公开(公告)号：US20220119862A1

公开(公告)日：2022-04-21

申请号：US17520075

申请日：2021-11-05

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US11118228B2

公开(公告)日：2021-09-14

申请号：US15881409

申请日：2018-01-26

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  C12Q1/6886 ,  G01N33/533 ,  G16Z99/00 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US11104960B2

公开(公告)日：2021-08-31

申请号：US16570782

申请日：2019-09-13

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q1/6883 ,  G01N33/574

Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

公开(公告)号：US10683555B2

公开(公告)日：2020-06-16

申请号：US15978565

申请日：2018-05-14

Applicant: Mayo Foundation for Medical Education and Research ,  EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

公开(公告)号：US20190218601A1

公开(公告)日：2019-07-18

申请号：US16318580

申请日：2017-07-19

Applicant: Exact Sciences Development Company, LLC

Inventor： Hatim T. Allawi ,  Graham P. Lidgard

IPC: C12Q1/6827

CPC classification number: C12Q1/6827 ,  C12Q2523/125 ,  C12Q2531/113 ,  C12Q2545/101 ,  C12Q2561/109 ,  C12Q2600/154

Abstract: Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject. The technology also relates to use of endogenous methylated DNAs as internal controls for marker gene methylation assays.

公开(公告)号：US20180245157A1

公开(公告)日：2018-08-30

申请号：US15881409

申请日：2018-01-26

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6809

CPC classification number: C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/533 ,  G01N33/57419 ,  G16Z99/00

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US10011878B2

公开(公告)日：2018-07-03

申请号：US14966938

申请日：2015-12-11

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David Alan Ahlquist ,  William Russell Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi ,  Abram Michael Vaccaro

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/166

Abstract: Provided herein is technology relating to performing methylation assays. In particular, the technology relates to internal controls for methylation assays.

公开(公告)号：US09994911B2

公开(公告)日：2018-06-12

申请号：US14775435

申请日：2014-03-12

Applicant: Mayo Foundation for Medical Education and Research ,  EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.

公开(公告)号：US11118230B2

公开(公告)日：2021-09-14

申请号：US16013240

申请日：2018-06-20

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David Alan Ahlquist ,  William Russell Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi ,  Abram Michael Vaccaro

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886

Abstract: Provided herein is technology relating to performing methylation assays. In particular, the technology relates to internal controls for methylation assays.

公开(公告)号：US20210207224A1

公开(公告)日：2021-07-08

申请号：US17205796

申请日：2021-03-18

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.