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    Methods and apparatus for effectuating a change in a neural-function of a patient
    5.
    发明授权
    Methods and apparatus for effectuating a change in a neural-function of a patient 有权
    用于实现患者神经功能变化的方法和装置

    公开(公告)号：US08050768B2

    公开(公告)日：2011-11-01

    申请号：US12343427

    申请日：2008-12-23

    申请人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    发明人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/375 ,  A61N1/3756

    摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by passing an electrical current through the electrode.

    摘要翻译： 本公开一般涉及用于实现患者的神经功能变化的方法和装置。 根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。 该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号而直接触发与刺激部位相关的神经反应，并通过传递电刺激部位电刺激皮质刺激部位 电流通过电极。

    Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
    6.
    发明授权
    Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 有权
    用于自动优化神经刺激器的刺激参数和电极配置的系统和方法

    公开(公告)号：US07945330B2

    公开(公告)日：2011-05-17

    申请号：US12244610

    申请日：2008-10-02

    申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

    发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

    摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

    摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到 治疗电极。

    METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT
    7.
    发明申请
    METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
    影响患者神经功能改变的方法和装置

    公开(公告)号：US20100131030A1

    公开(公告)日：2010-05-27

    申请号：US12698409

    申请日：2010-02-02

    申请人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    发明人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/375 ,  A61N1/3756

    摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.

    摘要翻译： 本公开一般涉及用于实现患者的神经功能变化的方法和装置。 根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。 该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号直接触发与刺激部位相关联的神经反应，并通过传递电刺激皮质刺激部位 电流通过电极。

    METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT
    8.
    发明申请
    METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 有权
    影响患者神经功能改变的方法和装置

    公开(公告)号：US20090319000A1

    公开(公告)日：2009-12-24

    申请号：US12343427

    申请日：2008-12-23

    申请人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    发明人： Andrew D. Firlik ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/375 ,  A61N1/3756

    摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.

    摘要翻译： 本公开一般涉及用于实现患者的神经功能变化的方法和装置。 根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。 该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号直接触发与刺激部位相关联的神经反应，并通过传递电刺激皮质刺激部位 电流通过电极。

    Methods and apparatus for effectuating a lasting change in a neural-function of a patient
    10.
    发明授权
    Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
    用于实现患者神经功能持续变化的方法和装置

    公开(公告)号：US08065012B2

    公开(公告)日：2011-11-22

    申请号：US11834650

    申请日：2007-08-06

    申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

    发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

    IPC分类号： A61N1/05

    CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

    摘要： Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.

    摘要翻译： 公开了几种用于施加颅内电刺激以治疗或增强患者的神经功能的装置和方法。 根据本发明，可以施用颅内电刺激来治疗脑损伤，脑疾病和/或脑疾病。 此外，颅内电刺激可以应用于正常的健康大脑，以增强神经功能或控制感觉功能。 大脑的电刺激部位位于发生神经可塑性，预期发生或未出现神经可塑性的区域。 预期颅内刺激通过应用亚阈值刺激来增加刺激部位神经元的静息膜电位，对预期的神经活动产生持久的作用。