公开(公告)号：US20190185432A1

公开(公告)日：2019-06-20

申请号：US16229805

申请日：2018-12-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48

CPC classification number: C07D215/48 ,  A61K31/47 ,  A61P35/00

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US10822307B2

公开(公告)日：2020-11-03

申请号：US16559293

申请日：2019-09-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48 ,  A61P35/00 ,  A61K31/47

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US10407393B2

公开(公告)日：2019-09-10

申请号：US16229805

申请日：2018-12-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48 ,  A61K31/47

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US10259791B2

公开(公告)日：2019-04-16

申请号：US15503108

申请日：2015-08-26

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48 ,  A61K31/47

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US20170233344A1

公开(公告)日：2017-08-17

申请号：US15503108

申请日：2015-08-26

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48

CPC classification number: C07D215/48 ,  A61K31/47

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US11691990B2

公开(公告)日：2023-07-04

申请号：US17058406

申请日：2019-08-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Jun Niijima ,  Hirofumi Kuroda ,  So Yasui ,  Yoko Ito ,  Ikuo Kushida

IPC: C07D519/00 ,  A61P35/00 ,  C07F9/6587 ,  C07H21/00 ,  A61K31/7084

CPC classification number: C07D519/00 ,  C07B2200/13

Abstract: The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.

公开(公告)号：US11186547B2

公开(公告)日：2021-11-30

申请号：US17022675

申请日：2020-09-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48 ,  A61P35/00 ,  A61K31/47

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

公开(公告)号：US20190389804A1

公开(公告)日：2019-12-26

申请号：US16559293

申请日：2019-09-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taiju Nakamura ,  Taichi Abe ,  Yusuke Miyashita ,  Hirofumi Kuroda ,  Yusuke Ayata ,  Atsushi Akao

IPC: C07D215/48

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.