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    Substituted nitrobenzophenone derivatives and a process for the preparation thereof
    4.
    发明授权
    Substituted nitrobenzophenone derivatives and a process for the preparation thereof 失效
    取代的硝基二苯甲酮衍生物及其制备方法

    公开(公告)号：US4064121A

    公开(公告)日：1977-12-20

    申请号：US603855

    申请日：1975-08-12

    申请人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szaboles Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

    发明人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szaboles Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

    IPC分类号： C07D295/10 ,  C07D225/02 ,  C07D211/14

    CPC分类号： C07D295/10

    摘要： New compounds of the general formula (I), ##STR1## wherein R.sub.1 and R.sub.2 each stand for a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form an optionally substituted heterocyclic group optionally containing a further oxygen or nitrogen hetero atom,But if R.sub.1 stands for methyl, R.sub.2 may only stand for a group other than methyl, are prepared by reacting a compound of the general formula ##STR2## wherein X stands for halogen, with a secondary amine of the general formula (III),r.sub.1 --nh--r.sub.2 (iii)wherein R.sub.1 and R.sub.2 each have the same meanings as defined above.The new compounds of the general formula (I), as well as their pharmaceutical acceptable acid addition salts or quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess antipyretic activity.

    摘要翻译： 通式（I）的新化合物，其中R 1和R 2各自表示饱和或不饱和的直链或支链烷基，芳烷基，饱和或不饱和环烷基或芳基 ，或R1和R2与相邻的氮原子一起可以形成任选地含有另外的氧或氮杂原子的任选取代的杂环基团，但是，R 1表示甲基，R 2可以仅代表甲基以外的基团，其通过使 通式（II）的化合物，其中X表示卤素，具有通式（III）的仲胺，R1-NH-R2（Ⅲ）其中R1和R2各自具有与上述相同的含义 。

    Piperidine derivatives and pharmaceutical compositions containing them
    7.
    发明授权
    Piperidine derivatives and pharmaceutical compositions containing them 失效
    哌啶衍生物和含有它们的药物组合物

    公开(公告)号：US4551465A

    公开(公告)日：1985-11-05

    申请号：US565902

    申请日：1983-12-27

    申请人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szabolcs Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Istvan Hajdu

    发明人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szabolcs Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Istvan Hajdu

    IPC分类号： C07D295/08 ,  A61K31/445 ,  A61P1/16 ,  A61P39/02 ,  A61P43/00 ,  C07D211/14 ,  C07D295/092 ,  C12N9/99

    CPC分类号： C07D295/088

    摘要： The invention relates to new piperidine derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms; andR.sub.2 is hydrogen or alkyl having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

    摘要翻译： 本发明涉及式（I）的新的哌啶衍生物：其中R 1是卤素，三卤代甲基，具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基; 并且R 2为氢或具有1至4个碳原子的烷基，及其酸加成盐和季铵盐。 根据本发明的另一方面，提供了这些化合物的制备方法。 式（I）的化合物具有药理活性。 特别地，它们抑制肝脏的微粒体单致原子酶系统。 含有它们作为活性成分的药物组合物也在本发明的范围内。