Patent search ap:("Eisai R&D Management Co. Page Ltd.") AND inv:"Yoko Ito"

1.

发明申请
CRYSTALS OF PYRANODIPYRIDINE COMPOUND 有权

公开(公告)号：US20210323972A1

公开(公告)日：2021-10-21

申请号：US16605424

申请日：2018-05-07

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida , Yoko Ito , Masaaki Matsuda

IPC: C07D491/147

Abstract: The present invention provides a crystal of the compound represented by formula (I) having applicability as a drug substance of pharmaceuticals.

2.

发明授权
Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide 有权

公开(公告)号：US10259817B2

公开(公告)日：2019-04-16

申请号：US15577858

申请日：2016-06-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida , Yoko Ito

IPC: C07D487/04 , A61K31/53 , A61P35/00

Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

3.

发明申请
Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide 审中-公开

公开(公告)号：US20180141950A1

公开(公告)日：2018-05-24

申请号：US15577858

申请日：2016-06-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida , Yoko Ito

IPC: C07D487/04 , A61K31/53 , A61P35/00

CPC classification number: C07D487/04 , A61K31/53 , A61P35/00 , C07B2200/13

Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl} methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

4.

发明申请
CRYSTAL OF SUBSTITUTED PIPERIDINE COMPOUND, SALTS OF SUBSTITUTED PIPERIDINE COMPOUND, AND CRYSTALS THEREOF 有权

公开(公告)号：US20250051322A1

公开(公告)日：2025-02-13

申请号：US18722917

申请日：2023-01-12

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida , Yoko Ito , So Yasui , Takashi Fukuyama , Nobuaki Sato , Taro Asaba

IPC: C07D451/02 , A61K31/506

Abstract: Crystals of compounds represented by formula (I) having potential as drug substances for pharmaceuticals, as well as salts of compounds represented by formula (I) and their crystals.

5.

发明授权
Salts of compounds and crystals thereof 有权

公开(公告)号：US11691990B2

公开(公告)日：2023-07-04

申请号：US17058406

申请日：2019-08-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Jun Niijima , Hirofumi Kuroda , So Yasui , Yoko Ito , Ikuo Kushida

IPC: C07D519/00 , A61P35/00 , C07F9/6587 , C07H21/00 , A61K31/7084

CPC classification number: C07D519/00 , C07B2200/13

Abstract: The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.

6.

发明授权
Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide 有权

公开(公告)号：US10221183B2

公开(公告)日：2019-03-05

申请号：US15577858

申请日：2016-06-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida , Yoko Ito

IPC: C07D487/04 , A61K31/53 , A61P35/00

Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

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