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公开(公告)号：US20210255191A1
公开(公告)日：2021-08-19
申请号：US17163993
申请日：2021-02-01
发明人： Daiki HARA , Takafumi Motoki , Yuji Kazuta , Yoshihiko Norimine , Hiroyuki Amino , Masatoshi Suganuma , Shingo Fujiyama , Kazuto Yamashita , Masaya Okada , Yoichi Nishikawa , Shigeki Iwanaga
摘要： Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.
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公开(公告)号：US09610262B2
公开(公告)日：2017-04-04
申请号：US15102046
申请日：2014-12-17
IPC分类号： A61K31/165 , A61K31/18
CPC分类号： A61K31/165 , A61K31/18
摘要： The present invention is directed to a method of treating pain comprising the administering the following 1-indansulfamide compounds: N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (−)-N-(7-chloro-2,2,5-trifluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, N-[(1S)-2,2-difluoro-7-methyl-2,3-dihydro-1H-inden-1-yl]sulfamide, and N-[(1S)-2,2,5-trifluoro-7-methyl-2,3-dihydro-1H-inden-1-yl]sulfamide.
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3.发明授权Methods and compounds useful in the synthesis of orexin-2 receptor antagonists 有权用于合成食欲肽-2受体拮抗剂的方法和化合物公开(公告)号：US09416109B2
公开(公告)日：2016-08-16
申请号：US14379063
申请日：2013-02-14
发明人： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Jaemoon Lee , Huiming Zhang , Taro Terauchi , Ayumi Takemura , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Yuji Kazuta
IPC分类号： C07D239/34 , C07C69/16 , C07C309/66 , C12P7/22 , C07C309/73 , C07D401/12 , C07C303/28 , C07C29/147
CPC分类号： C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50
摘要： The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
摘要翻译： 本公开提供了可用于制备可用作食欲素-2受体拮抗剂的化合物的化合物和方法。
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4.发明申请THERAPEUTIC AND/OR PREVENTIVE AGENT COMPRISING 1-INDANSULFAMIDE DERIVATIVE FOR PAIN 有权包含1-INDANSULFAMIDE衍生物用于疼痛的治疗和/或预防剂公开(公告)号：US20160303058A1
公开(公告)日：2016-10-20
申请号：US15102046
申请日：2014-12-17
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K31/18
摘要： A medicine comprising a 1-indansulfamides compound such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, or N-[(1S)-2,2-difluoro-7-methyl-2,3-dihydro-1H-indene-1-yl]sulfamide or a pharmaceutically acceptable salt thereof, has an analgesic effects in the mouse hot-plate test and rat constriction nerve injury model and thus holds promise as a therapeutic agent for acute and chronic pain.
摘要翻译： 包含诸如N - [（1S）-2,2,5,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺的1-二氢化茚磺酰胺化合物或N - [（1S） -2,2-二氟-7-甲基-2,3-二氢-1H-茚-1-基]磺酰胺或其药学上可接受的盐在小鼠热板试验和大鼠收缩神经损伤模型中具有镇痛作用 因此作为急性和慢性疼痛的治疗剂具有希望。
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公开(公告)号：US20140371319A1
公开(公告)日：2014-12-18
申请号：US14370633
申请日：2013-06-17
发明人： Yuji Kazuta , Toru Watanabe , Keiichi Sorimachi , Minako Saito , Yoichi Kita , Toshiaki Tanaka , Hiroyuki Higashiyama , Takahisa Hanada , Tetsuyuki Teramoto , Takashi Kosasa , Yukio Ishikawa
IPC分类号： C07C307/08
CPC分类号： C07C307/08 , A61K31/18 , C07C309/00 , C07C2602/08
摘要： Novel indansulfamide derivatives or a pharmaceutically acceptable salt thereof such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (+)-N-(2,2,4,6,7-pentafluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, have an action of improving Seizure Severity Index (Score) in mice kindling model. Thus the compounds or the salt thereof are expected as a drug for treating epilepsy.
摘要翻译： 新型的茚满磺酰胺衍生物或其药学上可接受的盐，例如N - [（1S）-2,2,5,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺，N - [（1S） -2,2,4,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺，（+） - N-（2,2,4,6,7-五氟-2,3- 二氢-1H-茚-1-基）磺酰胺，具有改善小鼠诱发模型中的发作严重程度指数（Score）的作用。 因此，期望化合物或其盐作为治疗癫痫的药物。
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公开(公告)号：US09018260B2
公开(公告)日：2015-04-28
申请号：US14370633
申请日：2013-06-17
发明人： Yuji Kazuta , Toru Watanabe , Keiichi Sorimachi , Minako Saito , Yoichi Kita , Toshiaki Tanaka , Hiroyuki Higashiyama , Takahisa Hanada , Tetsuyuki Teramoto , Takashi Kosasa , Yukio Ishikawa
IPC分类号： A61K31/18 , C07C311/00 , C07C307/08 , C07C309/00
CPC分类号： C07C307/08 , A61K31/18 , C07C309/00 , C07C2602/08
摘要： Novel indansulfamide derivatives or a pharmaceutically acceptable salt thereof such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (+)-N-(2,2,4,6,7-pentafluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, have an action of improving Seizure Severity Index (Score) in mice kindling model. Thus the compounds or the salt thereof are expected as a drug for treating epilepsy.
摘要翻译： 新型的茚满磺酰胺衍生物或其药学上可接受的盐，例如N - [（1S）-2,2,5,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺，N - [（1S） -2,2,4,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺，（+） - N-（2,2,4,6,7-五氟-2,3- 二氢-1H-茚-1-基）磺酰胺，具有改善小鼠诱发模型中的发作严重程度指数（Score）的作用。 因此，期望化合物或其盐作为治疗癫痫的药物。
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