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公开(公告)号：US4946941A
公开(公告)日：1990-08-07
申请号：US3252
申请日：1987-01-14
申请人： Eiji Kondo , Naoki Tsuji , Koichi Matsumoto , Yoshimi Kawamura , Tadashi Yoshida , Shinzo Matsuura
发明人： Eiji Kondo , Naoki Tsuji , Koichi Matsumoto , Yoshimi Kawamura , Tadashi Yoshida , Shinzo Matsuura
摘要： The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.
摘要翻译： 下式的化合物：其中R是H，其中X是NH 2，Y是CH 3; 或X为OH且Y为H及其药学上可接受的盐。 这些化合物对革兰氏阳性细菌，特别是耐甲氧西林细菌具有很强的活性。
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公开(公告)号：US5071749A
公开(公告)日：1991-12-10
申请号：US174449
申请日：1988-03-25
申请人： Eiji Kondo , Yoshimi Kawamura , Naoki Tsuji , Koichi Matsumoto , Masaaki Kobayashi , Toshiyuki Kamigauchi , Yoshiyuki Hayashi , Takao Konishi
发明人： Eiji Kondo , Yoshimi Kawamura , Naoki Tsuji , Koichi Matsumoto , Masaaki Kobayashi , Toshiyuki Kamigauchi , Yoshiyuki Hayashi , Takao Konishi
CPC分类号： C07K9/008
摘要： Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria, and stimulate growth of animals.
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公开(公告)号：US4292241A
公开(公告)日：1981-09-29
申请号：US115278
申请日：1980-01-25
申请人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
发明人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04 , C12P17/18 , C12R1/465
CPC分类号： C07D477/20 , C12P17/184 , C12R1/465
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新型抗生素PA-31088-IV可用作药物和用于抑制革兰氏阳性和革兰氏阴性致病微生物生长的兽药及其制备方法，其特征在于 培养链霉菌（Toreptomyces tokunonensis sp。） nov。 在合适的培养基中回收PA-31088-IV。
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公开(公告)号：US4371617A
公开(公告)日：1983-02-01
申请号：US244857
申请日：1981-03-18
申请人： Kentaro Tanaka , Naoki Tsuji , Eiji Kondo , Yoshimi Kawamura
发明人： Kentaro Tanaka , Naoki Tsuji , Eiji Kondo , Yoshimi Kawamura
CPC分类号： C12R1/465 , C12P17/184 , Y10S435/886
摘要： A new process for preparing thienamycin, a known antibiotic useful as a medicament and veterinary drug, characterized by cultivating Streptomyces penemifaciens sp. nov. in a suitable medium and recovering thienamycin from the fermentation broth.
摘要翻译： 一种制备硫辛霉素的新方法，已知的可用作药物和兽药的抗生素，其特征在于培养长链短杆菌（Streptomyces penemifaciens sp。 nov。 在合适的培养基中并从发酵液中回收噻吩霉素。
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公开(公告)号：US4448723A
公开(公告)日：1984-05-15
申请号：US432102
申请日：1982-09-29
申请人： Kentaro Tanaka , Eiji Kondo , Mikao Mayama , Kouichi Matsumoto , Yoshimi Kawamura , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Mikao Mayama , Kouichi Matsumoto , Yoshimi Kawamura , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P1/06 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号： C07D477/20 , C12P17/184
摘要： New antibiotics having .beta.-lactamase inhibitory activity, PA-41746-B and C of the formula ##STR1## wherein R is carboxymethylsulfinyl (PA-41746-B) or formylsulfinyl (PA-41746-C) and the pharmaceutically acceptable salts being useful as a medicament, a veterinary drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces pluracidomyceticus in a suitable medium and isolating PA-41746-B and/or PA-41746-C from the culture broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新抗生素，式为IMA IMA的PA-41746-B和C，其中R为羧甲基亚磺酰基（PA-41746-B）或甲酰亚磺酰基（PA-41746-C），其药学上可接受的盐可用作 用于抑制革兰氏阳性和革兰氏阴性病原微生物生长的药物，兽药和消毒剂及其制备方法，其特征在于在合适的培养基中培养链霉菌（Streptomyces pluracidomyceticus）并分离PA-41746-B和/ 或来自培养液的PA-41746-C。
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公开(公告)号：US4456686A
公开(公告)日：1984-06-26
申请号：US421580
申请日：1982-09-22
申请人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465
CPC分类号： C07D477/20 , C12P17/184 , C12R1/465 , Y10S435/886
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.1 of the formula: ##STR1## being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and recovering PA-39504-X.sub.1 from the cultured broth.
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公开(公告)号：US4387052A
公开(公告)日：1983-06-07
申请号：US286757
申请日：1981-07-27
申请人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号： C07D477/20 , C12P17/184
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.3 of the formula: ##STR1## and the pharmaceutically acceptable slats being useful as a drug, a animal drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and isolating PA-39504-X.sub.3 from the cultured broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新型抗生素，下式的PA-39504-X3：药物可接受的片剂可用作药物，动物药物和用于抑制革兰氏阳性和革兰氏阳性菌生长的消毒剂， 阴性致病微生物及其制备方法，其特征在于在合适的培养基中培养棒状链霉菌PA-39504或链霉菌Tokunonensis PA-31088，并从培养液中分离PA-39504-X3。
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公开(公告)号：US4647408A
公开(公告)日：1987-03-03
申请号：US574362
申请日：1984-01-27
申请人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Naoki Tsuji
IPC分类号： C07D477/20 , C12P17/18 , C07D487/04 , A61K31/40
CPC分类号： C12P17/184 , C07D477/20
摘要： Antibiotics PA-41746-A.sub.2, PA-41746-E and PA-41746-F produced by fermentation of Streptomyces pluracidomyceticus on a conventional culture medium, having .beta.-lactamase inhibitory activities and excellent antimicrobial activities, and useful as drugs for treatment of infections in humans or animals, or as disinfectants.
摘要翻译： 抗生素PA-41746-A2，PA-41746-E和PA-41746-F，其通过在常规培养基上发酵链霉菌（Plrepacidomyceticus）产生，具有β-内酰胺酶抑制活性和优异的抗微生物活性，并且可用作治疗感染的药物 人或动物，或消毒剂。
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公开(公告)号：US4362665A
公开(公告)日：1982-12-07
申请号：US211715
申请日：1980-12-01
申请人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Kouichi Matsumoto , Jun'ichi Shoji , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号： C07D477/20 , C12P17/184 , C12R1/465 , Y10S435/886
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.1 of the formula: ##STR1## being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and recovering PA-39504-X.sub.1 from the cultured broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新型抗生素，下式的PA-39504-X1可用作药物和用于抑制革兰氏阳性和革兰氏阴性病原微生物生长的兽药，以及制备方法 其特征在于在合适的培养基中培养链霉菌PA-39504或链霉菌Tokunonensis PA-31088，并从培养液中回收PA-39504-X1。
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公开(公告)号：US07016773B2
公开(公告)日：2006-03-21
申请号：US10897076
申请日：2004-07-23
申请人： Shigetaka Kuroda , Takashi Kamimura , Hiroshi Murakami , Akihito Ohtsu , Kiyoshi Asami , Naoki Tsuji
发明人： Shigetaka Kuroda , Takashi Kamimura , Hiroshi Murakami , Akihito Ohtsu , Kiyoshi Asami , Naoki Tsuji
CPC分类号： B60W20/15 , B60K6/485 , B60K6/543 , B60L11/14 , B60W10/06 , B60W10/08 , B60W20/00 , F01L1/181 , F01L13/0036 , F01L2105/00 , F01L2800/00 , F02D13/0234 , F02D13/0257 , F02D13/0269 , F02D2041/001 , F02D2200/0625 , Y02T10/142 , Y02T10/18 , Y02T10/52 , Y02T10/56 , Y02T10/6226 , Y02T10/6286 , Y02T10/70 , Y02T10/7077
摘要： A control system for a hybrid vehicle, which enables the hybrid vehicle to optimally selectively use driven modes to attain excellent fuel economy and thereby make it possible to improve fuel economy. The hybrid vehicle is operated in an engine-driven mode or a motor-driven mode, and recovers electric energy for driving an electric motor, using the output from the engine. The control system calculates a driving fuel consumption amount of the engine required for driving the hybrid vehicle in the engine-driven mode and a recovering fuel consumption amount of the engine required for recovering electric energy to be consumed when the hybrid vehicle is driven in the motor-driven mode, and sets the driven mode to the motor-driven mode when the recovering fuel consumption amount is smaller than the driving fuel consumption amount, and to the engine-driven mode when the former is larger than the latter.
摘要翻译： 一种用于混合动力车辆的控制系统，其使得混合动力车辆能够最佳地选择性地使用驱动模式以获得优异的燃料经济性，从而可以提高燃料经济性。 混合动力车辆以发动机驱动模式或电动机驱动模式操作，并使用发动机的输出来恢复用于驱动电动机的电能。 控制系统计算在发动机驱动模式下驱动混合动力车辆所需的发动机的驱动燃料消耗量以及当在电动机中驱动混合动力车辆时恢复要消耗的电能所需的发动机的恢复燃料消耗量 并且当恢复燃料消耗量小于驱动燃料消耗量时，将驱动模式设定为电动机模式，并且当前者大于后者时，将其设定为发动机驱动模式。
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