公开(公告)号：US20210283603A1

公开(公告)日：2021-09-16

申请号：US17198300

申请日：2021-03-11

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA

IPC: B01L3/00 ,  G01N35/08

Abstract: A liquid handling device includes a common channel, a plurality of wells, a magnetic beads chamber and a plurality of valves. The plurality of valves are rotary membrane valves disposed on the circumference of a first circle. The magnetic beads chamber is disposed on a circumference of the second circle concentric with the first circle.

公开(公告)号：US20210086185A1

公开(公告)日：2021-03-25

申请号：US16971407

申请日：2019-02-18

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA ,  Takumi YAMAUCHI

IPC: B01L3/00

Abstract: A first fluid handling device according to the present invention has: a first liquid introduction part; a first cleaning liquid introduction part; a first flow path through which a liquid introduced to the first liquid introduction part or to the first cleaning liquid introduction part flows; a second liquid introduction part; a second cleaning liquid introduction part; a second flow path through which a liquid introduced to the second liquid introduction part or to the second cleaning liquid introduction part flows; a third flow path which allows flowing therethrough of the liquid having flowed through the first flow path and the liquid having flowed through the second flow path; a first diaphragm valve that is disposed between the first and third flow paths; a second diaphragm valve that is disposed between the second and third flow paths; and a chamber that is connected to the third flow path.

公开(公告)号：US20170326547A1

公开(公告)日：2017-11-16

申请号：US15533764

申请日：2015-10-29

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA ,  Koji MURAKI

IPC: B01L3/00 ,  B01J19/00 ,  B81C1/00 ,  B29L31/00 ,  B29C65/02 ,  B29C65/00

CPC classification number: B01L3/502707 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00894 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B29C65/02 ,  B29C65/16 ,  B29C65/18 ,  B29C65/48 ,  B29C65/4895 ,  B29C66/028 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/53461 ,  B29C66/54 ,  B29C66/73118 ,  B29C66/73921 ,  B29L2031/756 ,  B32B37/02 ,  B32B37/04 ,  B81B3/00 ,  B81C1/00071 ,  G01N35/08 ,  G01N37/00

Abstract: In the present invention, a fluid handling device has: a first substrate made of resin whereon a channel is formed in a first surface; a first film made of resin and joined to the first surface of the first substrate; a second film made of resin a first surface of which is joined to a second surface of the first substrate; and a second substrate made of resin and joined to a second surface of the second film. A recessed part overlapping the channel in a plane view is formed on the surface of the second substrate joined to the second film. The glass transition temperature Tg1s of the first substrate, the glass transition temperature Tg1f of the first film, the glass transition temperature Tg2s of the second substrate, and the glass transition temperature Tg2f of the second film satisfy Tg1s, Tg2s>Tg1f, Tg2f.

公开(公告)号：US20220371004A1

公开(公告)日：2022-11-24

申请号：US17744689

申请日：2022-05-15

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA ,  Seiichiro SUZUKI ,  Koichi ONO

IPC: B01L3/00 ,  F16K7/17

Abstract: The present invention aims to provide a fluid handling device which can be manufactured more conveniently, can easily open and close a channel, and can be miniaturized. The fluid handling device of the present invention includes: a first channel; a second channel; and a valve disposed between the first channel and the second channel, in which the valve includes: a groove-shaped valve seat disposed in a board, and a flat plate-shaped flexible layer covering the groove-shaped valve seat, and the valve communicates between the first channel and the second channel when the flat plate-shaped flexible layer and a bottom of the groove-shaped valve seat are spaced apart from each other, and blocks communication between the first channel and the second channel when the flat plate-shaped flexible layer and an inner wall of the groove-shaped valve seat are in contact with each other.

公开(公告)号：US20220097053A1

公开(公告)日：2022-03-31

申请号：US17481606

申请日：2021-09-22

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA

IPC: B01L3/00

Abstract: A fluid handling device according to an embodiment of the present invention is a fluid handling device that includes a substrate and a film bonded to the substrate and that is configured to process a fluid, the fluid handling device including: a channel; a well connected to the channel; a rotary membrane valve disposed between the channel and the well; and a rotary membrane pump connected to the channel. For example, in the fluid handling device according to the embodiment of the present invention, a filter is disposed in the well or between the well and the rotary membrane valve for separating a blood cell component.

公开(公告)号：US20210252511A1

公开(公告)日：2021-08-19

申请号：US17259217

申请日：2019-06-17

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA

IPC: B01L3/00 ,  F16K11/22

Abstract: This fluid-handling device has: a first rotary member having a first protrusion that expands a diaphragm of a valve and closes off the valve, the first rotary member being capable of rotating about a rotational axis; a second rotary member disposed so as to surround the first rotary member, the second rotary member having a second protrusion that expands the diaphragm of the valve and closes off the valve, and being capable of rotating about the rotational axis independently from the first rotary member; and a plurality of rolling elements disposed between the first rotary member and the second rotary member, the plurality of rolling elements being in contact with the first rotary member and the second rotary member.

公开(公告)号：US20210008545A1

公开(公告)日：2021-01-14

申请号：US16976769

申请日：2019-02-25

Applicant: Enplas Corporation

Inventor： Yuya OSHIMA ,  Nobuya SUNAGA

IPC: B01L3/02 ,  B81B1/00 ,  G01N35/08

Abstract: This liquid handling device includes: a first flow passage through which a first liquid can flow; a second flow passage through which a second liquid can move; a third flow passage through which the second liquid can move; and a droplet generating unit, which is a merging portion of the second flow passage and the third flow passage with respect to the first flow passage, and which is configured in such a way that the first liquid flowing through the first flow passage is divided in the form of droplets by means of the second liquid flowing through the second flow passage and the third flow passage.

公开(公告)号：US20230158486A1

公开(公告)日：2023-05-25

申请号：US17959346

申请日：2022-10-04

Applicant: Enplas Corporation

Inventor： Yasuhiro WATANABE ,  Nobuya SUNAGA ,  Koichi ONO

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0084 ,  B01L2200/027 ,  B01L2400/0622 ,  B01L2400/0638 ,  B01L2400/0481

Abstract: A fluid handling device includes: a channel chip including a well for containing a fluid, a channel connected to the well, a valve disposed on the channel, and a through hole; and a pressing member including a first protrusion and a second protrusion, the first protrusion being for pressing the valve to close the valve, the second protrusion being inserted into the through hole and being for positioning the first protrusion with respect to the valve, the pressing member being rotatable about a rotational axis extending through the second protrusion.

公开(公告)号：US20230128269A1

公开(公告)日：2023-04-27

申请号：US17966974

申请日：2022-10-17

Applicant: Enplas Corporation

Inventor： Seiichiro SUZUKI ,  Nobuya SUNAGA

IPC: E02B8/04 ,  F16K27/04

Abstract: An object is to provide a fluid handling device which can be easily manufactured and which makes it possible for a valve to be easily opened and closed with a small force. A fluid handling device for achieving the above object includes a first region; a second region; and a valve disposed between the first region and the second region, in which the valve includes: a groove-shaped valve seat disposed in a board, and a flexible layer covering the groove-shaped valve seat, and a surface of the flexible layer facing the groove-shaped valve seat is a flat surface, a protrusion is disposed on a side of the flexible layer opposite to the groove-shaped valve seat and at a position corresponding to the groove-shaped valve seat.

公开(公告)号：US20210370302A1

公开(公告)日：2021-12-02

申请号：US16957758

申请日：2018-12-14

Applicant: Enplas Corporation

Inventor： Nobuya SUNAGA

IPC: B01L3/00

Abstract: The purpose of the present invention is to provide a liquid handling method that makes it possible to simply isolate a droplet, a fluid handling device used in this method, and a fluid handling system. This fluid handling method serves to flow a fluid including a solvent and a droplet through a fluid handling device comprising an inlet, a first flow path having one end connected to the inlet, a chamber connected to the other end of the first flow path, a second flow path having one end connected to the chamber, and an outlet connected to the other end of the second flow path. This fluid handling method includes an introduction step for introducing the fluid through the inlet and accommodating the droplet in the chamber, a rotation step for rotating the fluid handling device after the introduction step, and a removal step for removing the droplet from the inside of the chamber after the rotation step. In the introduction step, the fluid handling device is disposed such that the chamber widens from the position where the chamber and the second flow path are connected in the direction opposite from the direction of gravity.