公开(公告)号：US11267821B2

公开(公告)日：2022-03-08

申请号：US16807335

申请日：2020-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yoshiaki Ohashi ,  Yoshihiko Norimine ,  Tamaki Hoshikawa ,  Yu Yoshida ,  Yoshihisa Kobayashi ,  Nobuhiro Sato ,  Koji Hagiwara ,  Nobuaki Sato ,  Shinsuke Hirota ,  Takaaki Harada ,  Hikaru Yoshimura

IPC: C07D495/22 ,  A61K31/551 ,  A61P25/00 ,  C07D491/22 ,  C07D491/147

Abstract: The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:

公开(公告)号：US20170137436A1

公开(公告)日：2017-05-18

申请号：US15346912

申请日：2016-11-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Toshiki Kurokawa ,  Yu Yoshida ,  Kogyoku Shin ,  Yoshihisa Kobayashi ,  Hironori Fukumoto ,  Kunitoshi Takeda ,  Yoshiaki Ohashi ,  Makoto Kotake ,  Tomoyuki Shibuguchi ,  Toru Watanabe ,  Yoichi Kita ,  Shinsuke Hirota ,  Takashi Fukuyama ,  Yasuaki Kamada

IPC: C07D491/147 ,  C07D491/052

CPC classification number: C07D491/147 ,  C07D491/052

Abstract: Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:

公开(公告)号：US10227349B2

公开(公告)日：2019-03-12

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The disclosure provides pyrazolo[1,5-a]pyrimidine compounds, and pharmaceutically acceptable salts thereof, having protease-activated receptor 2 (PAR2) inhibitory action, pharmaceutical compositions containing the same, and methods of treatment using the same.

公开(公告)号：US09975910B2

公开(公告)日：2018-05-22

申请号：US14904860

申请日：2014-07-18

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Keigo Tanaka ,  Takashi Fukuyama ,  Norio Murai ,  Wataru Itano ,  Shinsuke Hirota ,  Daisuke Iida ,  Hiroshi Azuma

IPC: C07D491/048 ,  C07F7/22 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/02

CPC classification number: C07F7/2208 ,  C07D491/048 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/02 ,  C07F5/025 ,  C07F5/027

Abstract: A compound represented by the formula (I) or a salt thereof: wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms in the ring; X1 is a hydrogen atom, a hydroxy group, a hydroxy C1-6 alkyl group, —B(OH)2, a boronate ester group, a cyclic boronate ester group, a boranyl group, a cyclic boranyl group, —BF3Mn1, —Sn(R12)(R13)(R14), a leaving group, a carboxy group, a formyl group, or —NR16R17; and X2 is a hydrogen atom or —CO2R18.

公开(公告)号：US09738656B2

公开(公告)日：2017-08-22

申请号：US15346912

申请日：2016-11-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Toshiki Kurokawa ,  Yu Yoshida ,  Kogyoku Shin ,  Yoshihisa Kobayashi ,  Hironori Fukumoto ,  Kunitoshi Takeda ,  Yoshiaki Ohashi ,  Makoto Kotake ,  Tomoyuki Shibuguchi ,  Toru Watanabe ,  Yoichi Kita ,  Shinsuke Hirota ,  Takashi Fukuyama ,  Yasuaki Kamada

IPC: C07D491/147 ,  C07D491/052

CPC classification number: C07D491/147 ,  C07D491/052

Abstract: Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:

公开(公告)号：US20180057499A1

公开(公告)日：2018-03-01

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The compounds represented by formulas (I) to (XVIII) or pharmaceutically acceptable salts thereof.

公开(公告)号：US11358972B2

公开(公告)日：2022-06-14

申请号：US16807335

申请日：2020-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yoshiaki Ohashi ,  Yoshihiko Norimine ,  Tamaki Hoshikawa ,  Yu Yoshida ,  Yoshihisa Kobayashi ,  Nobuhiro Sato ,  Koji Hagiwara ,  Nobuaki Sato ,  Shinsuke Hirota ,  Takaaki Harada ,  Hikaru Yoshimura

IPC: C07D495/22 ,  A61K31/551 ,  A61P25/00 ,  C07D491/22 ,  C07D491/147

Abstract: The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:

公开(公告)号：US20200283452A1

公开(公告)日：2020-09-10

申请号：US16807335

申请日：2020-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yoshiaki Ohashi ,  Yoshihiko Norimine ,  Tamaki Hoshikawa ,  Yu Yoshida ,  Yoshihisa Kobayashi ,  Nobuhiro Sato ,  Koji Hagiwara ,  Nobuaki Sato ,  Shinsuke Hirota ,  Takaaki Harada ,  Hikaru Yoshimura

IPC: C07D495/22 ,  C07D491/147 ,  C07D491/22

Abstract: The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:

公开(公告)号：US20160168176A1

公开(公告)日：2016-06-16

申请号：US14904860

申请日：2014-07-18

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Keigo Tanaka ,  Takashi Fukuyama ,  Norio Murai ,  Wataru Itano ,  Shinsuke Hirota ,  Daisuke Iida ,  Hiroshi Azuma

IPC: C07F7/22 ,  C07F5/02 ,  C07D495/04 ,  C07D513/04 ,  C07D491/048 ,  C07D493/04

CPC classification number: C07F7/2208 ,  C07D491/048 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/02 ,  C07F5/025 ,  C07F5/027

Abstract: A compound represented by the formula (I) or a salt thereof: wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms in the ring; X1 is a hydrogen atom, a hydroxy group, a hydroxy C1-6 alkyl group, —B(OH)2, a boronate ester group, a cyclic boronate ester group, a boranyl group, a cyclic boranyl group, —BF3Mn1, —Sn(R12)(R13)(R14), a leaving group, a carboxy group, a formyl group, or —NR16R17; and X2 is a hydrogen atom or —CO2R18.

Abstract translation: 由式（I）表示的化合物或其盐：其中环Z是环中具有一个或两个杂原子的5至6元杂芳环; X1是氢原子，羟基，羟基C1-6烷基，-B（OH）2，硼酸酯基，环状硼酸酯基，硼烷基，环状硼烷基，-BF3Mn1，-Sn （R 12）（R 13）（R 14），离去基团，羧基，甲酰基或-NR 16 R 17; X 2为氢原子或-CO 2 R 18。