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公开(公告)号：US20100135998A1
公开(公告)日：2010-06-03
申请号：US12527459
申请日：2008-02-26
申请人： Edward Paul Bowman , Daniel J. Cua , Robert A. Kastelein , Kathy Lynn Miller , Melanie A. Kleinschek , Kristian S. Bak-Jensen , Katia Boniface , Brent S. McKenzie , Rene de Waal Malefyt
发明人： Edward Paul Bowman , Daniel J. Cua , Robert A. Kastelein , Kathy Lynn Miller , Melanie A. Kleinschek , Kristian S. Bak-Jensen , Katia Boniface , Brent S. McKenzie , Rene de Waal Malefyt
CPC分类号： A61K39/3955 , A61K31/55 , A61K31/5575 , A61K38/1793 , A61K39/395 , A61K45/06 , C07K16/244 , C07K2317/76 , A61K2300/00
摘要： Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17 cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to alleviate signs and symptoms of an acute phase flare-up of the autoimmune disease, or cancer, and treatment with an antagonist of IL-23 is continued for a longer time to prevent recurrence of the acute event. Antagonists of PGE2 and CD161 are also disclosed for use in treatment of autoimmune, inflammatory and proliferative disorders.
摘要翻译： 提供了用于治疗诸如自身免疫性疾病或癌症的免疫疾病的方法和组合，涉及与抑制Th17细胞发育或维持的药物的联合治疗。 提供了治疗方案，其中施用促炎细胞因子的拮抗剂足以缓解自身免疫性疾病或癌症的急性期急性发作的体征和症状，并且用IL-23拮抗剂治疗是 持续较长时间，以防止急性事件复发。 还公开了PGE2和CD161的拮抗剂用于治疗自身免疫性，炎性和增殖性疾病。
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公开(公告)号：US20120156699A1
公开(公告)日：2012-06-21
申请号：US13405024
申请日：2012-02-24
申请人： Edward P. Bowman , Daniel J. Cua , Robert A. Kastelein , Kathy Lynn Miller , Melanie A. Kleinschek , Katia Boniface , Kristian S. Bak-Jensen , Brent S. McKenzie , Rene de Waal Malefyt
发明人： Edward P. Bowman , Daniel J. Cua , Robert A. Kastelein , Kathy Lynn Miller , Melanie A. Kleinschek , Katia Boniface , Kristian S. Bak-Jensen , Brent S. McKenzie , Rene de Waal Malefyt
IPC分类号： G01N33/566 , C07K16/46
CPC分类号： A61K39/3955 , A61K31/55 , A61K31/5575 , A61K38/1793 , A61K39/395 , A61K45/06 , C07K16/244 , C07K2317/76 , A61K2300/00
摘要： Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17 cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to alleviate signs and symptoms of an acute phase flare-up of the autoimmune disease, or cancer, and treatment with an antagonist of IL-23 is continued for a longer time to prevent recurrence of the acute event. Antagonists of PGE2 and CD161 are also disclosed for use in treatment of autoimmune, inflammatory and proliferative disorders.
摘要翻译： 提供了用于治疗诸如自身免疫性疾病或癌症的免疫疾病的方法和组合，涉及与抑制Th17细胞发育或维持的药物的联合治疗。 提供了治疗方案，其中施用促炎细胞因子的拮抗剂足以缓解自身免疫性疾病或癌症的急性期急性发作的体征和症状，并且用IL-23拮抗剂治疗是 持续较长时间，以防止急性事件复发。 还公开了PGE2和CD161的拮抗剂用于治疗自身免疫性，炎性和增殖性疾病。
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公开(公告)号：US08691953B2
公开(公告)日：2014-04-08
申请号：US13330902
申请日：2011-12-20
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号： C07K16/00
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US20120115164A1
公开(公告)日：2012-05-10
申请号：US13330902
申请日：2011-12-20
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US08080392B2
公开(公告)日：2011-12-20
申请号：US13025002
申请日：2011-02-10
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号： C12N15/09
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US20110177022A1
公开(公告)日：2011-07-21
申请号：US12984523
申请日：2011-01-04
申请人： Birgit Oppmann , Rene de Waal Malefyt , Donna M. Rennick , Robert A. Kastelein , Maria T. Wiekowski , Sergio A. Lira , Satwant K. Narula
发明人： Birgit Oppmann , Rene de Waal Malefyt , Donna M. Rennick , Robert A. Kastelein , Maria T. Wiekowski , Sergio A. Lira , Satwant K. Narula
IPC分类号： A61K38/20 , C07H21/00 , A61K31/56 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C07K16/24 , C12N5/071 , G01N33/53 , C12N5/0783 , A61P29/00 , A61P31/12
CPC分类号： C07K16/244 , A01K2217/05 , A61K38/00 , C07K14/54 , C07K14/5434 , C07K2317/32 , C07K2319/00 , C07K2319/02 , Y10S530/827
摘要： Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码哺乳动物细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US07906622B2
公开(公告)日：2011-03-15
申请号：US12414267
申请日：2009-03-30
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号： C07K14/52
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US07090847B1
公开(公告)日：2006-08-15
申请号：US09658699
申请日：2000-09-08
申请人： Birgit Oppmann , Rene De Waal Malefyt , Donna M. Rennick , Robert A. Kastelein , Maria T. Wiekowski , Sergio A. Lira , Satwant K. Narula
发明人： Birgit Oppmann , Rene De Waal Malefyt , Donna M. Rennick , Robert A. Kastelein , Maria T. Wiekowski , Sergio A. Lira , Satwant K. Narula
CPC分类号： C07K16/244 , A01K2217/05 , A61K38/00 , C07K14/54 , C07K14/5434 , C07K2317/32 , C07K2319/00 , C07K2319/02 , Y10S530/827
摘要： Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
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公开(公告)号：US07071308B2
公开(公告)日：2006-07-04
申请号：US10927228
申请日：2004-08-25
申请人： Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
发明人： Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
IPC分类号： C07K14/715 , C12N15/12
CPC分类号： C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要： Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译： 编码哺乳动物细胞因子受体的核酸，例如细胞因子IL-B50，纯化的蛋白质及其片段。 还提供了抗体，包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US07579440B2
公开(公告)日：2009-08-25
申请号：US10777790
申请日：2004-02-11
申请人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人： Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号： C07K14/00
CPC分类号： C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要： Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
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