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公开(公告)号：US4292241A
公开(公告)日：1981-09-29
申请号：US115278
申请日：1980-01-25
申请人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
发明人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04 , C12P17/18 , C12R1/465
CPC分类号： C07D477/20 , C12P17/184 , C12R1/465
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新型抗生素PA-31088-IV可用作药物和用于抑制革兰氏阳性和革兰氏阴性致病微生物生长的兽药及其制备方法，其特征在于 培养链霉菌（Toreptomyces tokunonensis sp。） nov。 在合适的培养基中回收PA-31088-IV。
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公开(公告)号：US5171836A
公开(公告)日：1992-12-15
申请号：US545565
申请日：1990-06-29
IPC分类号： C12N1/20 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/06 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/38
CPC分类号： C07K7/06
摘要： This invention provides a novel compound of the formula: ##STR1## wherein X is L-HyPro or L-Pro, R is --CH.sub.3 or --CH(CH.sub.3).sub.2, and n is an integer from 9 to 12, or its salt, a process for producing the compound which comprises cultivating a microorganism which belongs to the genus Pseudomonas and produces the compound in a medium and recovering the compound from the medium and a biologically pure culture of Pseudomas sp. PB-6250 producing the compound.
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公开(公告)号：US4950686A
公开(公告)日：1990-08-21
申请号：US86583
申请日：1987-08-18
申请人： Eiji Kondo , Yoshiyuki Hayashi , Takao Konishi , Teruo Hattori , Junichi Shoji
发明人： Eiji Kondo , Yoshiyuki Hayashi , Takao Konishi , Teruo Hattori , Junichi Shoji
IPC分类号： C07C49/753 , A61K31/12 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/26 , A61K31/335 , A61K31/34 , A61K31/343 , A61K31/357 , A61P31/04 , A61P33/02 , C07C45/00 , C07C49/717 , C07C51/00 , C07C59/125 , C07C67/00 , C07C69/28 , C07C69/67 , C07C69/68 , C07C301/00 , C07C309/72 , C07C325/00 , C07C331/06 , C07D307/89 , C07D317/22 , C07F15/02 , C07F15/04 , C07F15/06
CPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/26 , A61K31/335 , A61K31/34
摘要： An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula: ##STR1## (wherein R.sub.1 is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy) and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.
摘要翻译： 一种抗支原体药，其包含由下式表示的托普洛芬及其衍生物：其中R1是羟基，脂族酰氧基，芳基酰氧基，芳磺酰氧基，羧基烷氧基或其酯，苯甲酰基烷氧基，烯氧基，1,3-二氢-3-氧代 -1-异苯并呋喃基氧基，（2-氧代-5-甲基-1,3-间二氧杂环戊烯-4-基）甲氧基或硫氰酸酯，R 2为氢，卤素，羟基，烷基或烷氧基）及其盐作为活性成分， 特别是在体外和体内抗泰乐菌素抗性支原体的有效活性，并且有效地用于治疗由此引起的疾病。
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公开(公告)号：US5045458A
公开(公告)日：1991-09-03
申请号：US424366
申请日：1989-10-19
IPC分类号： C07D307/34 , C12P17/04
CPC分类号： C07D307/34 , C12P17/04 , Y10S435/822
摘要： A compound of the formula (I): ##STR1## wherein R is: (CH.sub.2).sub.8 CH.sub.3,(CH.sub.2).sub.3 CH.sup.(cis) CH(CH.sub.2).sub.5 CH.sub.3,(CH.sub.2).sub.10 CH.sub.3, or(CH.sub.2).sub.4 CH.sup.(cis) CH(CH.sub.2).sub.6 CH.sub.3.or salt thereof, and a microorganism producing the compound are provided.
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