，编码它们的寡核苷酸和生产方法。 还公开了治疗涉及血细胞的疾病的药物组合物和方法。
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