公开(公告)号：US20180320125A1

公开(公告)日：2018-11-08

申请号：US15781370

申请日：2016-12-02

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Katia Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M1/42 ,  C12M1/12 ,  C12M3/06 ,  C12N5/071 ,  C12N5/077 ,  C12M1/00 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50

CPC classification number: C12M35/04 ,  C12M23/16 ,  C12M23/38 ,  C12M25/02 ,  C12M35/08 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0688 ,  C12N5/069 ,  C12N5/0697 ,  C12N5/0698 ,  C12N2501/165 ,  G01N33/50 ,  G01N33/5082 ,  G01N33/54366

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US20220033757A1

公开(公告)日：2022-02-03

申请号：US17494221

申请日：2021-10-05

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M1/42 ,  C12M3/06 ,  C12M1/12 ,  G01N33/50 ,  G01N33/543 ,  C12M1/00 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US20210214670A1

公开(公告)日：2021-07-15

申请号：US17160617

申请日：2021-01-28

Applicant: Emulate, Inc.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M1/42 ,  C12M3/06 ,  C12M1/12 ,  G01N33/50 ,  G01N33/543 ,  C12M1/00 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US11859165B2

公开(公告)日：2024-01-02

申请号：US18097755

申请日：2023-01-17

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12M1/42 ,  G01N33/50 ,  G01N33/543 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

CPC classification number: C12M35/04 ,  C12M23/16 ,  C12M23/38 ,  C12M25/02 ,  C12M35/08 ,  C12N5/069 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0688 ,  C12N5/0697 ,  C12N5/0698 ,  G01N33/50 ,  G01N33/5082 ,  G01N33/54366 ,  C12N2501/165

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US20230287324A1

公开(公告)日：2023-09-14

申请号：US18097755

申请日：2023-01-17

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M1/42 ,  C12M3/06 ,  C12M1/12 ,  G01N33/50 ,  G01N33/543 ,  C12M1/00 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

CPC classification number: C12M35/04 ,  C12M23/16 ,  C12M23/38 ,  C12M25/02 ,  C12M35/08 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0688 ,  C12N5/069 ,  C12N5/0697 ,  C12N5/0698 ,  G01N33/50 ,  G01N33/5082 ,  G01N33/54366 ,  C12N2501/165

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US11248203B2

公开(公告)日：2022-02-15

申请号：US17160617

申请日：2021-01-28

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M3/06 ,  C12M1/12 ,  C12M1/00 ,  C12M1/42 ,  G01N33/50 ,  G01N33/543 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：US10961496B2

公开(公告)日：2021-03-30

申请号：US15781370

申请日：2016-12-02

Applicant: EMULATE, INC.

Inventor： Daniel Levner ,  Christopher David Hinojosa ,  Norman Wen ,  Antonio Varone ,  Justin Nguyen ,  Lina Williamson ,  S. Jordan Kerns ,  Catherine Karalis ,  Geraldine Hamilton ,  Carol Lucchesi

IPC: C12M1/42 ,  C12M3/06 ,  C12M1/12 ,  G01N33/50 ,  G01N33/543 ,  C12M1/00 ,  C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  C12N5/077

Abstract: A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.