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公开(公告)号：US20220098567A1
公开(公告)日：2022-03-31
申请号：US17547689
申请日：2021-12-10
摘要： Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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公开(公告)号：US20200291378A1
公开(公告)日：2020-09-17
申请号：US16650094
申请日：2018-09-25
摘要： Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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公开(公告)号：US11230705B2
公开(公告)日：2022-01-25
申请号：US16650094
申请日：2018-09-25
摘要： Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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公开(公告)号：US20190316158A1
公开(公告)日：2019-10-17
申请号：US16337072
申请日：2016-12-30
发明人： Paresh C. Sanghani , Eric C. Shiue , Scott A. Greenwalt , Prakash Bhosale , Sarah Delaplane , Christopher C. Stowers
摘要： Genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid utilizing genetically modified LeuCD′ enzyme complexes, and microbial organisms including modified LeuCD enzyme complexes are described. The instantly-disclosed genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid, and microbial organisms including modified LeuCD′ enzyme complexes can be particularly useful for producing C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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公开(公告)号：US11236310B2
公开(公告)日：2022-02-01
申请号：US16337072
申请日：2016-12-30
发明人： Paresh C. Sanghani , Eric C. Shiue , Scott A. Greenwalt , Prakash Bhosale , Sarah Delaplane , Christopher C. Stowers
IPC分类号： C12N9/88 , C12P7/04 , C12N9/10 , C12P7/24 , C12P7/40 , C12N9/04 , C12P7/44 , C12N15/52 , C12N9/02 , C12P5/02
摘要： Genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid utilizing genetically modified LeuCD′ enzyme complexes, and microbial organisms including modified LeuCD enzyme complexes are described. The instantly-disclosed genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid, and microbial organisms including modified LeuCD′ enzyme complexes can be particularly useful for producing C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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6.发明申请公开(公告)号：US20170369863A1
公开(公告)日：2017-12-28
申请号：US15533390
申请日：2015-12-10
发明人： Paresh C. Sanghani , Christopher C. Stowers , Brandon A. Rodriguez , Eric C. Shiue , Scott A. Greenwalt
IPC分类号： C12N9/88 , C12P7/40 , C12P7/24 , C12P5/02 , C12P7/64 , C12P7/04 , C10L1/02 , C10L1/14 , C10L1/04
CPC分类号： C12N9/88 , C10L1/02 , C10L1/04 , C10L1/14 , C12P5/02 , C12P7/04 , C12P7/24 , C12P7/40 , C12P7/6409 , C12Y401/01043
摘要： Modification of the amino acid sequence of a phenylpyruvate decarboxylase from Azospirillum brasilense produces a novel group of phenylpyruvate decarboxylases with improved specificity to certain substrates, including in particular C7-C11 2-ketoacids such as, for example, 2-ketononanoate and 2-keto-octanoate. This specificity enables effective use of the phenylpyruvate decarboxylase in, for example, an in vivo process wherein 2-ketobutyrate or 2-ketoisovalerate are converted to C7-C11 2-ketoacids, and the novel phenylpyruvate decarboxylase converts the C7-C11 2-ketoacid to a C6-C10 aldehyde having one less carbon than the 2-ketoacid. Ultimately, through contact with additional enzymes, such C6-C10 aldehydes may be converted to, for example, C6-C10 alcohols, C6-C10 carboxylic acids, C6-C10 alkanes, and other derivatives. Use of the novel genetically modified phenylpyruvate de carboxylases may represent a lower cost alternative to non-biobased approaches.
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公开(公告)号：US11898181B2
公开(公告)日：2024-02-13
申请号：US17547689
申请日：2021-12-10
CPC分类号： C12N9/88 , C12P7/42 , C12Y402/01033
摘要： Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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8.发明授权公开(公告)号：US10260060B2
公开(公告)日：2019-04-16
申请号：US15533390
申请日：2015-12-10
发明人： Paresh C. Sanghani , Christopher C. Stowers , Brandon A. Rodriguez , Eric C. Shiue , Scott A. Greenwalt
IPC分类号： C12N9/88 , C12P5/02 , C12P7/04 , C12P7/24 , C12P7/40 , C12P7/64 , C10L1/02 , C10L1/04 , C10L1/14
摘要： Modification of the amino acid sequence of a phenylpyruvate decarboxylase from Azospirillum brasilense produces a novel group of phenylpyruvate decarboxylases with improved specificity to certain substrates, including in particular C7-C11 2-ketoacids such as, for example, 2-ketononanoate and 2-keto-octanoate. This specificity enables effective use of the phenylpyruvate decarboxylase in, for example, an in vivo process wherein 2-ketobutyrate or 2-ketoisovalerate are converted to C7-C11 2-ketoacids, and the novel phenylpyruvate decarboxylase converts the C7-C11 2-ketoacid to a C6-C10 aldehyde having one less carbon than the 2-ketoacid. Ultimately, through contact with additional enzymes, such C6-C10 aldehydes may be converted to, for example, C6-C10 alcohols, C6-C10 carboxylic acids, C6-C10 alkanes, and other derivatives. Use of the novel genetically modified phenylpyruvate decarboxylases may represent a lower cost alternative to non-biobased approaches.
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