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公开(公告)号：US09274092B2
公开(公告)日：2016-03-01
申请号：US14819806
申请日：2015-08-06
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Anthony Frederick Mann , Daniel Schubnel
CPC classification number: G01N30/56 , B01D15/206 , B01D15/3809 , G01N2030/565
Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.
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Patent Agency Ranking
公开(公告)号：US20150361129A1
公开(公告)日：2015-12-17
申请号：US14736596
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
CPC classification number: C07K1/18 , A61L2/0017 , B01D15/08 , B01D15/12 , B01D61/145 , B01D2311/08 , B01D2313/58 , B01D2315/10 , B01D2315/16 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/00 , C07K16/065 , C07K2317/14 , B01D2311/2626
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
Abstract translation: 在各种实施方案中，本发明提供了从样品中分离靶蛋白与非靶蛋白的方法，包括增加样品中靶蛋白和非靶蛋白的浓度，并随后将浓缩样品递送至色谱装置。 在其它实施方案中，本发明涉及通过将含有靶蛋白的浓缩样品递送至色谱装置来增加靶蛋白色谱装置的容量的方法。
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公开(公告)号：US12297229B2
公开(公告)日：2025-05-13
申请号：US16259489
申请日：2019-01-28
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/34 , B01D15/08 , B01D15/12 , B01D61/14 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C07K16/06 , A61L2/00
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US20190153027A1
公开(公告)日：2019-05-23
申请号：US16259489
申请日：2019-01-28
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/18 , C07K16/00 , B01D15/08 , C07K1/22 , C07K1/36 , B01D61/14 , C07K16/06 , C07K1/34 , B01D15/12
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US10550148B2
公开(公告)日：2020-02-04
申请号：US14736596
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/34 , C07K1/18 , C07K16/00 , C07K1/22 , B01D15/08 , B01D61/14 , C07K16/06 , C07K1/36 , B01D15/12 , A61L2/00
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US20150346169A1
公开(公告)日：2015-12-03
申请号：US14819806
申请日：2015-08-06
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Anthony Frederick Mann , Daniel Schubnel
CPC classification number: G01N30/56 , B01D15/206 , B01D15/3809 , G01N2030/565
Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.
Abstract translation: 一种用于包装色谱柱的方法和装置，所述色谱柱由连接到所述塔的顶部和/或底部凸缘的一个或多个振动装置形成。 介质以一个或多个步骤添加到塔中，允许在重力作用下沉降，然后经受来自振动装置的一个或多个振动处理，直到获得适当填充的塔。 用于在放置到柱中时将介质悬浮的液体可以在振动步骤之前或期间至少部分地去除。 在获得包装后，剩余的液体被去除或更换。
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