公开(公告)号：US20060211928A1

公开(公告)日：2006-09-21

申请号：US11417463

申请日：2006-05-03

申请人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

发明人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

摘要： A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

摘要翻译： 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US20070088205A1

公开(公告)日：2007-04-19

申请号：US11561380

申请日：2006-11-17

申请人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

发明人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

摘要： A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

摘要翻译： 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US20050148834A1

公开(公告)日：2005-07-07

申请号：US10972173

申请日：2004-10-22

申请人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

发明人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

IPC分类号： A61B5/00 ,  G01N20060101

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

摘要： A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

摘要翻译： 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US20050090750A1

公开(公告)日：2005-04-28

申请号：US10742110

申请日：2003-12-19

申请人： Marwood Ediger ,  Craig Gardner ,  Edward Hull

发明人： Marwood Ediger ,  Craig Gardner ,  Edward Hull

IPC分类号： A61B5/00 ,  A61B5/103 ,  A61B6/00

CPC分类号： A61B5/061 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/412 ,  A61B5/441 ,  A61B5/443

摘要： A method of determining disease state in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to Raman scattering of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating Raman emission with disease state to determine a disease state of the individual. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from Raman emission of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating Raman emission to disease state, including a variety of methods for generating such models. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of disease state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected Raman emission and disease state.

摘要翻译： 确定个体疾病状态的方法。 用激发光照射个体的组织的一部分，然后检测由组织响应于激发光的化学物质的拉曼散射而由组织发射的光。 检测到的光可以与将拉曼发射与疾病状态相关联的模型组合以确定个体的疾病状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测除了组织中的化学物质的拉曼发射以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将拉曼发射与疾病状态相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可以与拉曼光谱性质结合使用，有助于确定疾病状态。 本发明还包括适于执行该方法的装置，包括用于检测的拉曼发射和疾病状态的适当的光源，检测器和模型（例如，在计算机上实现的）。

公开(公告)号：US20080171924A9

公开(公告)日：2008-07-17

申请号：US10852415

申请日：2004-05-24

申请人： Trent Ridder ,  John Maynard ,  Russell Abbink ,  Robert Johnson ,  Edward Hull ,  Andrew Meigs ,  Alan Ross ,  Dashiell Birnkrant

发明人： Trent Ridder ,  John Maynard ,  Russell Abbink ,  Robert Johnson ,  Edward Hull ,  Andrew Meigs ,  Alan Ross ,  Dashiell Birnkrant

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14546

摘要： An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.

摘要翻译： 一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。 作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。

公开(公告)号：US20120078075A1

公开(公告)日：2012-03-29

申请号：US13311282

申请日：2011-12-05

申请人： John D. Maynard ,  Edward Hull

发明人： John D. Maynard ,  Edward Hull

IPC分类号： A61B5/145 ,  A61B6/00

CPC分类号： A61B5/443 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546

摘要： The present invention provides a method of determining disease state in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical in the tissue responsive to the excitation light is detected. The HbA1c or FPG measurement of the individual (or other secondary indication of disease state) can also be determined. A model combining the tissue fluorescence and one or more of the secondary indications can be used to determine the disease state of the individual. In some embodiments, the tissue fluorescence can be used as an initial screen, and the combination with secondary indications only made for those individuals for whom the fluorescence screen indicates an increased likelihood of disease.

摘要翻译： 本发明提供一种确定个体疾病状态的方法。 用激发光照射个体的组织的一部分，然后检测由于激发光对组织中的化学物质的荧光而由组织发出的光。 也可以确定个体的HbA1c或FPG测量（或疾病状态的其他二次指示）。 可以使用组合荧光和一种或多种次要适应症的模型来确定个体的疾病状态。 在一些实施方案中，组织荧光可以用作初始屏幕，并且与次要指示的组合仅针对荧光屏显示增加的疾病可能性的那些个体进行。