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    Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
    8.
    发明授权
    Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy 有权
    用于靶向下调血管发生和抗癌治疗的多核苷酸构建体，药物组合物和方法

    公开(公告)号：US07989427B2

    公开(公告)日：2011-08-02

    申请号：US12222439

    申请日：2008-08-08

    申请人： Dror Harats ,  Shoshana Greenberger ,  Eyal Breitbart

    发明人： Dror Harats ,  Shoshana Greenberger ,  Eyal Breitbart

    IPC分类号： A61K48/00 ,  A61K9/66 ,  C07H21/04 ,  C12N15/00

    CPC分类号： A61K38/191 ,  A61K31/711 ,  A61K38/177 ,  A61K38/1793 ,  A61K48/00 ,  A61K48/0008 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/108 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/85 ,  C12N2840/20

    摘要： A novel nucleic acid construct for down-regulating angiogenesis in a tissue of a subject is provided. The nucleic acid construct includes: (a) a first polynucleotide region encoding a chimeric polypeptide including a ligand binding domain fused to an effector domain of an apoptosis signaling molecule; and (b) a second polynucleotide region encoding a cis acting regulatory element being for directing expression of the chimeric polypeptide in a specific tissue or cell; wherein the ligand binding domain is selected such that it is capable of binding a ligand present in the specific tissue or cell, whereas binding of the ligand to the ligand binding domain activates the effector domain of the apoptosis signaling molecule. Also provided are methods of utilizing this nucleic acid construct for treating diseases characterized by excessive or aberrant neo-vascularization or cell growth.

    摘要翻译： 提供了用于在受试者的组织中下调血管生成的新型核酸构建体。 核酸构建体包括：（a）编码嵌合多肽的第一多核苷酸区域，其包含与凋亡信号分子的效应结构域融合的配体结合结构域; 和（b）编码顺式作用调节元件的第二多核苷酸区域，用于引导嵌合多肽在特定组织或细胞中的表达; 其中选择配体结合结构域使得其能够结合存在于特定组织或细胞中的配体，而配体与配体结合结构域的结合激活凋亡信号分子的效应结构域。 还提供了利用该核酸构建体治疗以过度或异常新血管形成或细胞生长为特征的疾病的方法。