公开(公告)号：US12064533B2

公开(公告)日：2024-08-20

申请号：US18324951

申请日：2023-05-26

申请人： Duke University

发明人： Benjamin J. Wiley ,  Huayu Tong ,  Jiacheng Zhao

IPC分类号： A61L27/48 ,  A61F2/30 ,  A61L27/52

CPC分类号： A61L27/48 ,  A61F2/30756 ,  A61F2/3094 ,  A61L27/52 ,  A61F2002/30024 ,  A61F2002/30471 ,  A61F2002/30761 ,  A61L2400/12 ,  A61L2430/06

摘要： Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.

公开(公告)号：US11701452B2

公开(公告)日：2023-07-18

申请号：US17845881

申请日：2022-06-21

申请人： Duke University

发明人： Benjamin J. Wiley ,  Huayu Tong ,  Jiacheng Zhao

IPC分类号： A61L27/48 ,  A61F2/30 ,  A61L27/52

CPC分类号： A61L27/48 ,  A61F2/3094 ,  A61F2/30756 ,  A61L27/52 ,  A61F2002/30024 ,  A61F2002/30471 ,  A61F2002/30761 ,  A61L2400/12 ,  A61L2430/06

摘要： Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.

公开(公告)号：US11707555B2

公开(公告)日：2023-07-25

申请号：US17365076

申请日：2021-07-01

申请人： Duke University

发明人： Benjamin J. Wiley ,  Huayu Tong ,  Jiacheng Zhao

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L24/02 ,  A61L27/34 ,  A61L27/32 ,  A61L27/36 ,  A61L27/30

CPC分类号： A61L27/52 ,  A61L24/02 ,  A61L27/20 ,  A61L27/306 ,  A61L27/32 ,  A61L27/34 ,  A61L27/3608 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06

摘要： Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.

公开(公告)号：US20220001079A1

公开(公告)日：2022-01-06

申请号：US17365076

申请日：2021-07-01

申请人： Duke University

发明人： Benjamin J. Wiley ,  Huayu Tong ,  Jiacheng Zhao

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L24/02 ,  A61L27/34 ,  A61L27/30 ,  A61L27/32 ,  A61L27/36

摘要： Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.