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公开(公告)号：US12091650B2
公开(公告)日：2024-09-17
申请号：US16286185
申请日：2019-02-26
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC分类号： C12M23/16 , B01L3/502715 , C12M25/02 , C12N5/0068 , C12N5/0619 , C12N5/0622 , C12N5/069 , B01L2200/0647 , B01L2300/0861 , C12N2502/081 , C12N2502/28 , C12N2506/02 , C12N2506/45 , C12N2531/00 , C12N2539/00
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20240200006A1
公开(公告)日：2024-06-20
申请号：US18591786
申请日：2024-02-29
申请人： EMULATE, Inc.
摘要： The present invention is related to the field of fluidic devices, and in particular, microfluidic cell culture systems. The present invention provides pumping, recirculation and sampling for a microfluidic device or devices. The present invention provides solutions to the control of microfluidics for both terrestrial and space applications, including the control over the movement of fluids in zero gravity or microgravity.
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公开(公告)号：US11697792B2
公开(公告)日：2023-07-11
申请号：US16712439
申请日：2019-12-12
申请人： EMULATE, INC.
CPC分类号： C12M29/10 , B01L3/502738 , C12M23/16 , C12M29/14 , B01L2300/0861 , B01L2400/0605 , C12M33/00 , G01N1/18
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.
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公开(公告)号：US20220282221A1
公开(公告)日：2022-09-08
申请号：US17678485
申请日：2022-02-23
发明人： S. Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher David Hinojosa , Jacob Fraser , Jefferson Puerta , Geraldine Hamilton , Robert Barrett , Clive Svendsen , Daniel Levner , Stephen R. Targan , Michael Workman , Dhruv Sareen , Uthra Rajamani , Magdalena Kasendra
摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：US20220155328A1
公开(公告)日：2022-05-19
申请号：US17538518
申请日：2021-11-30
申请人： EMULATE, Inc.
发明人： JOSIAH SLIZ , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
摘要： The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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公开(公告)号：US11248203B2
公开(公告)日：2022-02-15
申请号：US17160617
申请日：2021-01-28
申请人： EMULATE, INC.
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Antonio Varone , Justin Nguyen , Lina Williamson , S. Jordan Kerns , Catherine Karalis , Geraldine Hamilton , Carol Lucchesi
IPC分类号： C12M3/06 , C12M1/12 , C12M1/00 , C12M1/42 , G01N33/50 , G01N33/543 , C12N5/0793 , C12N5/079 , C12N5/071 , C12N5/077
摘要： A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.
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公开(公告)号：US10989721B2
公开(公告)日：2021-04-27
申请号：US15648162
申请日：2017-07-12
申请人： Emulate Inc.
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
摘要： Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10974242B2
公开(公告)日：2021-04-13
申请号：US15647853
申请日：2017-07-12
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US10961496B2
公开(公告)日：2021-03-30
申请号：US15781370
申请日：2016-12-02
申请人： EMULATE, INC.
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Antonio Varone , Justin Nguyen , Lina Williamson , S. Jordan Kerns , Catherine Karalis , Geraldine Hamilton , Carol Lucchesi
IPC分类号： C12M1/42 , C12M3/06 , C12M1/12 , G01N33/50 , G01N33/543 , C12M1/00 , C12N5/0793 , C12N5/079 , C12N5/071 , C12N5/077
摘要： A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.
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公开(公告)号：US10689608B2
公开(公告)日：2020-06-23
申请号：US16108827
申请日：2018-08-22
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
IPC分类号： B01L3/00 , C12M1/00 , C12M1/16 , C12M3/00 , C12N5/071 , C12M3/06 , C12M1/42 , C12M1/34 , A01N1/02 , C12M1/36 , B01L9/00
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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