公开(公告)号：US10085940B2

公开(公告)日：2018-10-02

申请号：US14232332

申请日：2012-07-12

申请人： Alberto A. Gabizon ,  Yechezkel Barenholz ,  Hilary Shmeeda ,  John Maher ,  Ana Catarina Parente Pereira

发明人： Alberto A. Gabizon ,  Yechezkel Barenholz ,  Hilary Shmeeda ,  John Maher ,  Ana Catarina Parente Pereira

IPC分类号： A61K31/704 ,  A61K9/127 ,  A61K31/663 ,  A61K38/20 ,  A61K45/06 ,  A61K35/15 ,  A61K35/17 ,  A61K47/55 ,  A61K47/69 ,  A61K39/00

摘要： The present disclosure provides liposomes comprising a membrane and an intraliposomal aqueous water phase, the membrane comprising at least one liposome forming lipid and the intraliposomal aqueous water phase comprises a salt of a bisphosphonate together with an amphipathic weak base agent (PLAD). An example of a liposome is one comprising co encapsulated in the intraliposomal aqueous water phase N-containing bisphosphonate, such as alendronate, and an anthracycline such as doxorubicin which was shown to increase survival as compared to Doxil or to administrations of liposomal alendronate (PLA) and Doxil (separate liposomes). Such liposomes may carry a targeting moiety exposed at the liposome's outer surface, for example, conjugate of folic acid as a targeting moiety to folate receptor (FT-PLAD). Also provided by the present disclosure is a method of preparing the liposomes and methods of use of the liposomes, at times, in combination with additional active ingredients, such as γδ T-cells.

公开(公告)号：US20050267729A1

公开(公告)日：2005-12-01

申请号：US11141599

申请日：2005-05-31

申请人： Mitchell Poplack ,  John Maher

发明人： Mitchell Poplack ,  John Maher

IPC分类号： G06F9/455 ,  G06F17/50

CPC分类号： G06F17/5027

摘要： A target interface system for interfacing selected components of a communication system and methods for manufacturing and using same. The target interface system includes target interface logic that is distributed among a plurality of reconfigurable logic devices. Being coupled via a serial link, the reconfigurable logic devices each have an input connection for receiving incoming data packets and an output connection for providing outgoing data packets. The serial link couples the input and output connections of successive reconfigurable logic devices to form a dataring structure for distributing the data packets among the reconfigurable logic devices. Thereby, the dataring structure maintains data synchronization among the reconfigurable logic devices such that the distribution of the target interface logic among the reconfigurable logic devices is transparent to software.

摘要翻译： 用于连接通信系统的选定组件的目标接口系统及其制造和使用方法。 目标接口系统包括分布在多个可重新配置的逻辑设备中的目标接口逻辑。 通过串行链路耦合，可重配置逻辑器件每个都具有用于接收输入数据分组的输入连接和用于提供输出数据分组的输出连接。 串行链路将连续的可重构逻辑设备的输入和输出连接耦合以形成用于在可重新配置的逻辑设备之间分配数据分组的数据结构。 因此，数据结构维持可重构逻辑设备之间的数据同步，使得可重构逻辑设备中的目标接口逻辑的分布对于软件是透明的。

公开(公告)号：US20050267728A1

公开(公告)日：2005-12-01

申请号：US11140722

申请日：2005-05-31

申请人： John Maher ,  Mitchell Poplack

发明人： John Maher ,  Mitchell Poplack

IPC分类号： G06F9/455 ,  G06F13/38

CPC分类号： G06F13/387

摘要： A target interface system for interfacing selected components of a communication system and methods for manufacturing and using same. Being reconfigurable to support an extensive range of conventional input/output technologies, the target interface system downloads a selected image associated with a desired input/output technology prior to runtime. The selected image identifies an appropriate output driver supply voltage, and any auxiliary voltages are controlled as functions of the output driver supply voltage to limit voltage inconsistencies. Defaulting each voltage to its least dangerous state when unprogrammed, the target interface system subsequently monitors the voltages, disabling the input/output connections if a problem is detected. The target interface system likewise detects when a selected system component is absent, unpowered, and/or wrongly powered and provides contention detection. Thereby, the target interface system can facilitate communication among the system components while inhibiting damage to the target interface system and/or the system components.

摘要翻译： 用于连接通信系统的选定组件的目标接口系统及其制造和使用方法。 可重新配置以支持广泛的常规输入/输出技术，目标接口系统在运行之前下载与所需输入/输出技术相关联的所选图像。 所选择的图像识别适当的输出驱动器电源电压，并且任何辅助电压被控制为输出驱动器电源电压的功能，以限制电压不一致。 当未编程时，将每个电压默认为最低危险状态，目标接口系统随后监控电压，如果检测到问题，则禁用输入/输出连接。 目标接口系统同样检测所选择的系统组件何时不存在，无电源和/或错误地供电并提供争用检测。 因此，目标接口系统可以促进系统组件之间的通信，同时抑制对目标接口系统和/或系统组件的损坏。

公开(公告)号：US20230139449A1

公开(公告)日：2023-05-04

申请号：US17972584

申请日：2022-10-24

申请人： David Pozgay ,  Milbert O. La Valle ,  Lucindo Sofronio DL. Valenciano ,  Devin Hughes ,  Slavisa Dacic ,  John Maher ,  Weston Van Wembeke

发明人： David Pozgay ,  Milbert O. La Valle ,  Lucindo Sofronio DL. Valenciano ,  Devin Hughes ,  Slavisa Dacic ,  John Maher ,  Weston Van Wembeke

IPC分类号： E04G1/30 ,  E04G1/34 ,  E04G5/08

摘要： A work platform includes a plank which telescopes to a desired width. The work platform includes a first leg assembly rotatably attached adjacent to a first end of the plank. The work platform includes a second leg assembly rotatably attached adjacent to a second end of the plank. The work platform includes a first linkage attached to a first leg of the first leg assembly. The first linkage may be a first hook or a first strap assembly for securing the work platform to a first support structure. A method for using a work platform. A method for producing a work platform.

公开(公告)号：US07446190B2

公开(公告)日：2008-11-04

申请号：US10448256

申请日：2003-05-28

申请人： Michel Sadelain ,  Renier Brentjens ,  John Maher

发明人： Michel Sadelain ,  Renier Brentjens ,  John Maher

IPC分类号： C07H21/04

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/3069 ,  C07K2319/00

摘要： Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 ζ-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.

摘要翻译： 提供嵌合T细胞受体（TCR），其在单个嵌合物种中结合CD3zeta链的细胞内结构域，来自共刺激蛋白如CD28的信号传导区域，以及与选定靶标特异性相互作用的结合元件。 当表达时，例如来自待治疗个体的T淋巴细胞与所选择的靶标相关的病症，T细胞免疫应答在个体中被刺激到靶细胞。 嵌合TCR能够提供来自单个分子的活化和共刺激信号，以更有效地指导针对所选择的靶标和T淋巴细胞增殖的T淋巴细胞细胞毒性。

公开(公告)号：US20050278163A1

公开(公告)日：2005-12-15

申请号：US11141141

申请日：2005-05-31

申请人： Mitchell Poplack ,  John Maher

发明人： Mitchell Poplack ,  John Maher

IPC分类号： G06F9/455

CPC分类号： G06F11/261

摘要： A signal conversion system for interfacing selected components of a communication system and methods for manufacturing and using same. The signal conversion system converts selected logic signals from one system component into a pair of differential logic signals and provides the pair of differential logic signals to a second system component, resolving any logical and/or temporal artifacts. While one or more of the selected logic signals change signal state, the signal conversion system maintains the pair of differential logic signals in a first valid combined signal state until the signal state of the selected logic signals corresponds to a second valid combined signal state for the pair of differential logic signals. The signal verification system then updates the pair of differential logic signals to have the second valid combined signal state. The system components thereby can communicate, exchanging differential communication signals while maintaining duty cycle and avoiding signaling glitches.

摘要翻译： 一种用于连接通信系统的选定组件的信号转换系统及其制造和使用方法。 信号转换系统将所选逻辑信号从一个系统组件转换成一对差分逻辑信号，并将一对差分逻辑信号提供给第二系统组件，以解决任何逻辑和/或时间假象。 当所选逻辑信号中的一个或多个改变信号状态时，信号转换系统将该对差分逻辑信号维持在第一有效组合信号状态，直到所选逻辑信号的信号状态对应于第二有效组合信号状态 差分逻辑信号对。 信号验证系统然后更新该对差分逻辑信号以具有第二有效组合信号状态。 因此，系统组件可以通信，交换差分通信信号，同时保持占空比并避免信令故障。

公开(公告)号：US10810660B1

公开(公告)日：2020-10-20

申请号：US13612720

申请日：2012-09-12

申请人： Andrew J. Diggdon ,  John Maher ,  Karen Lynne Moore ,  Yon Wing Lee ,  Brian Paul McMahon

发明人： Andrew J. Diggdon ,  John Maher ,  Karen Lynne Moore ,  Yon Wing Lee ,  Brian Paul McMahon

IPC分类号： G06Q40/00 ,  G06Q20/00 ,  G06Q20/08 ,  G06Q20/10

摘要： A computer-implemented data processing system includes a data storage system, and a processor and program logic stored in memory and executable by the processor. The program logic includes logic configured to manage accounts respectively associated with a plurality of users, process transactions for the accounts and store account data related to the accounts in the data storage device, access the account data stored in the storage device and determine projected retirement spending amounts for a user based on account data associated with the user, determine a projected required savings amount based on the projected retirement spending amounts, and establish a connection with one of the users and provide the user with a user interface, the user interface including retirement planning data, the retirement planning data including an indication of the user's progress in accumulating the projected required savings amount.

公开(公告)号：US20110272222A1

公开(公告)日：2011-11-10

申请号：US12776122

申请日：2010-05-07

申请人： Terry L. Heffelfinger ,  Dave Wagner ,  Mark Bonasera ,  Terry Kloster ,  John Maher ,  Hiqmet Celhyka

发明人： Terry L. Heffelfinger ,  Dave Wagner ,  Mark Bonasera ,  Terry Kloster ,  John Maher ,  Hiqmet Celhyka

IPC分类号： F16D65/092 ,  B23P15/18 ,  F16D66/02 ,  F16D65/04 ,  F16D69/02

CPC分类号： F16D65/0037 ,  F16D65/092 ,  F16D2069/002 ,  F16D2069/004 ,  F16D2069/005 ,  F16D2069/0483 ,  F16D2069/0491 ,  F16D2200/0039 ,  Y10T29/49906

摘要： A hybrid brake pad that includes a backing plate and a semi-metallic portion having a central groove. The semi-metallic portion is connected with the backing plate. A first ceramic composite portion is adjacent to the semi-metallic portion, and connecting with the backing plate. A second ceramic composite portion is opposite the first ceramic composite portion, and connecting with the backing plate.

摘要翻译： 一种混合式制动衬块，其包括背板和具有中心槽的半金属部分。 半金属部分与背板连接。 第一陶瓷复合部分与半金属部分相邻，并与背板连接。 第二陶瓷复合部分与第一陶瓷复合部分相对，并与背板连接。

公开(公告)号：US20050154221A1

公开(公告)日：2005-07-14

申请号：US10508805

申请日：2003-04-17

申请人： Zenon Lysenko ,  Bob Maughon ,  Josef Bicerano ,  Kenneth Burdett ,  Christopher Christenson ,  Clark Cummins ,  Marvin Dettloff ,  Alan Schrock ,  P. J. Thomas ,  Richard Varjian ,  Jerry White ,  John Maher

发明人： Zenon Lysenko ,  Bob Maughon ,  Josef Bicerano ,  Kenneth Burdett ,  Christopher Christenson ,  Clark Cummins ,  Marvin Dettloff ,  Alan Schrock ,  P. J. Thomas ,  Richard Varjian ,  Jerry White ,  John Maher

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C6/04 ,  C07C11/02 ,  C07C67/333 ,  C07C67/347 ,  C07C67/475 ,  C07C67/56 ,  C07C69/533 ,  C07C69/58 ,  C07C227/08 ,  C07C227/18 ,  C07C229/08 ,  C07D303/42 ,  C07C51/43

CPC分类号： C07D303/42 ,  C07C67/31 ,  C07C67/333 ,  C07C67/347 ,  C07C67/56 ,  C07C69/533 ,  C07C227/08 ,  C07C227/18 ,  C07C229/08 ,  Y02P20/125 ,  C07C69/716 ,  C07C69/675

摘要： Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poisons, particularly hydroperoxides; metathesis of the feedstock composition with a lower olefin, such as ethylene, to form a reduced chain olefin, preferably, a reduced chain α-olefin, and a reduced chain unsaturated acid or ester, preferably, a reduced chain α,Ω-unsaturated acid or ester. The reduced chain unsaturated acid or ester may be (trans)esterified to form a polyester polyolefin, which may be epoxidized to form a polyester polyepoxide. The reduced chain unsaturated acid or ester may be hydroformylated with reduction to produce an α,Ω-hydroxy acid or α,Ω-hydroxy ester, which may be (trans)esterified with a polyol to form an α,Ωpolyester polyol. Alternatively, the reduced chain unsaturated acid or ester may be hydroformylated with reductive amination to produce an α,Ω-amino acid or α,Ω-amino ester, which may be (trans)esterified to form an α,Ωpolyester polyamine.

摘要翻译： 从含有一种或多种不饱和脂肪酸或不饱和脂肪酸酯的种子油原料组合物制备工业化学品的综合方法，其基本上不含复分解催化剂毒物，特别是氢过氧化物; 原料组合物与低级烯烃如乙烯的复分解以形成还原链烯烃，优选还原链α-烯烃和还原链不饱和酸或酯，优选还原链α，ω-不饱和酸 或酯。 还原链不饱和酸或酯可以（反式）酯化以形成聚酯聚烯烃，其可以被环氧化以形成聚酯多环氧化物。 还原链不饱和酸或酯可以通过还原反应加氢甲酰化以产生α，ω-羟基酸或α，ω-羟基酯，其可以与多元醇反应形成α，ω-聚酯多元醇。 或者，还原链不饱和酸或酯可以通过还原胺化加氢甲酰化以产生α，ω-氨基酸或α，ω-氨基酯，其可以（反式）酯化形成α，ω-聚酯多胺。

公开(公告)号：US5229989A

公开(公告)日：1993-07-20

申请号：US994185

申请日：1992-12-21

申请人： John Maher ,  James Erricco ,  Theodore Bloomstein

发明人： John Maher ,  James Erricco ,  Theodore Bloomstein

IPC分类号： H04W84/08

CPC分类号： H04W84/08

摘要： The present invention discloses a communication system network that comprises a plurality of communication systems and a processing multiplexer. The communication systems, which may be either conventional communication systems and/or trunked communication systems, transmit digitized audio signals and communication system data to the processing multiplexer. Based on signal destination data, which is part of the communication system data, the processing multiplexer processes the digitized signals and routes the resultant signals to the appropriate signal destinations.

摘要翻译： 本发明公开了一种包括多个通信系统和处理多路复用器的通信系统网络。 可以是常规通信系统和/或集群通信系统的通信系统将数字化音频信号和通信系统数据发送到处理多路复用器。 基于作为通信系统数据的一部分的信号目的地数据，处理多路复用器处理数字化信号并将所得信号路由到适当的信号目的地。