公开(公告)号：US20220056526A1

公开(公告)日：2022-02-24

申请号：US17409132

申请日：2021-08-23

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  G01N33/533 ,  G01N33/574 ,  C12Q1/6886 ,  G16Z99/00 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US11193168B2

公开(公告)日：2021-12-07

申请号：US16789279

申请日：2020-02-12

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827 ,  C12N15/65 ,  C01B17/48

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US20190177769A1

公开(公告)日：2019-06-13

申请号：US15841006

申请日：2017-12-13

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12N15/65

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US20200248233A1

公开(公告)日：2020-08-06

申请号：US16789279

申请日：2020-02-12

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827 ,  C12N15/65

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US10648025B2

公开(公告)日：2020-05-12

申请号：US15841006

申请日：2017-12-13

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827 ,  C12P19/34 ,  C12N15/65 ,  C01B17/48

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US20220119862A1

公开(公告)日：2022-04-21

申请号：US17520075

申请日：2021-11-05

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US11118228B2

公开(公告)日：2021-09-14

申请号：US15881409

申请日：2018-01-26

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  C12Q1/6886 ,  G01N33/533 ,  G16Z99/00 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US20180245157A1

公开(公告)日：2018-08-30

申请号：US15881409

申请日：2018-01-26

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6809

CPC classification number: C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/533 ,  G01N33/57419 ,  G16Z99/00

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.