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    Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts
    1.
    发明授权
    Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts 有权
    通过包封在用烷基铵脂肪酸盐形成的脂质囊泡中来稳定维生素A衍生物

    公开(公告)号：US06183774B2

    公开(公告)日：2001-02-06

    申请号：US09375683

    申请日：1999-08-17

    Applicant: Duncan T. Aust ,  Michael A. Ross ,  James M. Wilmott ,  James A. Hayward

    Inventor： Duncan T. Aust ,  Michael A. Ross ,  James M. Wilmott ,  James A. Hayward

    IPC: A61K9127

    CPC classification number: A61K9/1272

    Abstract: The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.

    Abstract translation: 本发明提供了选自视黄醇，视黄酯以及与烷基铵脂肪酸盐形成的脂质体中的任意组合的维生素A衍生物及其制造方法。 本发明的脂质体可以在预设的触发条件发生时递送维生素A衍生物质。 本发明优选的脂质体是阳离子脂质体。 本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。 包封的维生素A衍生物因此被脂质体稳定。 因此，本发明还提供了一种将维生素A衍生物稳定化在这种脂质体中的方法。 本发明的脂质体用于提供用于治疗皮肤的局部皮肤治疗制剂。

    Sunscreen composition with enhanced SPF and water resistant properties
    2.
    发明授权
    Sunscreen composition with enhanced SPF and water resistant properties 有权
    具有增强SPF和防水性能的防晒组合物

    公开(公告)号：US07175834B2

    公开(公告)日：2007-02-13

    申请号：US11114668

    申请日：2005-04-26

    Applicant: Duncan T. Aust ,  James M. Wilmott ,  James A. Hayward

    Inventor： Duncan T. Aust ,  James M. Wilmott ,  James A. Hayward

    IPC: A61Q17/04 ,  A61Q17/00 ,  A61Q19/00 ,  A61K8/00 ,  A61K8/04

    CPC classification number: A61K8/044 ,  A61K8/73 ,  A61K2800/413 ,  A61Q17/04 ,  B82Y5/00

    Abstract: The present invention relates to a sunscreen formulation which exhibits superior ultraviolet protection and water resistance than prior art sunscreen compositions. The sunscreen formulation comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition comprising a rheological modifying agent and water. The sunscreen formulation is substantially free of surfactants. According to a preferred embodiment, the sunscreen active agent is ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological modifying agent. Another embodiment of the present invention is a method of protecting skin or hair from ultraviolet radiation by applying an effective amount of the sunscreen formulation of the present invention to the skin or hair.

    Abstract translation: 本发明涉及与现有技术的防晒组合物相比表现出优异的紫外线防护性和耐水性的防晒制剂。 防晒制剂包含（a）包含防晒活性剂的分散体和（b）包含流变改性剂和水的基础组合物。 防晒制剂基本上不含表面活性剂。 根据优选的实施方案，防晒活性剂是甲氧基肉桂酸乙基己酯，丁基甲氧基二苯甲酰甲烷或其组合。 防晒制剂优选包含作为流变改性剂的磷酸化淀粉衍生物。 本发明的另一个实施方案是通过将有效量的本发明的防晒制剂施用于皮肤或毛发来保护皮肤或头发免受紫外线辐射的方法。

    Lipid vesicles formed with alkylammonium fatty acid salts
    3.
    发明授权
    Lipid vesicles formed with alkylammonium fatty acid salts 有权
    由烷基铵脂肪酸盐形成的脂质囊泡

    公开(公告)号：US6071535A

    公开(公告)日：2000-06-06

    申请号：US255160

    申请日：1999-02-22

    Applicant: James A. Hayward ,  David C. Watkins ,  Duncan T. Aust

    Inventor： James A. Hayward ,  David C. Watkins ,  Duncan T. Aust

    IPC: A61K9/127 ,  A61K7/00 ,  A61K9/133

    CPC classification number: A61K9/1272 ,  Y10S514/88 ,  Y10S514/881

    Abstract: The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.

    Abstract translation: 本发明提供用烷基铵脂肪酸盐形成的脂质体及其制造方法。 本发明的脂质体可以在预设触发条件发生时传送截留的负载材料或材料。 本发明优选的脂质体是阳离子脂质体。 本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。 本发明的脂质体用于包封疏水和亲水负载材料。 相应形成的脂质体能够在发生触发或控制条件时递送其负载。

    SYSTEM AND METHOD FOR SECURE DOCUMENT PRINTING AND DETECTION
    6.
    发明申请
    SYSTEM AND METHOD FOR SECURE DOCUMENT PRINTING AND DETECTION 有权
    用于安全文件打印和检测的系统和方法

    公开(公告)号：US20090042191A1

    公开(公告)日：2009-02-12

    申请号：US11954044

    申请日：2007-12-11

    Applicant: James A. Hayward ,  Ming-Hwa Liang ,  John Davis

    Inventor： James A. Hayward ,  Ming-Hwa Liang ,  John Davis

    IPC: C12Q1/68 ,  G01N33/00

    CPC classification number: C12Q1/6816 ,  C08K5/09 ,  C09D7/63 ,  C09D11/03 ,  C09D11/38 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T442/2508 ,  C12Q2563/185

    Abstract: A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The method also comprises collecting a sample of either the ink or toner compound and verifying the ink or toner is genuine by detecting the particular nucleic acid material.

    Abstract translation: 描述用于认证和验证正品的物品的方法。 用于认证该项目的方法包括将与特定核酸碱基序列相关联的特定核酸材料施加到墨盒内的墨盒或调色剂外壳内的调色剂化合物中。 该方法还包括收集油墨或调色剂化合物的样品，并通过检测特定的核酸材料来验证油墨或调色剂是真实的。

    Lipid vesicles formed with alkylammonium fatty acid salts
    7.
    发明授权
    Lipid vesicles formed with alkylammonium fatty acid salts 失效
    由烷基铵脂肪酸盐形成的脂质囊泡

    公开(公告)号：US5874105A

    公开(公告)日：1999-02-23

    申请号：US594175

    申请日：1996-01-31

    Applicant: David C. Watkins ,  Thomas J. Vichroski ,  James A. Hayward

    Inventor： David C. Watkins ,  Thomas J. Vichroski ,  James A. Hayward

    IPC: A61K9/127

    CPC classification number: A61K9/1272

    Abstract: A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.

    Abstract translation: 公开了一种用于封装疏水和亲水物质（即“有效载荷”）的脂质体，其能够在发生触发或控制条件时传递其负载。 形成脂质体以稳定地包封特定的活性剂以形成药剂的递送载体。 递送载体的脂质体在特定环境中是稳定的，但是如果从稳定的环境（例如，特定的pH和/或温度和/或离子强度的特征）传递到改变或不稳定的环境，则其变得不稳定或可渗透，由此递送 他们的有效载荷。

    Composition containing protease separate from glycosidase for removing nits in treating lice infestation
    9.
    发明授权
    Composition containing protease separate from glycosidase for removing nits in treating lice infestation 失效
    含有与糖苷酶分离的蛋白质的组合物用于在治疗虱子感染中除去尼丝

    公开(公告)号：US5935572A

    公开(公告)日：1999-08-10

    申请号：US781643

    申请日：1997-01-10

    Applicant: James A. Hayward ,  David C. Watkins

    Inventor： James A. Hayward ,  David C. Watkins

    IPC: A61K38/48 ,  A61K38/54 ,  A61P33/14 ,  A61K38/47 ,  C12N11/02

    CPC classification number: A61K38/47 ,  A01N63/00 ,  A61K38/4873 ,  C12Y302/01014 ,  C12Y302/01017 ,  C12Y304/22002 ,  A61K9/127

    Abstract: A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the protease from hydrolyzing the glycosidase Separation is accomplished by encapsulating either the protease or glycosidase in a lipidic bilayer vesicle while leaving the other outside the vesicle. The protease and glycosidase destroy complex carbohydrate and protein in nit shells, nit embryos and substances secreted by adult lice. In a method of treatment, an infestation site such as hair is treated with a pediculoside and then with the composition containing a protease and glycosidase, and nits are removed such as by washing.

    Abstract translation: 提供了含有蛋白酶和糖苷酶的组合物，用于在治疗虱子感染中除去尼丝。 将蛋白酶和糖苷酶彼此分离，以防止蛋白酶水解糖苷酶。通过将蛋白酶或糖苷酶包封在脂质双层囊泡中，同时将另一个留在囊泡外部来实现分离。 蛋白酶和糖苷酶破坏了硝基壳中的复合碳水化合物和蛋白质，硝基胚胎和成年虱子分泌的物质。 在一种治疗方法中，用梭菌素处理诸如头发的侵染部位，然后用含有蛋白酶和糖苷酶的组合物进行处理，并通过洗涤来除去尼丝。

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