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    Processes and kits for determining multi-drug resistance of cells
    1.
    发明授权
    Processes and kits for determining multi-drug resistance of cells 有权
    确定细胞多药耐药的方法和试剂盒

    公开(公告)号：US09097673B2

    公开(公告)日：2015-08-04

    申请号：US13864524

    申请日：2013-04-17

    申请人： ENZO LIFE SCIENCES, INC.

    发明人： Irina Lebedeva ,  Praveen Pande ,  Wayne Forrest Patton

    IPC分类号： C12M1/34 ,  G01N21/64 ,  G01N33/50

    CPC分类号： G01N21/6486 ,  G01N33/502 ,  G01N2800/44

    摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDR1, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.

    摘要翻译： 本发明涉及细胞中的多药耐药性（MDR），以及某些呫吨化合物用于测定细胞耐药性的用途以及受试化合物对膜转运体MDR1，MRP和BCRP对细胞膜转运的影响。 描述和提供了用于进行这些测定和测量这些影响的方法和试剂盒。

    SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION
    2.
    发明申请
    SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION 审中-公开

    公开(公告)号：US20190119719A1

    公开(公告)日：2019-04-25

    申请号：US16177676

    申请日：2018-11-01

    申请人： ENZO LIFE SCIENCES, INC.

    发明人： Irina Lebedeva ,  Wayne Forrest Patton ,  Maciej Szczepanik ,  Yuejun Xiang ,  Praveen Pande

    IPC分类号： C12Q1/26 ,  C12Q1/48 ,  C07D311/08 ,  C07D491/052 ,  C07D491/20 ,  C09K11/06 ,  C12Q1/44 ,  C12Q1/37 ,  C07D493/10

    摘要： Provided is a compound having the structure: (SIG)-(SI-MOD)m where SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. When MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided are methods of determining whether a sample, such as a cell, comprises an activator, such as a nitroreducase, using the compound. Further provided are methods of determining whether a mammalian cell is hypoxic using the compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase using the compound where nitroreductase is the activator is also provided.

    Self-immolative probes for enzyme activity detection
    4.
    发明授权
    Self-immolative probes for enzyme activity detection 有权

    公开(公告)号：US10718005B2

    公开(公告)日：2020-07-21

    申请号：US16177676

    申请日：2018-11-01

    申请人： ENZO LIFE SCIENCES, INC.

    发明人： Irina Lebedeva ,  Wayne Forrest Patton ,  Maciej Szczepanik ,  Yuejun Xiang ,  Praveen Pande

    IPC分类号： C12Q1/26 ,  C09K11/06 ,  C12Q1/37 ,  C12Q1/44 ,  C12Q1/48 ,  C07D311/08 ,  C07D491/052 ,  C07D491/20 ,  C07D493/10

    摘要： Provided is a compound having the structure: (SIG)-(SI-MOD)m where SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. When MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided are methods of determining whether a sample, such as a cell, comprises an activator, such as a nitroreducase, using the compound. Further provided are methods of determining whether a mammalian cell is hypoxic using the compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase using the compound where nitroreductase is the activator is also provided.