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公开(公告)号：US09387247B2
公开(公告)日：2016-07-12
申请号：US14244405
申请日：2014-04-03
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US09988453B2
公开(公告)日：2018-06-05
申请号：US15048785
申请日：2016-02-19
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison J. Witte , Haichun Huang
IPC分类号： C12N5/10 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/13 , C12N15/62 , C07K16/28 , C07K16/30 , A61K47/48 , A61K51/10 , A61K47/68 , C07H21/00 , A61K39/00
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
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公开(公告)号：US09296822B2
公开(公告)日：2016-03-29
申请号：US14074168
申请日：2013-11-07
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison J. Witte , Haichun Huang
IPC分类号： A61K39/395 , A61K39/00 , C07K16/30 , C07K16/28
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
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公开(公告)号：US10441655B2
公开(公告)日：2019-10-15
申请号：US15288545
申请日：2016-10-07
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：US09266945B2
公开(公告)日：2016-02-23
申请号：US13794265
申请日：2013-03-11
发明人： Gerald Siu , Wenyan Shen , Steven K. Yoshinaga , Haichun Huang
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
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6.发明申请Human Anti-NGF Neutralizing Antibodies As Selective NGF Pathway Inhibitors 审中-公开人类抗NGF中和抗体作为选择性NGF途径抑制剂公开(公告)号：US20160237147A1
公开(公告)日：2016-08-18
申请号：US15000771
申请日：2016-01-19
发明人： Kenneth D. Wild, JR. , James J.S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译： 本发明提供与人神经生长因子（NGF）相互作用或结合的抗体，从而中和NGF的功能。 本发明还提供了所述抗体的药物组合物和中和NGF功能的方法，特别是通过施用药学上有效量的抗NGF抗体来治疗NGF相关疾病（例如慢性疼痛）。 还提供了使用抗NGF抗体检测样品中NGF量的方法。
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公开(公告)号：US20160168249A1
公开(公告)日：2016-06-16
申请号：US15048785
申请日：2016-02-19
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison J. Witte , Haichun Huang
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症的方法。
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