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公开(公告)号：US09561292B1
公开(公告)日：2017-02-07
申请号：US13971822
申请日：2013-08-20
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales , Christopher Khoury
CPC classification number: A61K41/0057 , A61K41/0052 , A61K41/0066 , A61K41/0071 , A61K49/1821 , G01N33/582
Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.
Abstract translation: 提供了一种无分子合成方法，用于制备单分散纳米颗粒。 纳米体系可用于体内或离体处理和成像细胞。 治疗方式包括使用用可光致活化药物修饰的纳米骨，该药物被纳米级的光响应激活以进行电磁刺激; 使用用可热激活的药物修饰的纳米级，该药物通过纳米级的热响应被激活以进行电磁刺激; 以及纳米星本身对电磁刺激的热响应，其可以直接或间接地导致不期望的细胞的死亡。
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公开(公告)号：US20170151331A1
公开(公告)日：2017-06-01
申请号：US15408563
申请日：2017-01-18
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales , Christopher Khoury
CPC classification number: A61K41/0057 , A61K41/0052 , A61K41/0066 , A61K41/0071 , A61K49/1821 , G01N33/582
Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.
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公开(公告)号：US12173355B2
公开(公告)日：2024-12-24
申请号：US16809674
申请日：2020-03-05
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsin-Neng Wang , Andrew Fales
IPC: C12Q1/68 , A61K31/713 , C12Q1/6825
Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.
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公开(公告)号：US20160076086A1
公开(公告)日：2016-03-17
申请号：US14861353
申请日：2015-09-22
Applicant: DUKE UNIVERSITY
Inventor： Tuan Vo-Dinh , Hsin-Neng Wang , Andrew Fales
IPC: C12Q1/68 , A61K9/16 , A61K31/713
CPC classification number: C12Q1/6825 , A61K31/713 , C12Q2525/301 , C12Q2563/137 , C12Q2563/155
Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.
Abstract translation: 提供等离子体激活的纳米探针用于检测目标生物分子，包括核酸，蛋白质和小分子。 可检测的核酸包括RNA，DNA，mRNA，微小RNA和小核苷酸多态性（SNPs）。 纳米探针可用于敏感检测方法，用于诊断包括癌症在内的疾病和病症。 可以使用纳米探针进行复用，使得可以在单个样本中同时检测多个靶。 纳米探针的使用方法包括通过可见的颜色变化的检测。 纳米探针可用于体内治疗受试者中不需要的细胞。
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公开(公告)号：US20200291463A1
公开(公告)日：2020-09-17
申请号：US16809674
申请日：2020-03-05
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsin-Neng Wang , Andrew Fales
IPC: C12Q1/6825 , A61K31/713
Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.
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Patent Agency Ranking
公开(公告)号：US09789154B1
公开(公告)日：2017-10-17
申请号：US13888226
申请日：2013-05-06
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales
CPC classification number: A61K38/02 , A61K41/0066 , A61K41/0071 , A61K47/62 , A61K47/6923 , A61K49/0065
Abstract: Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which may directly or indirectly cause the death of an undesirable cell. Uptake of nanostars by undesirable cells may also aid in detection, by enhancing contrast or otherwise transforming electromagnetic stimulation during imaging.
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公开(公告)号：US20220233628A1
公开(公告)日：2022-07-28
申请号：US17712479
申请日：2022-04-04
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales
Abstract: A plasmonics-active gold nanostar results from the following process: adding citrate stabilized gold seeds to a solution of tetrachloroauric acid (HAuCl4) under acidic conditions; and mixing a silver salt compound and a weak reducing agent simultaneously into the solution of HAuCl4 under conditions such that the plasmonics-active gold nanostar is produced. The plasmonics-active gold nanostar has a size of at least about 30 nm and up to about 80 nm, comprises a plasmon peak in the near-infrared region, comprises an optical label and a bioreceptor, and is a nucleic acid.
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公开(公告)号：US11324797B2
公开(公告)日：2022-05-10
申请号：US15785615
申请日：2017-10-17
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales
Abstract: Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which may directly or indirectly cause the death of an undesirable cell. Uptake of nanostars by undesirable cells may also aid in detection, by enhancing contrast or otherwise transforming electromagnetic stimulation during imaging.
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公开(公告)号：US09987358B2
公开(公告)日：2018-06-05
申请号：US15408563
申请日：2017-01-18
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales , Christopher Khoury
CPC classification number: A61K41/0057 , A61K41/0052 , A61K41/0066 , A61K41/0071 , A61K49/1821 , G01N33/582
Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.
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公开(公告)号：US20180050077A1
公开(公告)日：2018-02-22
申请号：US15785615
申请日：2017-10-17
Applicant: Duke University
Inventor： Tuan Vo-Dinh , Hsiangkuo Yuan , Andrew Fales
CPC classification number: A61K38/02 , A61K41/0066 , A61K41/0071 , A61K47/62 , A61K47/6923 , A61K49/0065
Abstract: Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which may directly or indirectly cause the death of an undesirable cell. Uptake of nanostars by undesirable cells may also aid in detection, by enhancing contrast or otherwise transforming electromagnetic stimulation during imaging.
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