公开(公告)号：US20120052125A1

公开(公告)日：2012-03-01

申请号：US13055951

申请日：2009-08-04

Applicant: Martin Wieland ,  James A. Hayward

Inventor： Martin Wieland ,  James A. Hayward

IPC: A61K31/575 ,  A61K9/14 ,  B05D3/00 ,  B29C71/00 ,  B29C35/16 ,  A61K9/00 ,  A61P7/04

CPC classification number: A61L15/44 ,  A61L15/20 ,  A61L15/28 ,  A61L15/32 ,  A61L24/0015 ,  A61L24/08 ,  A61L24/102 ,  A61L27/20 ,  A61L27/24 ,  A61L27/54 ,  A61L2300/222 ,  A61L2300/418 ,  A61L2300/45 ,  A61L2400/04

Abstract: The present invention relates to a composition comprising a wound dressing device and cholesteryl sulfate and especially to a composition containing cholesteryl sulfate and at least one carrier material for use as a haemostatic agent, as well as to a method for its preparation and use.

Abstract translation: 本发明涉及包含伤口敷料装置和胆固醇硫酸盐的组合物，特别涉及含有胆固醇硫酸盐和至少一种用作止血剂的载体材料的组合物，以及其制备和使用方法。

公开(公告)号：US08420400B2

公开(公告)日：2013-04-16

申请号：US11954055

申请日：2007-12-11

Applicant: James A. Hayward ,  Ming-Hwa Liang ,  Stephane Shu-Kin-So

Inventor： James A. Hayward ,  Ming-Hwa Liang ,  Stephane Shu-Kin-So

IPC: G01N33/00 ,  C12Q1/68

CPC classification number: C12Q1/6816 ,  C08K5/09 ,  C09D7/63 ,  C09D11/03 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T442/2508 ,  C12Q2563/185

Abstract: A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material.

Abstract translation: 描述了用于认证和验证正品的药物的方法。 用于鉴定片剂的方法包括将与特定的核酸碱基序列相关联的特定核酸材料施用于片剂或胶囊。 该方法还包括收集片剂样品并通过检测特定的核酸材料来验证片剂是真实的。

公开(公告)号：US20090042191A1

公开(公告)日：2009-02-12

申请号：US11954044

申请日：2007-12-11

Applicant: James A. Hayward ,  Ming-Hwa Liang ,  John Davis

Inventor： James A. Hayward ,  Ming-Hwa Liang ,  John Davis

IPC: C12Q1/68 ,  G01N33/00

CPC classification number: C12Q1/6816 ,  C08K5/09 ,  C09D7/63 ,  C09D11/03 ,  C09D11/38 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T442/2508 ,  C12Q2563/185

Abstract: A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The method also comprises collecting a sample of either the ink or toner compound and verifying the ink or toner is genuine by detecting the particular nucleic acid material.

Abstract translation: 描述用于认证和验证正品的物品的方法。 用于认证该项目的方法包括将与特定核酸碱基序列相关联的特定核酸材料施加到墨盒内的墨盒或调色剂外壳内的调色剂化合物中。 该方法还包括收集油墨或调色剂化合物的样品，并通过检测特定的核酸材料来验证油墨或调色剂是真实的。

公开(公告)号：US5874105A

公开(公告)日：1999-02-23

申请号：US594175

申请日：1996-01-31

Applicant: David C. Watkins ,  Thomas J. Vichroski ,  James A. Hayward

Inventor： David C. Watkins ,  Thomas J. Vichroski ,  James A. Hayward

IPC: A61K9/127

CPC classification number: A61K9/1272

Abstract: A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.

Abstract translation: 公开了一种用于封装疏水和亲水物质（即“有效载荷”）的脂质体，其能够在发生触发或控制条件时传递其负载。 形成脂质体以稳定地包封特定的活性剂以形成药剂的递送载体。 递送载体的脂质体在特定环境中是稳定的，但是如果从稳定的环境（例如，特定的pH和/或温度和/或离子强度的特征）传递到改变或不稳定的环境，则其变得不稳定或可渗透，由此递送 他们的有效载荷。

公开(公告)号：US20100285985A1

公开(公告)日：2010-11-11

申请号：US12690799

申请日：2010-01-20

Applicant: Minghwa Liang ,  James A. Hayward ,  Lawrence Jung

Inventor： Minghwa Liang ,  James A. Hayward ,  Lawrence Jung

IPC: C40B30/04 ,  C40B50/00 ,  C40B50/06 ,  C40B40/06

CPC classification number: G07D7/14 ,  C08L89/00 ,  C09D7/65 ,  C09D11/00 ,  C12Q1/6816 ,  C12Q2563/185

Abstract: This invention pertains to methods for generating large quantities of DNA security markers by combinatorial variation techniques using polymorphic fragment length DNA for unique identification security marker applications such as explosive ink used in dye/smoke pack and cash carrying boxes.

Abstract translation: 本发明涉及通过使用多态性片段长度DNA的组合变异技术产生大量DNA安全标记的方法，用于独特的鉴定安全标记应用，例如用于染料/烟雾包装和现金携带盒中的爆炸性油墨。

公开(公告)号：US06183774B2

公开(公告)日：2001-02-06

申请号：US09375683

申请日：1999-08-17

Applicant: Duncan T. Aust ,  Michael A. Ross ,  James M. Wilmott ,  James A. Hayward

Inventor： Duncan T. Aust ,  Michael A. Ross ,  James M. Wilmott ,  James A. Hayward

IPC: A61K9127

CPC classification number: A61K9/1272

Abstract: The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.

Abstract translation: 本发明提供了选自视黄醇，视黄酯以及与烷基铵脂肪酸盐形成的脂质体中的任意组合的维生素A衍生物及其制造方法。 本发明的脂质体可以在预设的触发条件发生时递送维生素A衍生物质。 本发明优选的脂质体是阳离子脂质体。 本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。 包封的维生素A衍生物因此被脂质体稳定。 因此，本发明还提供了一种将维生素A衍生物稳定化在这种脂质体中的方法。 本发明的脂质体用于提供用于治疗皮肤的局部皮肤治疗制剂。

公开(公告)号：US5935572A

公开(公告)日：1999-08-10

申请号：US781643

申请日：1997-01-10

Applicant: James A. Hayward ,  David C. Watkins

Inventor： James A. Hayward ,  David C. Watkins

IPC: A61K38/48 ,  A61K38/54 ,  A61P33/14 ,  A61K38/47 ,  C12N11/02

CPC classification number: A61K38/47 ,  A01N63/00 ,  A61K38/4873 ,  C12Y302/01014 ,  C12Y302/01017 ,  C12Y304/22002 ,  A61K9/127

Abstract: A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the protease from hydrolyzing the glycosidase Separation is accomplished by encapsulating either the protease or glycosidase in a lipidic bilayer vesicle while leaving the other outside the vesicle. The protease and glycosidase destroy complex carbohydrate and protein in nit shells, nit embryos and substances secreted by adult lice. In a method of treatment, an infestation site such as hair is treated with a pediculoside and then with the composition containing a protease and glycosidase, and nits are removed such as by washing.

Abstract translation: 提供了含有蛋白酶和糖苷酶的组合物，用于在治疗虱子感染中除去尼丝。 将蛋白酶和糖苷酶彼此分离，以防止蛋白酶水解糖苷酶。通过将蛋白酶或糖苷酶包封在脂质双层囊泡中，同时将另一个留在囊泡外部来实现分离。 蛋白酶和糖苷酶破坏了硝基壳中的复合碳水化合物和蛋白质，硝基胚胎和成年虱子分泌的物质。 在一种治疗方法中，用梭菌素处理诸如头发的侵染部位，然后用含有蛋白酶和糖苷酶的组合物进行处理，并通过洗涤来除去尼丝。

公开(公告)号：US5437867A

公开(公告)日：1995-08-01

申请号：US33819

申请日：1993-03-19

Applicant: Thomas J. Vichroski ,  Regina A. Costa ,  James A. Hayward

Inventor： Thomas J. Vichroski ,  Regina A. Costa ,  James A. Hayward

IPC: A61K8/33 ,  A61K8/81 ,  A61K9/10 ,  A61K9/107 ,  A61Q19/00

CPC classification number: A61K8/33 ,  A61K8/8147 ,  A61Q19/00 ,  A61K2800/262 ,  A61Q13/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: A cosmetic composition includes (a) ether alcohols conforming to the general formula C.sub.(n) H.sub.(2n+2) O.sub.(n/2), where n is an integer which ranges 4 to 12; (b) a homopolymer of acrylic acid cross-linked with an allyl ether of pentaerythritol or an allyl ether of sucrose, or copolymers of acrylic acid or acrylate derivative/acrylonitrile copolymers, or polyacrylic acid; (c) a fragrance oil or oils, or cosmetically acceptable oils or oily-type materials; and (d) water.

Abstract translation: 化妆品组合物包括（a）符合通式C（n）H（2n + 2）O（n / 2）的醚醇，其中n为4-12的整数; （b）与季戊四醇或蔗糖烯丙基醚的烯丙基醚交联的丙烯酸均聚物，或丙烯酸或丙烯酸酯衍生物/丙烯腈共聚物或聚丙烯酸的共聚物; （c）香料油或油，或化妆品可接受的油或油性物质; 和（d）水。

公开(公告)号：US4999348A

公开(公告)日：1991-03-12

申请号：US131458

申请日：1987-12-11

Applicant: Gheorghe Cioca ,  James A. Hayward ,  Manuel L. Tan ,  Morris Herstein ,  Walter P. Smith

Inventor： Gheorghe Cioca ,  James A. Hayward ,  Manuel L. Tan ,  Morris Herstein ,  Walter P. Smith

IPC: A61K8/02 ,  A61K8/67 ,  A61K9/127 ,  A61K31/07 ,  A61K31/23 ,  A61K31/355 ,  A61Q19/00

CPC classification number: A61Q19/00 ,  A61K31/07 ,  A61K31/23 ,  A61K31/355 ,  A61K8/0295 ,  A61K8/671 ,  A61K8/678 ,  A61K9/1274 ,  A61Q19/08

Abstract: Cosmetic and pharmaceutical compositions and methods comprising delivery systems for the controlled release and enhanced penetration of biologically active materials (e.g., Vitamin A) to the skin. The delivery systems comprise cholesteric liquid crystals wherein the active material is retained within the lamellar molecular structure (i.e., between the molecular sheets) of the cholesteric liquid crystal.

Abstract translation: 化妆品和药物组合物和方法包括用于控制释放和增强生物活性物质（例如维生素A）渗透到皮肤中的递送系统。 递送系统包括胆甾型液晶，其中活性材料保留在胆甾醇型液晶的层状分子结构内（即分子片之间）。

公开(公告)号：US08435541B2

公开(公告)日：2013-05-07

申请号：US12874884

申请日：2010-09-02

Applicant: Joseph D. Ceccoli ,  Brian Costello ,  James A. Hayward ,  Konstantinos M. Lahanas

Inventor： Joseph D. Ceccoli ,  Brian Costello ,  James A. Hayward ,  Konstantinos M. Lahanas

IPC: A61K8/97

CPC classification number: A61Q19/08 ,  A61K8/64 ,  A61K8/97 ,  A61K8/9706 ,  A61K2800/782 ,  A61Q19/005

Abstract: A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.

Abstract translation: 本发明的用于提供基质金属蛋白酶（MMP）抑制活性的皮肤护理方案，金属蛋白酶（TIMP）诱导活性的组织抑制剂）和立即和延迟的抗氧化活性的局部组合物。 优选地，所述局部组合物包含至少一种MMP抑制剂，TIMP诱导剂，银耳银耳（雪母）提取物，山茶花（绿茶）叶提取物和丁香菊（Eugenia caryophyllus）（丁香）提取物。 该组合物可用于抗皱和抗衰老产品，为皮肤提供弹性，坚固度，色调和质地，改善细纹并防止皮肤损伤。