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公开(公告)号：US09163618B2
公开(公告)日：2015-10-20
申请号：US13530931
申请日：2012-06-22
CPC分类号： F04B11/0075 , F04B23/06 , G01N30/32 , G01N30/34 , G01N2030/326 , Y10T137/0352 , Y10T137/7722 , G01N2030/342 , B01D15/40
摘要： An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.
摘要翻译： 描述了将标准的高效液相色谱（HPLC）流动路径转换到适用于超临界流体色谱（SFC）的流动路径的装置，系统和方法。 这种可逆技术应用于各种流动配置，包括二元，高压溶剂混合系统和四级，低压溶剂混合系统，比常规操作或自动化。 该技术通常应用于超临界流体色谱和高压液相色谱领域，但是本领域技术人员将发现对于任何流动系统都将发挥效用，其中加压组分必须周期性地施加到流动流的两端并从其中移除 自动化方式。
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公开(公告)号：US20130180404A1
公开(公告)日：2013-07-18
申请号：US13825128
申请日：2011-09-20
IPC分类号： B01D19/00
CPC分类号： B01D19/0036 , B01D15/10 , B01D15/40 , B01D19/0057 , B01D19/0063
摘要： An apparatus and process to effectively create an active drain for high and low pressure gas-liquid separator. The invention accomplishes a deterministic drainage rate of variable volume and viscosity liquid fractions from the separator. The mechanisms and methods thereof create a flow path from the separator that dramatically favors controlled liquid flow over a wide range of flow rates and viscosities while restricting gas flow. The invention is a superior method of drainage over conventional systems that employ pressure, vacuum, isolation valves and/or passive flow restrictors to achieve drainage of the separators. The embodiments are primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE). An advantage of one embodiment allows the economical conversion of typical HPLC systems to state of-the-art supercritical fluid chromatography (SFC) systems with minimal modification to system components.
摘要翻译： 一种有效地创建高压和低压气液分离器的主动排水的装置和方法。 本发明实现了来自分离器的可变体积和粘度液体馏分的确定性排水速率。 其机制和方法从分离器产生流动路径，其在限制气体流动的同时显着地有利于在宽范围的流速和粘度下控制的液体流动。 本发明是采用压力，真空，隔离阀和/或被动流量限制器以实现分离器排水的常规系统的优选排水方法。 实施方案主要涉及制备型超临界流体色谱（SFC）和超临界流体萃取（SFE）领域。 一个实施方案的优点允许将典型的HPLC系统经济地转化为现有技术的超临界流体色谱（SFC）系统，同时对系统组分进行最小的修改。
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3.发明授权Compressible fluid pumping system for dynamically compensating compressible fluids over large pressure ranges 有权可压缩流体泵送系统，用于在大压力范围内动态补偿可压缩流体公开(公告)号：US08215922B2
公开(公告)日：2012-07-10
申请号：US12230875
申请日：2008-09-05
申请人： Terry A. Berger , Kimber D. Fogelman , Edwin E. Wikfors , L. Thomson Staats, III , Samuel O. Colgate , Michael A. Casale
发明人： Terry A. Berger , Kimber D. Fogelman , Edwin E. Wikfors , L. Thomson Staats, III , Samuel O. Colgate , Michael A. Casale
CPC分类号： G01N30/32 , F04B23/06 , G01N30/34 , G01N2030/326 , Y10T29/49716 , Y10T29/49826 , Y10T137/86139 , B01D15/40
摘要： An invention is claimed that enables the pumping of compressible fluids at high pressures when an accurate flow is desired. Two pressure sources, for example pumps plumbed in series, separate thermodynamic work, such as pressurization, at the first pressure source from a volumetric or matter metering function in the second pressure source. One example is a flowstream delivery for a chemical instrumentation system that is manufactured from relatively unsophisticated pumps yet delivers precise flows with low pulsation (
摘要翻译： 本发明要求能够在需要精确流动时在高压下泵送可压缩流体。 两个压力源，例如串联的泵，在第二压力源中的第一压力源上的体积或物质计量功能分离热力学工作，例如加压。 一个例子是用于化学仪器系统的流动输送，其由相对不成熟的泵制造，但是在超过100巴的压力下，以低脉动（<1％）提供精确流量。 一个实施方案的优点允许将典型的HPLC系统经济地转化为现有技术的超临界流体色谱（SFC）系统，同时对系统组分进行最小的修改。
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公开(公告)号：US09114330B2
公开(公告)日：2015-08-25
申请号：US13825128
申请日：2011-09-20
CPC分类号： B01D19/0036 , B01D15/10 , B01D15/40 , B01D19/0057 , B01D19/0063
摘要： A device includes a gas-liquid separator that receives and separates a biphasic pressurized flow stream and delivers flow to at least one exit port enriched in vapor phase composition and at least one exit port enriched in liquid phase composition. The device further includes a low restriction inlet conduit in communication with the separator exit port enriched in liquid phase composition, and a positive displacement pump having an inlet port in communication with the inlet conduit to receive flow from the gas-liquid separator and an outlet port in communication with an outlet conduit.
摘要翻译： 一种装置包括气 - 液分离器，其接收和分离两相加压流，并将流量输送至至少一个富含气相组成的出口和至少一个富含液相组成的出口。 该装置还包括与富含液相组合物的分离器出口连通的低限制入口导管，以及容积式泵，其具有与入口导管连通的入口端口，以接收来自气液分离器的流动和出口端口 与出口导管连通。
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公开(公告)号：US20100040483A1
公开(公告)日：2010-02-18
申请号：US12230875
申请日：2008-09-05
申请人： Terry A. Berger , Kimber D. Fogelman , Edwin E. Wikfors , L. Thomson Staats, III , Samuel O. Colgate , Michael A. Casale
发明人： Terry A. Berger , Kimber D. Fogelman , Edwin E. Wikfors , L. Thomson Staats, III , Samuel O. Colgate , Michael A. Casale
CPC分类号： G01N30/32 , F04B23/06 , G01N30/34 , G01N2030/326 , Y10T29/49716 , Y10T29/49826 , Y10T137/86139 , B01D15/40
摘要： An invention is claimed that enables the pumping of compressible fluids at high pressures when an accurate flow is desired. Two pressure sources, for example pumps plumbed in series, separate thermodynamic work, such as pressurization, at the first pressure source from a volumetric or matter metering function in the second pressure source. One example is a flowstream delivery for a chemical instrumentation system that is manufactured from relatively unsophisticated pumps yet delivers precise flows with low pulsation (
摘要翻译： 本发明要求能够在需要精确流动时在高压下泵送可压缩流体。 两个压力源，例如串联的泵，在第二压力源中的第一压力源上的体积或物质计量功能分离热力学工作，例如加压。 一个例子是用于化学仪器系统的流动输送，其由相对不成熟的泵制造，但是在超过100巴的压力下，以低脉动（<1％）提供精确流量。 一个实施方案的优点允许将典型的HPLC系统经济地转化为现有技术的超临界流体色谱（SFC）系统，同时对系统组分进行最小的修改。
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公开(公告)号：US07670487B2
公开(公告)日：2010-03-02
申请号：US11490498
申请日：2006-07-21
IPC分类号： B01D15/08
CPC分类号： G05D16/202 , B01D15/163 , G01N30/32 , Y10T137/0396 , Y10T137/2278
摘要： A depressurization process for a packed separation column is provided where the column system experiences a rapid and/or severe drop in pressure that could potentially damage column components. The process provides a safe de-pressurization of the column on the outlet side by decreasing the outlet pressure in controlled steps while allowing the inlet pressure of the column time to lower after each decreased step.
摘要翻译： 提供了一种用于填充分离塔的减压方法，其中塔系统经历可能损坏塔组分的快速和/或严重的压力下降。 该方法通过在受控的步骤中降低出口压力，同时允许柱子的入口压力在每个降低的步骤之后降低，从而在出口侧对柱进行安全的降压。
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公开(公告)号：US08877051B2
公开(公告)日：2014-11-04
申请号：US11490499
申请日：2006-07-21
申请人： Kimber D. Fogelman , Edwin E. Wikfors , Rui Chen
发明人： Kimber D. Fogelman , Edwin E. Wikfors , Rui Chen
IPC分类号： G01N30/82
CPC分类号： G01N30/82
摘要： A system and process for chromatography that uses a chromatography column to separate components from a sample received into the column in a mobile phase flowstream and places a second chromatography column between a detector and a collection system that compensates the timing of fraction collection for a delay caused by processing the collection signals generated by the detector. The device and process of the preferred and alternative embodiments add a delay into the flowstream of a chromatographic system, such as LC, HPLC, and SFC. Sample fractions are collected from sample component concentration peaks based upon the chromatographic elution of the sample components.
摘要翻译： 用于色谱柱的系统和方法，其使用色谱柱将来自在流动相流中流入柱的样品中分离组分，并将第二色谱柱置于检测器和收集系统之间，以补偿引起的延迟的馏分收集时间 通过处理由检测器产生的收集信号。 优选和替代实施方案的装置和方法对色谱系统的流动流如LC，HPLC和SFC增加延迟。 基于样品组分的色谱洗脱，从样品组分浓度峰中收集样品级分。
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公开(公告)号：US20080021663A1
公开(公告)日：2008-01-24
申请号：US11490498
申请日：2006-07-21
CPC分类号： G05D16/202 , B01D15/163 , G01N30/32 , Y10T137/0396 , Y10T137/2278
摘要： A depressurization process for a packed separation column is provided where the column system experiences a rapid and/or severe drop in pressure that could potentially damage column components. The process provides a safe de-pressurization of the column on the outlet side by decreasing the outlet pressure in controlled steps while allowing the inlet pressure of the column time to lower after each decreased step.
摘要翻译： 提供了一种用于填充分离塔的减压方法，其中塔系统经历可能损坏塔组分的快速和/或严重的压力下降。 该方法通过在受控的步骤中降低出口压力，同时允许柱子的入口压力在每个降低的步骤之后降低，从而在出口侧对柱进行安全的降压。
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公开(公告)号：US20090050568A1
公开(公告)日：2009-02-26
申请号：US11490499
申请日：2006-07-21
申请人： Kimber D. Fogelman , Edwin E. Wikfors , Rui Chen
发明人： Kimber D. Fogelman , Edwin E. Wikfors , Rui Chen
IPC分类号： B01D15/18
CPC分类号： G01N30/82
摘要： A system and process for chromatography that uses a chromatography column to separate components from a sample received into the column in a mobile phase flowstream and places a second chromatography column between a detector and a collection system that compensates the timing of fraction collection for a delay caused by processing the collection signals generated by the detector. The device and process of the preferred and alternative embodiments add a delay into the flowstream of a chromatographic system, such as LC, HPLC, and SFC. Sample fractions are collected from sample component concentration peaks based upon the chromatographic elution of the sample components.
摘要翻译： 用于色谱柱的系统和方法，其使用色谱柱将来自在流动相流中流入柱的样品中分离组分，并将第二色谱柱置于检测器和收集系统之间，以补偿引起的延迟的馏分收集时间 通过处理由检测器产生的收集信号。 优选和替代实施方案的装置和方法对色谱系统的流动流如LC，HPLC和SFC增加延迟。 基于样品组分的色谱洗脱，从样品组分浓度峰中收集样品级分。
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公开(公告)号：US5905192A
公开(公告)日：1999-05-18
申请号：US899420
申请日：1997-07-23
CPC分类号： G01N30/8624 , G01N2030/625 , G01N30/8631
摘要： Method and apparatus are provided for peak identification of sample peaks in a chromatogram, wherein at least one group of standard peaks in standard peak series is matched to at least one group of sample peaks in a sample peak series so as to perform proper identification of the sample peaks in the sample peak group. In a preferred method, a succession of retention time windows are determined according to the characteristic retention times of the standard peaks and according to steps for determining shift, stretch, and distort parameters. The retention time windows are located with respect to the sample peak series and in accordance with the shift, stretch, and distort parameters so as to capture only certain ones of the sample peaks in the sample peak series. The shift, stretch, and distort parameters are used to position the retention time windows for improved matching of the standard peaks in the standard peak group to the captured sample peaks.
摘要翻译： 提供方法和装置用于在色谱图中峰值鉴定样品峰，其中标准峰序列中的至少一组标准峰与样品峰序列中的至少一组样品峰匹配，以便正确鉴定 样品峰组中的样品峰。 在优选的方法中，根据标准峰的特征保留时间和根据用于确定移位，拉伸和失真参数的步骤来确定连续的保留时间窗口。 保留时间窗口相对于采样峰值系列并根据移位，拉伸和失真参数定位，以便仅捕获样本峰值系列中某些样本峰。 移位，拉伸和扭曲参数用于定位保留时间窗口，以改善标准峰组中的标准峰与捕获的样本峰的匹配。
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