公开(公告)号：US20240110136A1

公开(公告)日：2024-04-04

申请号：US18264691

申请日：2021-02-12

Applicant: ENPLAS CORPORATION

Inventor： Koichi ONO ,  Yasuhiro WATANABE

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06 ,  C12N5/071

CPC classification number: C12M21/08 ,  C12M23/16 ,  C12M25/04 ,  C12M29/10 ,  C12N5/0691 ,  C12N5/0697

Abstract: An object is to provide a novel organ-on-a-chip for forming a blood vessel model. An organ-on-a-chip 100 of the present invention is a chip for reproducing a biological process between a cell mass and a blood vessel. The organ-on-a-chip 100 includes a first channel 10, a second channel 20, and a third channel group. The first channel 10 is an introduction channel for introducing vascular endothelial cells for forming a blood vessel model on the inner wall of the first channel 10 through cell culture. The second channel 20 is an introduction channel for introducing a sample containing a cell mass from an upstream side toward a downstream side, and includes a trap portion 22 for trapping the cell mass and located between the upstream side and the downstream side inside the second channel 20. The third channel group includes a plurality of third channels 30, and the third channels 30 are channels that communicate between the first channel 10 and the second channel 20.

公开(公告)号：US20240091763A1

公开(公告)日：2024-03-21

申请号：US18283183

申请日：2021-03-25

Applicant: Enplas Corporation

Inventor： Koichi ONO ,  Yasuhiro WATANABE

IPC: B01L3/00

CPC classification number: B01L3/5027 ,  B01L2200/027

Abstract: The present invention pertains to a liquid handling device that comprises a laminate of a first member and a second member. This liquid handling device is provided with a reservoir that is a space for pooling a liquid and disposed between the first and second members, and a plurality of wells that are plurality of first recesses disposed on the surface of the first member facing the second member. The first and/or second members have flexibility. The first and second members are not bonded between the reservoir and the plurality of wells. When a part of the first or second member, said part corresponding to the reservoir, is pressed in the state where a liquid is pooled in the reservoir, the liquid in the reservoir moves between the first and second members toward the plurality of wells.

公开(公告)号：US20220241770A1

公开(公告)日：2022-08-04

申请号：US17588386

申请日：2022-01-31

Applicant: Enplas Corporation

Inventor： Hayato INOUE ,  Koichi ONO ,  Tomoki NAKAO ,  Shota TAKAMATSU ,  Yasuhiro WATANABE

IPC: B01L3/00 ,  G01N21/64 ,  B01L9/00

Abstract: A fluid handling device includes a board that includes a board body, and a lid that faces the first surface of the board and is disposed so as to form a space between the board and the lid. The lid includes a lid body including a second surface, and a first through hole which allows for injection of a fluid into the space and includes a first opening that opens onto the second surface and a second opening that opens onto a surface other than the second surface. The lid further includes a spacer which is integrally molded with the lid body; alternatively, the board includes a spacer which is integrally molded with the board body.

公开(公告)号：US20230158486A1

公开(公告)日：2023-05-25

申请号：US17959346

申请日：2022-10-04

Applicant: Enplas Corporation

Inventor： Yasuhiro WATANABE ,  Nobuya SUNAGA ,  Koichi ONO

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0084 ,  B01L2200/027 ,  B01L2400/0622 ,  B01L2400/0638 ,  B01L2400/0481

Abstract: A fluid handling device includes: a channel chip including a well for containing a fluid, a channel connected to the well, a valve disposed on the channel, and a through hole; and a pressing member including a first protrusion and a second protrusion, the first protrusion being for pressing the valve to close the valve, the second protrusion being inserted into the through hole and being for positioning the first protrusion with respect to the valve, the pressing member being rotatable about a rotational axis extending through the second protrusion.

公开(公告)号：US20200316608A1

公开(公告)日：2020-10-08

申请号：US16758334

申请日：2018-11-26

Applicant: ENPLAS CORPORATION

Inventor： Nobuhiro KOJIMA ,  Yasuhiro WATANABE ,  Koji MURAKI ,  Tomoki NAKAO

IPC: B01L9/00 ,  B01L3/00

Abstract: A placement holder 1 for an analysis according to the present invention includes a frame portion 10 for placing an analysis plate, and a coupling portion 11; wherein the analysis plate includes, respectively at opposite ends in a longitudinal direction thereof, protrusions protruding in the longitudinal direction; the frame portion 10 includes a pair of wall portions that are opposed to each other, and a space surrounded by the frame portion 10 has an area 12 in which the analysis plate is to be placed; the pair of wall portions have a pair of cavities 13 into which the protrusions of the analysis plate are to be inserted, and at least one of the pair of cavities 13 is a through hole; the wall portion having the through hole has, on an inner surface thereof, an inclined surface 14 formed such that an interval between inner surfaces of the pair of wall portions gradually decreases from an upper end side toward the through hole of the wall portion; and the coupling portion 11 is disposed below the pair of cavities 13 so as to couple one of the wall portions to the other wall portion.