公开(公告)号：US20250143875A1

公开(公告)日：2025-05-08

申请号：US19015448

申请日：2025-01-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Elena Sherman

IPC: A61F2/24

Abstract: A prosthetic valve can include an annular frame that is radially expandable and compressible, a skirt member attached to the annular frame, and a protective member attached to an inner surface the skirt member. The protective member is less abrasive than the skirt member and extends circumferentially around at least a portion of the annular frame.

公开(公告)号：US12023417B2

公开(公告)日：2024-07-02

申请号：US16933866

申请日：2020-07-20

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Tamir S. Levi ,  Elena Sherman

IPC: A61L27/36 ,  A61F2/24 ,  B29C55/02 ,  B29L31/00

CPC classification number: A61L27/3691 ,  A61F2/2415 ,  A61L27/3625 ,  A61L27/3641 ,  B29C55/02 ,  A61F2240/001 ,  A61L2430/20 ,  A61L2430/40 ,  B29K2995/0056 ,  B29L2031/7534

Abstract: A method is provided for pre-stretching implantable biocompatible materials, such as material to be incorporated into an implantable device. A sheet of implantable biocompatible material is attached to one or more tensioning members, where tension is applied along one or more axes. Tension is applied for a period of time, and at an appropriate force, to produce a desired degree of thinning or pre-stretching of the implantable biocompatible material. During the tensioning, the implantable biocompatible material is maintained at an elevated temperature, such as a temperature that is at least substantially a temperature of an environment into which the material will be implanted.

公开(公告)号：US20230143332A1

公开(公告)日：2023-05-11

申请号：US18095440

申请日：2023-01-10

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Nikolai Gurovich ,  Elena Sherman ,  Ziv Yohanan

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0075 ,  A61F2220/0091

Abstract: The present invention relates to implantable prosthetic devices, such as prosthetic heart valves, and to attachment configurations and methods of attaching soft components, such as leaflets or skirts, to frames of such prosthetic valves.

公开(公告)号：US20220409366A1

公开(公告)日：2022-12-29

申请号：US17901602

申请日：2022-09-01

Applicant: Edwards Lifesciences Corporation

Inventor： Michael Bukin ,  Noam Nir ,  Tamir S. Levi ,  Ziv Yohanan ,  Elena Sherman ,  Eran Goldberg ,  David Maimon

IPC: A61F2/24

Abstract: A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including a plurality of leaflets is disclosed. As one example, a prosthetic heart valve includes a frame; a plurality of commissure support elements, each connected the frame and including two axially-extending members spaced apart from one another to form a window; and a plurality of leaflets, each leaflet comprising a body and two opposing commissure tabs, each commissure tab arranged adjacent to another commissure tab to form a pair of commissure tabs that are disposed in a commissure support element to form a commissure. Each commissure tab includes a series of overlapping layers that include a first set of two overlapping layers that extends through the window and a second set of two overlapping layers that extends away from the first set of two overlapping layers and over an outer side of a corresponding axially-extending member.

公开(公告)号：US20220387175A1

公开(公告)日：2022-12-08

申请号：US17889309

申请日：2022-08-16

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Noam Nir ,  Elena Sherman

IPC: A61F2/24

Abstract: A prosthetic heart valve comprises an annular frame that is radially compressible and expandable between a radially compressed state and a radially expanded state, wherein the frame elongates in an axial direction when radially compressed from the radially expanded state to the radially compressed state. Leaflets are coupled to the frame such that when the frame is in the radially expanded state, the leaflets have slack in an axial direction, wherein when the frame is radially compressed to a partially radially compressed state between the radially expanded state and the radially compressed state, the leaflets are in a relaxed state, and wherein when the frame is in the radially compressed state, the leaflets are stretched in the axial direction.

公开(公告)号：US20220257367A1

公开(公告)日：2022-08-18

申请号：US17732985

申请日：2022-04-29

Applicant: Edwards Lifesciences Corporation

Inventor： Yair A. Neumann ,  Oren Cohen ,  Khen Perlmutter ,  Eitan Atias ,  Noam Miller ,  Eran Goldberg ,  Anatoly Dvorsky ,  Tamir S. Levi ,  Haim Yushtein ,  Danny M. Garmahi ,  Ziv Yohanan ,  Michael Bukin ,  Noam Nir ,  Elena Sherman ,  Gideon Sagi

IPC: A61F2/24

Abstract: An implantable prosthetic valve can include a frame movable between a radially compressed and a radially expanded configuration. The frame can include a first strut having a first locking feature disposed on a radially facing inner surface of the strut and a second strut having a second locking feature disposed on a radially facing outer surface of the strut. The first and second locking features can engage each other so as to allow pivoting of the first and second struts relative to one another in a first direction upon radial expansion of the frame and resist pivoting of the first and second struts relative to one another in a second direction to resist radial compression of the frame.

公开(公告)号：US20220233305A1

公开(公告)日：2022-07-28

申请号：US17658584

申请日：2022-04-08

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US20220160507A1

公开(公告)日：2022-05-26

申请号：US17670290

申请日：2022-02-11

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Alexey Tsypenyuk

IPC: A61F2/24

Abstract: A prosthetic heart valve and delivery device for delivering the prosthetic heart valve to a target implantation site, which reduce contact between the prosthetic heart valve and a delivery sheath through which the delivery device is advanced to the target implantation site, is disclosed. As one example, a prosthetic heart valve may comprise a frame including a first end with a plurality of apices spaced apart from one another around a circumference of the first end and a cover element covering the plurality of apices. The cover element may include a cushioning element or a bio-resorbable element.

公开(公告)号：US20220160505A1

公开(公告)日：2022-05-26

申请号：US17669138

申请日：2022-02-10

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin ,  Ziv Yohanan ,  Tamir S. Levi ,  Elena Sherman

IPC: A61F2/24

Abstract: Disclosed are techniques for construction of prosthetic heart valves, particularly techniques for attachment of scalloped edges of valvular leaflets to struts of mechanical frames using sutures and/or other materials as intermediate coupling members. In some embodiments, the scalloped edges of the leaflets are coupled to the segments of the struts of the frame via suture loops that are oriented transverse to the scalloped edges of the leaflets. In some embodiments, central portions of scallop line segments are attached to the scalloped edges of the leaflets and are not attached to the frame. In some embodiments, strut segments are tapered to limit translation of suture loops. In some embodiments, a cloth strip couples the scalloped edges of the leaflets to frame struts. In some embodiments, the scalloped edge is attached to adjacent segments of intersecting struts via sliding suture loops, where the adjacent segments join at a common pivot joint.

公开(公告)号：US11273031B2

公开(公告)日：2022-03-15

申请号：US16799741

申请日：2020-02-24

Applicant: Edwards Lifesciences Corporation

Inventor： Tomer Saar ,  Michael Bukin ,  Elena Sherman ,  Alexander Barash ,  Yana Mayatskaya

IPC: A61F2/24

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.