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公开(公告)号：US20110250229A1
公开(公告)日：2011-10-13
申请号：US12921151
申请日：2009-03-03
CPC分类号： A61K39/0011 , A61K35/12 , A61K35/42 , A61K2039/5152 , A61K2039/5156
摘要： Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen.
摘要翻译： 通过频繁施用分泌修饰的热休克蛋白（例如，gp96）的同种异体癌细胞的受试者，受试者中的B细胞的消耗或两者都可以改善基于细胞的免疫治疗（例如免疫或疫苗接种）。 抗原（例如衍生自同种异体或同基因癌细胞的新抗原或肿瘤抗原的表位）可诱导受试者的特异性免疫应答。 例如，与分泌的热休克蛋白结合在免疫原性复合物中的表位可以从共表达分泌的gp96和抗原的同种异体癌细胞或仅表达抗原的受试者的同基因癌细胞获得。
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公开(公告)号：US08475785B2
公开(公告)日：2013-07-02
申请号：US12921151
申请日：2009-03-03
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K35/12 , A61K35/42 , A61K2039/5152 , A61K2039/5156
摘要： Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen.
摘要翻译： 通过频繁施用分泌修饰的热休克蛋白（例如，gp96）的同种异体癌细胞的受试者，受试者中的B细胞的消耗或两者都可以改善基于细胞的免疫治疗（例如免疫或疫苗接种）。 抗原（例如衍生自同种异体或同基因癌细胞的新抗原或肿瘤抗原的表位）可诱导受试者的特异性免疫应答。 例如，与分泌的热休克蛋白结合在免疫原性复合物中的表位可以从共表达分泌的gp96和抗原的同种异体癌细胞或仅表达抗原的受试者的同基因癌细胞获得。
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3.发明授权Recombinant cancer cell secreting modified heat shock protein-antigenic peptide complex 有权重组癌细胞分泌修饰热休克蛋白抗原肽复合物公开(公告)号：US08685384B2
公开(公告)日：2014-04-01
申请号：US11878460
申请日：2007-07-24
CPC分类号： A61K47/4833 , A61K38/00 , A61K39/385 , A61K47/646 , A61K47/68 , A61K2039/6043 , A61K2039/622 , C07K14/47 , C07K2319/00 , C07K2319/30 , Y02A50/403 , Y02A50/41 , Y02A50/466
摘要： The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases.
摘要翻译： 本发明涉及纯化与癌症或感染细胞的抗原肽非共价结合的修饰的热休克蛋白的免疫原性，预防和治疗有效复合物的方法。 要求保护的方法包括构建编码可分泌修饰的热休克蛋白的核苷酸序列，在合适的宿主细胞中表达该序列，从细胞培养物和细胞中回收免疫原性复合物，并通过亲和层析纯化免疫原性复合物。 通过大规模培养含有遗传序列的宿主细胞可以获得大量的这样的免疫原性复合物。 该复合物可用作疫苗以引发针对癌症或感染细胞的特异性免疫应答，以及治疗或预防癌症或传染性疾病。
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公开(公告)号：US11163246B2
公开(公告)日：2021-11-02
申请号：US17016389
申请日：2020-09-10
IPC分类号： G03G15/08
摘要： A developing device includes a developer bearer and a stirring conveyor. The stirring conveyor includes a first conveying chamber including a conveying member and a second conveying chamber to receive the developer from an end of the first conveying chamber. The conveying member includes a forward winding blade, a reverse winding blade, and a shaft portion on which the forward winding blade and the reverse winding blade are mounted with a space therebetween. A circumferential phase of the conveying member at a start position of the reverse winding blade is different from a circumferential phase of the conveying member at an end position of the forward winding blade. The conveying member is disposed in the first conveying chamber so that the space is opposite a portion at which the second conveying chamber receives the developer from the end of the first conveying chamber.
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公开(公告)号：US10007209B2
公开(公告)日：2018-06-26
申请号：US15604235
申请日：2017-05-24
申请人： Shinnosuke Koshizuka , Koichi Yamazaki , Nobuo Takami , Atsushi Nakamoto , Kazunori Suzuki , Naohiro Kawashima
发明人： Shinnosuke Koshizuka , Koichi Yamazaki , Nobuo Takami , Atsushi Nakamoto , Kazunori Suzuki , Naohiro Kawashima
CPC分类号： G03G15/0812 , G03G15/081 , G03G15/0921 , G03G15/0928
摘要： A developing device includes a developer bearer, a developer regulator disposed opposite the developer bearer across a first gap, and an opposing member having an opposing face disposed opposing the developer bearer across a second gap wider than the first gap. The opposing face is disposed adjacent to and upstream from the developer regulator in a direction of rotation of the developer bearer. The opposing face is inclined relative to an orthogonal plane direction orthogonal to a side face of the developer regulator. The opposing face is inclined to progressively reduce a distance from the developer bearer to the opposing face in a direction of rotation of the developer bearer. A difference between the second gap and the first gap is not greater than 1.75 times as large as the first gap.
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公开(公告)号：US20170351195A1
公开(公告)日：2017-12-07
申请号：US15604235
申请日：2017-05-24
申请人： Shinnosuke Koshizuka , Koichi Yamazaki , Nobuo Takami , Atsushi Nakamoto , Kazunori Suzuki , Naohiro Kawashima
发明人： Shinnosuke Koshizuka , Koichi Yamazaki , Nobuo Takami , Atsushi Nakamoto , Kazunori Suzuki , Naohiro Kawashima
CPC分类号： G03G15/0812 , G03G15/081 , G03G15/0921 , G03G15/0928
摘要： A developing device includes a developer bearer, a developer regulator disposed opposite the developer bearer across a first gap, and an opposing member having an opposing face disposed opposing the developer bearer across a second gap wider than the first gap. The opposing face is disposed adjacent to and upstream from the developer regulator in a direction of rotation of the developer bearer. The opposing face is inclined relative to an orthogonal plane direction orthogonal to a side face of the developer regulator. The opposing face is inclined to progressively reduce a distance from the developer bearer to the opposing face in a direction of rotation of the developer bearer. A difference between the second gap and the first gap is not greater than 1.75 times as large as the first gap.
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公开(公告)号：US08655237B2
公开(公告)日：2014-02-18
申请号：US14019991
申请日：2013-09-06
申请人： Yuji Suzuki , Akihiro Takayama , Kentaro Nodera , Hiroyuki Uenishi , Susumu Tateyama , Shinnosuke Koshizuka , Tatsuya Kubo , Koichi Yamazaki
发明人： Yuji Suzuki , Akihiro Takayama , Kentaro Nodera , Hiroyuki Uenishi , Susumu Tateyama , Shinnosuke Koshizuka , Tatsuya Kubo , Koichi Yamazaki
IPC分类号： G03G15/09
CPC分类号： G03G15/0889 , G03G15/081 , G03G15/0928
摘要： A development device includes a developer bearer to carry the developer to a development range, a magnetic field generator disposed inside the developer bearer for generating magnetic force, a developer regulator for adjusting an amount of the developer, a developer supply compartment disposed adjacent to the developer bearer, separated by a side wall from a portion where the developer bearer is provided, a developer agitator provided in the supply compartment, and a blocker disposed above the side wall of the supply compartment across a supply gap through which the developer moves from the supply compartment. The magnetic field generator has an attraction magnetic pole and a regulation magnetic pole. The blocker prevents the developer blocked by the developer regulator from moving along a magnetic force line of the regulation magnetic force toward the circumferential surface of the developer bearer.
摘要翻译： 显影装置包括将显影剂携带到显影范围的显影剂载体，设置在显影剂载体内部以产生磁力的磁场发生器，用于调节显影剂量的显影剂调节器，与显影剂相邻设置的显影剂供应室 承载体由侧壁与设置有显影剂载体的部分隔开，设置在供应隔室中的显影剂搅拌器和阻挡件，其设置在供应间隔的侧壁上方，跨越供给间隙，显影剂从供应间隙移动， 隔间 磁场发生器具有吸引磁极和调节磁极。 阻挡剂防止由显影剂调节器阻挡的显影剂沿着调节磁力的磁力线朝着显影剂载体的圆周表面移动。
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![METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE](/abs-image/US/2013/07/25/US20130190540A1/abs.jpg.150x150.jpg)
8.发明申请METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE 有权制备光学活性1-溴-1- [3,5-BIS（三氟甲基）苯基]乙烯的方法公开(公告)号：US20130190540A1
公开(公告)日：2013-07-25
申请号：US13811651
申请日：2011-07-21
IPC分类号： C07C17/04
CPC分类号： C07C17/04 , C07B53/00 , C07B2200/07 , C07C17/16 , C07C22/08
摘要： A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R1)(R2)(R3) (in the formula, R1, R2, and R3 independently represent a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxy group), or (c) a combination of N-bromosuccinimide and a dialkyl sulfide.
摘要翻译： 一种具有高光学纯度的光学活性1-溴-1- [3,5-双（三氟甲基） - 苯基]乙烷的制备方法，其包括将光学活性的1- [3,5-双（三氟甲基） 苯基]乙醇通过使用溴化剂，（a）卤化磷和溴化氢的组合，（b）1,2-二溴-1,1,2,2-四氯乙烷与有机磷化合物的组合 由通式（I）表示：P（R1）（R2）（R3）（在式中，R1，R2和R3独立地表示C6-10芳基，C6-10芳氧基，C1-10 烷基，C1-10烷氧基，C3-6环烷基或C3-6环烷氧基），或（c）N-溴代琥珀酰亚胺与二烷基硫醚的组合。
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9.发明授权
公开(公告)号：US6118253A
公开(公告)日：2000-09-12
申请号：US304414
申请日：1999-05-03
CPC分类号： H02J7/0063 , H02J7/0011 , H02J7/0031
摘要： A charge/discharge control circuit has a voltage detecting circuit for detecting at least one of an over-charge state, an over-discharge state and an over-current state of a battery, a control circuit for receiving an output signal of the detecting circuit and outputting a signal for controlling the charging and discharging of the battery, and an activating circuit connected to the control circuit for selectively activating the control circuit according to an output signal of the detecting circuit so as to limit the power consumption of the charge/discharge control circuit by operating the control circuit only when one of an over-charge state, an over-discharge state and an over-current state of the electric power source is detected.
摘要翻译： 充放电控制电路具有用于检测电池的过充电状态，过放电状态和过电流状态中的至少一种的电压检测电路，用于接收检测电路的输出信号的控制电路 并且输出用于控制电池的充电和放电的信号，以及连接到控制电路的激活电路，用于根据检测电路的输出信号选择性地启动控制电路，以便限制充电/放电的功耗 只有当检测到电源的过充电状态，过放电状态和过电流状态中的一个时，才通过操作控制电路来控制电路。
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公开(公告)号：US6092299A
公开(公告)日：2000-07-25
申请号：US146398
申请日：1998-09-03
申请人： Koichi Yamazaki , Shigeru Kasai
发明人： Koichi Yamazaki , Shigeru Kasai
IPC分类号： C23C14/24 , H01L21/00 , H01L21/205 , H01L21/26 , H01L21/285 , F26B13/30
CPC分类号： H01L21/67115
摘要： A present vacuum treating apparatus comprises a process chamber for subjecting an object to a predetermined process in a predetermined vacuum state, a stage located in the process chamber and on which the object is placed, a lamp unit provided at the lower side of the processing chamber and having a plurality of lamps as a light source and adapted to heat the object on the stage by a heat energy of light directed from these lamps to the stage for illumination, a rotation shaft connected to the lamp unit to rotate the lamp unit, a support body rotatably supporting the rotation shaft, and a thermo-module provided at a contacting area of the support body selective to the rotation shaft and, by absorbing heat on its rotation shaft side and dissipating heat on its support body side, transferring the heat on the lamp unit to the support body through the rotation shaft.
摘要翻译： 本真空处理装置包括处理室，用于使物体在预定的真空状态下进行预定的处理，位于处理室中的放置物体的台，设置在处理室的下侧的灯单元 并且具有多个灯作为光源并且适于通过从这些灯指向的光的热能来加热舞台上的物体以进行照明;连接到灯单元以旋转灯单元的旋转轴， 支撑体可旋转地支撑旋转轴，以及热模块，设置在支撑体的与旋转轴有选择性的接触区域处，并且通过在其旋转轴侧吸收热量并在其支撑体侧散发热量，将热量传递 灯单元通过旋转轴到支撑体。
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