-
公开(公告)号：US20200061495A1
公开(公告)日：2020-02-27
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
-
公开(公告)号：US11547957B2
公开(公告)日：2023-01-10
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
-
公开(公告)号：US20210047430A1
公开(公告)日：2021-02-18
申请号：US17088659
申请日：2020-11-04
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Chia-Yun Sun , Melissa Holstein , Kristen Cotoni , Matthew T. Stone , Santosh Rahane
IPC: C07K16/34 , C07K1/22 , B01D15/38 , B01D15/42 , B01D15/20 , B01J20/289 , B01J20/285 , B01J20/32
Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
-
-
Search Results
3
records
(took 0.01 seconds)
