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    Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    3.
    发明授权
    Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders 有权
    定向序列聚合物组合物及其抗体的合成用于治疗蛋白质构象障碍

    公开(公告)号：US08546532B2

    公开(公告)日：2013-10-01

    申请号：US12386493

    申请日：2009-04-17

    申请人： Dustan Bonnin ,  Eric Zanelli ,  Thomas Mathers

    发明人： Dustan Bonnin ,  Eric Zanelli ,  Thomas Mathers

    IPC分类号： A61K38/00 ,  A61K51/00

    CPC分类号： C07K1/047 ,  C07K16/00 ,  C07K16/18

    摘要： The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

    摘要翻译： 本发明包括用于固相合成可用于治疗和诊断蛋白质构象障碍的定向表位肽混合物的方法，该方法由关于代替碱基的氨基酸的身份和发生频率的一组规则定义 或已知表位的天然氨基酸。 所得组合物是用于治疗用途的相关肽的混合物。 本发明还涉及使用定向表位肽混合物作为抗原产生抗体的方法，以及由该方法产生的抗体可用于治疗和诊断所述蛋白质构象障碍。

    Methods of treating disease with random copolymers
    5.
    发明申请
    Methods of treating disease with random copolymers 审中-公开
    用无规共聚物治疗疾病的方法

    公开(公告)号：US20060194725A1

    公开(公告)日：2006-08-31

    申请号：US11283405

    申请日：2005-11-17

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson ,  Jeff Krieger

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson ,  Jeff Krieger

    IPC分类号： A61K38/17

    CPC分类号： C07K14/435 ,  A61K9/0019 ,  A61K31/785 ,  A61K38/02

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。

    Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    6.
    发明申请
    Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders 有权
    定向序列聚合物组合物及其抗体的合成用于治疗蛋白质构象障碍

    公开(公告)号：US20100080796A1

    公开(公告)日：2010-04-01

    申请号：US12386493

    申请日：2009-04-17

    申请人： Dustan Bonnin ,  Eric Zanelli ,  Thomas Mathers

    发明人： Dustan Bonnin ,  Eric Zanelli ,  Thomas Mathers

    IPC分类号： A61K39/395 ,  C07K1/00 ,  A61K38/16 ,  C12P21/00 ,  C07K16/00 ,  G01N33/53 ,  A61P43/00

    CPC分类号： C07K1/047 ,  C07K16/00 ,  C07K16/18

    摘要： The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

    摘要翻译： 本发明包括用于固相合成可用于治疗和诊断蛋白质构象障碍的定向表位肽混合物的方法，该方法由关于代替碱基的氨基酸的身份和发生频率的一组规则定义 或已知表位的天然氨基酸。 所得组合物是用于治疗用途的相关肽的混合物。 本发明还涉及使用定向表位肽混合物作为抗原产生抗体的方法，以及由该方法产生的抗体可用于治疗和诊断所述蛋白质构象障碍。

    Methods of treating disease with random copolymers
    7.
    发明授权
    Methods of treating disease with random copolymers 有权
    用无规共聚物治疗疾病的方法

    公开(公告)号：US07655221B2

    公开(公告)日：2010-02-02

    申请号：US11283406

    申请日：2005-11-17

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    IPC分类号： A61K31/74 ,  A61K38/02

    CPC分类号： A61K38/02 ,  A61K38/16 ,  A61K2300/00

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。

    METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS
    8.
    发明申请
    METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS 有权
    用随机共聚物治疗疾病的方法

    公开(公告)号：US20100316714A1

    公开(公告)日：2010-12-16

    申请号：US12637723

    申请日：2009-12-14

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    IPC分类号： A61K38/07 ,  C07K5/107 ,  A61K9/14 ,  A61P37/00

    CPC分类号： A61K38/02 ,  A61K38/16 ,  A61K2300/00

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。

    Methods of treating disease with random copolymers
    9.
    发明授权
    Methods of treating disease with random copolymers 有权
    用无规共聚物治疗疾病的方法

    公开(公告)号：US08475779B2

    公开(公告)日：2013-07-02

    申请号：US12637723

    申请日：2009-12-14

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    IPC分类号： A61K9/107 ,  A61K31/74 ,  A61K38/02

    CPC分类号： A61K38/02 ,  A61K38/16 ,  A61K2300/00

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。